MECHANISM OF PROTECTIVE IMMUNITY INDUCED BY EBOLA VACCINES

埃博拉疫苗诱导保护性免疫的机制

• 批准号: 8357611
• 负责人: DAVID M ANDERSON
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357611
• 关键词: Antibody Formation; CD8B1 gene; Ebola Hemorrhagic Fever; Ebola Vaccines; Funding; Goals; Grant; Immunity; Measures; Modeling; National Center for Research Resources; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Source; T cell response; T-Lymphocyte; United States National Institutes of Health; Vaccines; Vesicular stomatitis Indiana virus; Viral Antibodies; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this study is to interrogate the determinants of immunity in the NHP model of Ebola hemorrhagic fever, by measuring the contribution of antiviral antibody and T cell responses conferred by VSV-ZEBOVgp. This will be accomplished by uncovering the role of CD8 T cell versus antibody response elicited by this vaccine in m. fascicularis.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 这项研究的目的是通过测量VSV-ZEBOVGP赋予的抗病毒抗体和T细胞反应的贡献来审问埃博拉出血热NHP模型中免疫的决定因素。这将通过发现该疫苗在M中引起的CD8 T细胞与抗体反应的作用来实现。筋膜。