EX VIVO MULTIMODAL SPECTROSCOPY OF BREAST CANCER

乳腺癌的体外多模态光谱学

• 批准号: 8170393
• 负责人: ZOYA VOLYNSKAYA
• 金额: $ 2.85万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170393
• 关键词: Clinical; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Diffuse; Excision; Fibroadenoma; Fluorescence Spectroscopy; Funding; Grant; Hour; Institution; Lesion; Mammary Gland Parenchyma; Mastectomy; Medical center; Modality; Pathology; Research; Research Personnel; Resources; Sensitivity and Specificity; Site; Source; Spectrum Analysis; United States National Institutes of Health; University Hospitals; infiltrating duct carcinoma; instrument; malignant breast neoplasm

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have developed the MMS instrument that combines Raman, diffuse reflectance and intrinsic fluorescence spectroscopy modalities. Our previous results obtained from two clinical instruments that provide information on Raman and combination of diffuse reflectance and intrinsic fluorescence spectroscopies, respectively, have allowed us to diagnose normal, fibrocystic change, fibroadenoma and infiltrating ductal carcinoma lesions with high sensitivity and specificity. In the new clinical ex vivo study spectral information from all three modalities will be collected from the same site of the freshly excised breast tissue via multimodal front-viewing probe. This study will be conducted in the pathology suite in the University Hospitals-Case medical center within half an hour of excision during partial and whole mastectomy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们开发了结合拉曼、漫反射和本征荧光光谱模式的 MMS 仪器。我们之前从两台临床仪器获得的结果分别提供拉曼信息以及漫反射和固有荧光光谱的组合，使我们能够以高灵敏度和特异性诊断正常、纤维囊性变、纤维腺瘤和浸润性导管癌病变。在新的临床离体研究中，将通过多模态前视探头从新鲜切除的乳腺组织的同一部位收集所有三种模式的光谱信息。这项研究将在部分和整个乳房切除术期间在切除后半小时内在大学医院凯斯医疗中心的病理室进行。