HIPPO MORPHOMETRY IN FRONTOTEMPORAL DEMENTIA: A RADIAL ATROPHY MAPPING STUDY

额颞叶痴呆中的河马形态测量：桡骨萎缩图谱研究

• 批准号: 8363439
• 负责人: MARINA BOCCARDI
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363439
• 关键词: Alzheimer' s Disease; Atrophic; Computer software; Dementia; Detection; Frontotemporal Dementia; Funding; Grant; Head; Hippocampal Formation; Hippocampus (Brain); Image; Individual; Location; Magnetic Resonance Imaging; Manuals; Maps; Measures; Medial; Methods; Modeling; Morphology; National Center for Research Resources; Patients; Principal Investigator; Protocols documentation; Psychiatry; Radial; Radiology Specialty; Research; Research Infrastructure; Resources; Slice; Source; Spatial Distribution; Surface; Techniques; Time; United States National Institutes of Health; Universities; base; computational anatomy; cost; entorhinal cortex; hippocampal atrophy; in vivo; indexing; millisecond; morphometry; neuroimaging; neuropathology; Alzheimer' s Disease; Atrophic; Computer software; Dementia; Detection; Frontotemporal Dementia; Funding; Grant; Head; Hippocampal Formation; Hippocampus (Brain); Image; Individual; Location; Magnetic Resonance Imaging; Manuals; Maps; Measures; Medial; Methods; Modeling; Morphology; National Center for Research Resources; Patients; Principal Investigator; Protocols documentation; Psychiatry; Radial; Radiology Specialty; Research; Research Infrastructure; Resources; Slice; Source; Spatial Distribution; Surface; Techniques; Time; United States National Institutes of Health; Universities; base; computational anatomy; cost; entorhinal cortex; hippocampal atrophy; in vivo; indexing; millisecond; morphometry; neuroimaging; neuropathology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. 'Background: similar amount of hippocampal atrophy has been repeatedly detected in studies comparing FTD to AD patients, nonetheless the distribution of the atrophic changes may be different. Recent techniques such as radial atrophy mapping allow to characterize the atrophic changes of different kinds of dementia based not only on the absolute quantity of atrophy, but also on its spatial distribution. Methods: MRI images from 9 FTD patients and 27 controls were collected at the Radiology Department, University of Verona with a 1.5 Tesla unit (Siemens, Magnetom) and a standard head coil. A gradient-echo 3D-technique was employed for image acquisition with: TR 10 msec; TE 4 msec; TI 300 msec; flip angle 10?; field of view 250 mm; acquisition 2; matrix 160?256. Total acquisition time was 7:40 minutes. MRI images will be normalized by linear (12 parameter) transformation to a customized template using the Statistical Parametric Mapping (SPM99) software. The hippocampi will be manually traced according to a formal protocol with established inter- and intra-rater reliability and 3D parametric surface mesh models will be created to represent the hippocampus in each subject. In order to assess hippocampal morphology, a medial curve will be automatically defined as the 3D curve traced out by the centroid of the hippocampal boundary in each image slice. The radial size of each hippocampus at each boundary point will be assessed by automatically measuring the radial 3D distance from the surface points to the medial curve defined for individual's hippocampal surface model. Shorter radial distances will be used as an index of atrophy. Statistical maps will be generated indicating local group differences in radial hippocampal distance. Expected results: the experimental prediction consists in the detection of atrophy in the anteriormost sectors of the hippocampus, as already suggested by a study based on manual tracings (Laakso et al., 2000) or anyway in a different location from that of AD, that involves the CA1 sector and part of the subiculum. Laakso MP, Frisoni GB, Kononen M, Mikkonen M, Beltramello A, Geroldi C, Bianchetti A, Trabucchi M, Soininen H, Aronen HJ. Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: a morphometric MRI study. Biol Psychiatry. 2000;47:1056-63. Frisoni GB, Sabattoli F, Lee AD, Dutton RA, Toga AW, Thompson PM. In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study. Neuroimage. 2006; 32(1):104-10.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 '背景：在将FTD与AD患者进行比较的研究中，已经反复检测到类似数量的海马萎缩，尽管如此，萎缩变化的分布可能不同。诸如径向萎缩图之类的最新技术允许表征不同种类的痴呆症的萎缩变化，这不仅基于萎缩的绝对量，而且基于其空间分布。 方法：来自维罗纳大学放射学系的9名FTD患者和27个对照的MRI图像，其1.5特斯拉单元（Siemens，Magnetom）和标准头部线圈。使用：TR 10毫秒，采用了梯度回波3D技术进行图像采集； TE 4毫秒； Ti 300毫秒;翻盖角度10？视野250毫米；收购2；矩阵160？256。总收购时间为7:40分钟。 MRI图像将通过使用统计参数映射（SPM99）软件进行线性（12个参数）转换为自定义模板进行标准化。海马将根据具有建立的评估者间可靠性的形式协议手动追踪，并将创建3D参数表面网格模型以表示每个受试者的海马。为了评估海马形态，每个图像切片中海马边界的质心自动将内侧曲线自动定义为3D曲线。每个边界点的每个海马的径向大小将通过自动测量从表面点到定义为个人海马表面模型定义的内侧曲线的径向3D距离来评估。较短的径向距离将用作萎缩的指数。将生成统计图，表明径向海马距离的局部组差异。 预期结果：实验预测包括在海马的前骨菌群中检测萎缩，正如一项基于手动示踪的研究所建议的那样（Laakso等，2000）或与AD不同的位置，涉及CA1扇区和一部分。 Laakso MP，Frisoni GB，Kononen M，Mikkonen M，Beltramello A，Geroldi C，Bianchetti A，Trabucchi M，Soininen H，Aronen HJ。 额颞痴呆和阿尔茨海默氏病的海马和内嗅皮层：形态计量学MRI研究。生物精神病学。 2000; 47：1056-63。 Frisoni GB，Sabattoli F，Lee AD，Dutton RA，Toga AW，Thompson PM。 AD中海马形成的体内神经病理学：基于径向映射的基于MR的研究。神经图像。 2006; 32（1）：104-10。