MULTIMODAL SPECTROSCOPY PROBE DEVELOPMENT

多模态光谱探头开发

• 批准号: 8170381
• 负责人: ZOYA VOLYNSKAYA
• 金额: $ 1.9万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170381
• 关键词: Atherosclerosis; Clinical; Collection; Computer Retrieval of Information on Scientific Projects Database; Coupling; Development; Diffuse; Fiber; Fluorescence; Funding; Grant; Institution; Light; Modality; Optics; Raman Spectrum Analysis; Research; Research Personnel; Resources; Signal Transduction; Site; Source; Spectrum Analysis; Tissues; United States National Institutes of Health; breast cancer diagnosis; design; instrument

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have developed a spectral probe that combines three spectroscopic modalities of diffuse reflectance, fluorescence and Raman spectroscopy to diagnose breast cancer and atherosclerosis. The combined probe provides capability of collecting the three spectroscopic modalities from the same tissue site, by delivering and collecting light in the 300-1000 nm spectral range. The probe also allows coupling of multiple sources into its single excitation fiber, while utilizing excitation and emission filters with specially designed optical coatings to suppress fiber background in the collected signal. Collection fibers is split up and redirected to two spectrograph/CCD modules of the clinical instrument for spectral analysis and parameter extraction.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们开发了一种光谱探针，结合了漫反射、荧光和拉曼光谱三种光谱模式来诊断乳腺癌和动脉粥样硬化。组合探头通过传输和收集 300-1000 nm 光谱范围内的光，提供从同一组织部位收集三种光谱模式的能力。该探头还允许将多个源耦合到其单个激发光纤中，同时利用带有专门设计的光学涂层的激发和发射滤波器来抑制所收集信号中的光纤背景。收集光纤被分开并重定向到临床仪器的两个光谱仪/CCD 模块，用于光谱分析和参数提取。