USE OF PHONOCARDIOGRAM IN SCREENING NEONATES FOR CONGENITAL HEART DISEASE

使用心音图筛查新生儿先天性心脏病

• 批准号: 8174491
• 负责人: RUEY-KANG R CHANG
• 金额: $ 1.87万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174491
• 关键词: Accounting; Birth; Cessation of life; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Congenital Abnormality; Diagnosis; Electrocardiogram; Event; Feasibility Studies; Foundations; Funding; Future; Grant; Heart Sounds; Hospitals; Infant; Institution; Life; Morbidity - disease rate; Newborn Infant; Pulse Oximetry; Research; Research Personnel; Resources; Screening procedure; Source; Techniques; Technology; Testing; United States National Institutes of Health; congenital heart disorder; disease diagnosis; neonate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Congenital heart disease (CHD) is the most common major congenital anomaly and account for the majority of death due to congenital malformation in the first year of life. Many infants born with CHD are discharged from hospital after birth without being diagnosed. Delayed diagnosis and treatment can often result in life-threatenting events and significant morbidities in these infants. Therefore, early CHD diagnosis using screening techniques may be life-saving. Previous researchers have used ECG and pulse oximetry as screening for CHD with some promises. We propose to use heart sound in addition to current technology to aid CHD screening in newborns. The achieve this, we propose the current feasibility study on newborn heart sounds to establish the foundation for our future studies on CHD screening in newborns. This study has two specific aims: Specific Aim#1 To test the feasibility of heart sound recording in newborns Specific Aim#2 To determine the heart sound characteristics and parameters in newborns

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 先天性心脏病（CHD）是最常见的主要先天性异常，占出生后第一年因先天性畸形导致的死亡的大部分。 许多患有先天性心脏病的婴儿出生后未经诊断就出院了。 延迟诊断和治疗通常会导致这些婴儿出现危及生命的事件和严重的发病率。 因此，使用筛查技术进行早期冠心病诊断可能会挽救生命。 之前的研究人员已经使用心电图和脉搏血氧测定法来筛查冠心病，并取得了一些希望。 我们建议在现有技术的基础上使用心音来帮助新生儿进行先心病筛查。 为了实现这一目标，我们提出目前对新生儿心音的可行性研究，为我们未来的新生儿冠心病筛查研究奠定基础。 这项研究有两个具体目标： 具体目标#1 测试新生儿心音记录的可行性 具体目标#2 确定新生儿的心音特征和参数