CORTICAL DIFFERENCES IN PATIENTS WITH ANTISOCIAL PERSONALITY DISORDER

反社会人格障碍患者的皮质差异

• 批准号: 8171104
• 负责人: MARINA BOCCARDI
• 金额: $ 0.61万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171104
• 关键词: Affect; Antisocial Personality Disorder; Bilateral; Brain; Computer Retrieval of Information on Scientific Projects Database; Functional disorder; Funding; Grant; Individual; Institution; Investigation; Lateral; Left; Magnetic Resonance Imaging; Medial; Methods; Patients; Pattern; Prefrontal Cortex; Research; Research Personnel; Resources; Sensory; Source; United States National Institutes of Health; association cortex; cerebral atrophy; gray matter; male; men; neuroimaging; psychopathic personality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Few neuroimaging studies have focused on antisocial personality disorder, however recent investigations suggest cortical thinning in the medial prefrontal cortex and lateral sensory and surrounding association cortices, as well as decreased volume in the prefrontal cortex and total brain. Methods: We aimed to identify anatomical patterns of cortical atrophy in 26 antisocial personality disorder males compared to 25 male healthy controls using magnetic resonance imaging volumetry and cortical pattern matching. Results: Antisocial personality disorder individuals as compared to healthy controls showed gray matter loss affecting bilateral medial prefrontal, orbitofrontal, cingulate and occipital, and left somatosensori cortices. Right occipital, left cingulate, and ventral orbitofrontal cortices loss were further pronounced in antisocial personality disorder individuals with high psychopathy respect to healthy controls than antisocial personality disorder individuals with low psychopathy compared to healthy controls. Conclusion: Men with antisocial personality disorder present cortical loss in orbitofrontal, medial prefrontal, cingulate and occipital regions compared to healthy individuals. Structural abnormalities on these regions may be implicated in the pathophysiology of antisocial personality disorder.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 背景：很少有神经影像学研究集中在反社会人格障碍上，但是最近的研究表明，内侧前额叶皮层和横向感觉和周围缔合皮层的皮质稀疏，以及前额叶皮质和总脑的体积减少。 方法：我们旨在确定26种反社会人格障碍男性皮质萎缩的解剖模式，而使用磁共振成像体积和皮质图案匹配的25种男性健康对照组，而男性健康对照组。 结果：与健康对照组相比，反社会人格障碍个体显示出灰质损失，影响双侧内侧前额叶，轨道额，扣带和枕骨，并剩下Somatosensori Cortices。右枕骨，左扣带回和腹侧眶额皮质的损失在反社会人格障碍的个体中与健康对照低的反社会人格障碍个体相比，与健康对照相比，对健康对照的尊重高于精神病患者。 结论：与健康个体相比，患有反社会人格障碍的男性表现出皮质损失。这些区域的结构异常可能与反社会人格障碍的病理生理有关。