USE OF PHONOCARDIOGRAM IN SCREENING NEONATES FOR CONGENITAL HEART DISEASE

使用心音图筛查新生儿先天性心脏病

• 批准号: 8174491
• 负责人: RUEY-KANG R CHANG
• 金额: $ 1.87万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174491
• 关键词: Accounting; Birth; Cessation of life; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Congenital Abnormality; Diagnosis; Electrocardiogram; Event; Feasibility Studies; Foundations; Funding; Future; Grant; Heart Sounds; Hospitals; Infant; Institution; Life; Morbidity - disease rate; Newborn Infant; Pulse Oximetry; Research; Research Personnel; Resources; Screening procedure; Source; Techniques; Technology; Testing; United States National Institutes of Health; congenital heart disorder; disease diagnosis; neonate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Congenital heart disease (CHD) is the most common major congenital anomaly and account for the majority of death due to congenital malformation in the first year of life. Many infants born with CHD are discharged from hospital after birth without being diagnosed. Delayed diagnosis and treatment can often result in life-threatenting events and significant morbidities in these infants. Therefore, early CHD diagnosis using screening techniques may be life-saving. Previous researchers have used ECG and pulse oximetry as screening for CHD with some promises. We propose to use heart sound in addition to current technology to aid CHD screening in newborns. The achieve this, we propose the current feasibility study on newborn heart sounds to establish the foundation for our future studies on CHD screening in newborns. This study has two specific aims: Specific Aim#1 To test the feasibility of heart sound recording in newborns Specific Aim#2 To determine the heart sound characteristics and parameters in newborns

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 先天性心脏病（CHD）是最常见的主要先天性异常，原因是由于先天性畸形在生命的第一年而导致的大部分死亡。 出生后出生后出生的许多患有冠心病的婴儿在没有被诊断的情况下出院。 延迟的诊断和治疗通常会导致威胁生命的事件和这些婴儿的大量病毒。 因此，使用筛查技术的早期冠心病诊断可能会挽救生命。 以前的研究人员已使用ECG和脉搏血氧饱和度来筛查CHD，并有一些承诺。 我们建议除了当前的技术外，还建议使用心脏声音来帮助新生儿中的CHD筛查。 实现这一目标，我们提出了当前关于新生儿心脏声音的可行性研究，为我们对新生儿冠心病筛查的未来研究奠定了基础。 这项研究有两个具体的目标： 特定目标＃1测试新生儿心脏声音录音的可行性 特定的目标＃2确定新生儿的心脏声音特征和参数