Clinical Core

临床核心

• 批准号: 7930106
• 负责人: John A Bartlett
• 金额: $ 27.38万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7930106
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Area; Automobile Driving; Back; Clinical; Clinical Investigator; Clinical Research; Collaborations; Communities; Databases; Development; Environment; Faculty; Funding; Good Clinical Practice; HIV; Human Subject Research; Institutes; Interdisciplinary Study; International; Laboratories; Laboratory Scientists; Link; Malignant Neoplasms; Mission; Pathogenesis; Patients; Recruitment Activity; Research; Research Personnel; Services; Site; Specimen; Translating; Universities; bench to bedside; global health; investigator-initiated translational research; novel; patient oriented research; repository; symposium

Core F The Duke University CFAR Clinical Core (Core F) provides a dynamic, higlily motivated and effective environment for HIV-related clinical studies within the Duke CFAR. In line with the overall mission for a CFAR, this Core provides "value-added" to facilitate patient-oriented research by providing clinical research expertise, regulatory support, access to patient specimens, and community involvement. The Core is responsive to the needs of the investigators within Duke and has aggressively pursued opportunities to expand clinical opportunities in Durham and through international sites. This Core has three specific aims: 1) To facilitate cutting edge patient-oriented research by clinical and laboratory investigators through the development of new Core services responsive to investigator needs and CFAR priorities such as international collaborations, and an enhanced database linked to a specimen repository; 2) To catalyze patient-oriented research collaborations between Duke CFAR investigators, especially within CFAR priority areas of HIV pathogenesis and AIDS-associated malignancies, by translating the hypotheses of Duke CFAR investigators into clinical studies, bringing novel clinical observations back to laboratory investigators, facilitating and leading interdisciplinary research teams, and actively participating in CFAR conferences and symposia; 3) To attract new investigators into patient-oriented research investigating HIV/AIDS by emphasizing interdisciplinary research efforts, communicating with key partners such as the Duke Global Health Institute and the Duke Comprehensive Cancer Institute, suggesting new collaborations, and recruiting new Duke faculty. Clinical Core accomplishments from the first four years suggest that the Clinical Core will thrive as the centerpiece of patient-oriented research within the CFAR in the next funding cycle, driving the CFAR to realize its scientific priorities.

核心F 杜克大学 CFAR 临床核心（Core F）为杜克大学 CFAR 内的 HIV 相关临床研究提供了一个充满活力、积极主动且有效的环境。根据 CFAR 的总体使命，该核心通过提供临床研究专业知识、监管支持、获取患者标本和社区参与来提供“增值”，以促进以患者为导向的研究。核心响应杜克大学内部调查人员的需求，并积极寻求机会 扩大达勒姆和国际站点的临床机会。该核心有三个具体目标： 1) 通过开发新的核心服务来响应研究者的需求和 CFAR 优先事项（例如国际合作）以及链接到样本存储库的增强数据库，促进临床和实验室研究者进行尖端的以患者为导向的研究; 2) 通过将杜克大学 CFAR 研究人员的假设转化为临床研究，将新的临床观察结果带回给实验室研究人员，促进杜克大学 CFAR 研究人员之间以患者为导向的研究合作，特别是在 HIV 发病机制和艾滋病相关恶性肿瘤的 CFAR 优先领域内。领导跨学科研究团队，积极参加CFAR会议和研讨会； 3) 通过强调跨学科研究工作、与杜克大学全球健康研究所和杜克综合癌症研究所等主要合作伙伴进行沟通、建议新的合作以及招募新的杜克大学教师，吸引新的研究人员参与以患者为导向的艾滋病毒/艾滋病研究。前四年的临床核心成就表明，临床核心将在下一个资助周期中作为 CFAR 内以患者为导向的研究的核心而蓬勃发展，推动 CFAR 实现其科学优先事项。