CLINICAL RAMAN INSTRUMENT

临床拉曼仪器

• 批准号: 8170405
• 负责人: ZOYA VOLYNSKAYA
• 金额: $ 1.9万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170405
• 关键词: Atherosclerosis; Biological; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Diagnostic Procedure; Fingerprint; Fostering; Funding; Grant; Institution; Laboratories; Microscopy; Optics; Raman Spectrum Analysis; Research; Research Personnel; Resources; Source; Spectrum Analysis; System; Tissues; Translational Research; United States National Institutes of Health; base; in vivo; instrument; malignant breast neoplasm; optical fiber

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have investigated the usage of Raman spectroscopy to diagnose atherosclerosis and breast cancer. Over the years, we have successfully conducted several in vivo and ex vivo clinical studies. We were able to minimize our microscopy-based laboratory system into a clinical Raman system utilizing a Raman fiber optical probe. Currently, we are developing a mini-Raman clinical instrument that will be available for users outside of the LBRC. The purposes of this project are to foster clinical translational research in optical spectroscopy; and to familiarize young/new investigators with the methods of diagnostic spectroscopy. The LBRC will provide Raman spectroscopy instrument capable of collecting Raman spectra from biological tissues over the fingerprint range (600-1800cm-1).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们研究了拉曼光谱在诊断动脉粥样硬化和乳腺癌中的用途。多年来，我们已成功进行了多项体内和离体临床研究。我们能够将基于显微镜的实验室系统最小化为利用拉曼光纤探头的临床拉曼系统。目前，我们正在开发一种迷你拉曼临床仪器，可供 LBRC 以外的用户使用。该项目的目的是促进光谱学的临床转化研究；并使年轻/新研究人员熟悉诊断光谱学方法。 LBRC将提供拉曼光谱仪器，能够收集指纹范围（600-1800cm-1）内生物组织的拉曼光谱。