MECHANISM OF PROTECTIVE IMMUNITY INDUCED BY EBOLA VACCINES

埃博拉疫苗诱导保护性免疫的机制

• 批准号: 8172781
• 负责人: DAVID M ANDERSON
• 金额: $ 15.51万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172781
• 关键词: Antibody Formation; CD8B1 gene; Computer Retrieval of Information on Scientific Projects Database; Ebola Hemorrhagic Fever; Ebola Vaccines; Funding; Goals; Grant; Immunity; Institution; Macaca fascicularis; Measures; Modeling; Research; Research Personnel; Resources; Role; Source; T cell response; T-Lymphocyte; United States National Institutes of Health; Vaccines; Viral Antibodies; Antibody Formation; CD8B1 gene; Computer Retrieval of Information on Scientific Projects Database; Ebola Hemorrhagic Fever; Ebola Vaccines; Funding; Goals; Grant; Immunity; Institution; Macaca fascicularis; Measures; Modeling; Research; Research Personnel; Resources; Role; Source; T cell response; T-Lymphocyte; United States National Institutes of Health; Vaccines; Viral Antibodies

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to interrogate the determinants of immunity in the NHP model of Ebola hemorrhagic fever, by measuring the contribution of antiviral antibody and T cell responses conferred by VSV-ZEBOVgp. This will be accomplished by uncovering the role of CD8 T cell versus antibody response elicited by this vaccine in Cynomolgus monkeys.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是通过测量VSV-ZEBOVGP赋予的抗病毒抗体和T细胞反应的贡献来审问埃博拉出血热NHP模型中免疫的决定因素。这将通过发现该疫苗在cynomolgus猴子中引起的CD8 T细胞与抗体反应的作用来实现。