Infant Sleep Environment Monitoring System (SEMS) for SIDS

针对 SIDS 的婴儿睡眠环境监测系统 (SEMS)

• 批准号: 8395020
• 负责人: RUEY-KANG R CHANG
• 金额: $ 28.14万
• 依托单位: INTELLIGENT OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8395020
• 关键词: Acoustics; Age-Months; Algorithms; American; Apnea; Area; Asphyxia; Back to Sleep; Beds; Biomedical Research; Body Temperature; California; Carbon Dioxide; Cause of Death; Clinical Research; Clinical Trials; Clothing; Collaborations; Complex; Computers; Data; Detection; Development; Devices; Electronics; Engineering; Environment; Environmental Risk Factor; Family; Future; Goals; Head; Heat Stress Disorders; Incidence; Infant; Internet; Lead; Legal patent; Link; Literature; Los Angeles; Measures; Medical; Medical center; Monitor; Optics; Pain; Parents; Performance; Phase; Polysomnography; Prevention Research; Process; Qualifying; Reaction Time; Research; Research Institute; Research Personnel; Respiratory Sounds; Risk; Risk Factors; Scientist; Secure; Signal Transduction; Skin; Sleep; Sudden infant death syndrome; System; Telemetry; Temperature; Testing; Universities; Validation; Wireless Technology; base; clinically relevant; clinically significant; computerized data processing; design; effective intervention; environmental change; high risk infant; human subject; meetings; miniaturize; modifiable risk; notch protein; optical sensor; phase 1 study; phase 2 study; prevent; product development; research clinical testing; respiratory; sensor; sleep position; success

DESCRIPTION (provided by applicant): Many cases of Sudden Infant Death Syndrome (SIDS) could be avoided if the known sleep situations linked to SIDS could be detected and corrected way early before suffocation and/or apnea occurs. Prone sleep position and covering of the head by bedding are two most important environmental risk factors for SIDS. The infant Sleep Environment Monitoring System (SEMS) is designed to detect these conditions that lead to changes in key parameters signaling the onset of the complex pathophysiologic processes for SIDS. The SEMS is a wireless local and remote monitoring system that consists of three components: an Infant Module (IM), a Local Gateway, and a Remote Monitoring Server. The IM transmits signals wirelessly to a local gateway device by the crib, which processes the signals and sends results via the Internet to a secure remote monitoring server. The IM will be attached to the baby's clothing with a small area of skin contact at the suprasternal notch. Four sensors will be placed in the IM to monitor important sleep environmental changes which are early precursors for SIDS. The SEMS sensor package includes accelerometers for sleep position, an optical CO2 microsensor, a thermistor for temperature, and an acoustic sensor for airway flow. Sleep position - Avoiding prone sleep position is the most important way to prevent SIDS. Carbon dioxide and Temperature - In clinically significant head-covering episodes, CO2 accumulates and body temperature rises, leading to CO2 rebreathing, heat stress and ultimately respiratory suppression and apnea. Airway flow - A decreased of airway acoustic signals can be detected before suffocation and apnea occur. In the Phase I study we aim to develop and validate all 4 sensors used in the IM. The unique collaboration between Intelligent Optical Systems, the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, and the Electrical and Computer Engineering Department of the University of California Irvine formed to carry out this project is imminently qualified to take it from Phase I proof of principal through final product development and clinical testing. A patent application for this approach has been filed. PUBLIC HEALTH RELEVANCE: This project will develop an easy-to-use monitor to help prevent "crib death" (sudden infant death syndrome, or SIDS), which causes the painful loss of a baby in 2,500 American families each year. The infant Sleep Environment Monitoring System (SEMS), developed by a team of medical researchers, sensor scientists, and electronic engineers, will use a miniaturized sensor package to measure critical sleep parameters, including sleep position, carbon dioxide, temperature, and breathing sounds. The SEMS will focus on sleep position and head covering by bedding -- the two most important risk factors in an infant's sleep environment that can be recognized and corrected by parents to prevent SIDS.

描述（由申请人提供）：如果可以在窒息和/或呼吸暂停之前，可以检测到与SID相关的已知睡眠情况并纠正许多婴儿死亡综合征（SID）的许多病例。俯卧的睡眠位置和通过床上用品覆盖的头部覆盖是小巧的两个最重要的环境风险因素。婴儿睡眠环境监测系统（SEMS）旨在检测这些条件，从而导致关键参数的变化，该参数发出了SIDS的复杂病理生理过程的发作。 SEMS是一个无线本地和远程监视系统，由三个组件组成：婴儿模块（IM），本地网关和远程监视服务器。 IM将信号无线传输到CRIB的本地网关设备，该设备处理信号并通过Internet发送结果到安全的远程监视服务器。 IM将在婴儿脱口机上附有带有少量皮肤接触的婴儿衣服。 IM将放置四个传感器，以监视重要的睡眠环境变化，这是SIDS的早期前体。 SEMS传感器套件包括用于睡眠位置的加速度计，光学二氧化碳微传感器，温度热电阻和气道流量传感器。睡眠位置 - 避免易于睡眠的位置是预防小岛屿发展中心的最重要方法。二氧化碳和温度 - 在临床上明显的头部覆盖发作中，二氧化碳积累和体温升高，导致二氧化碳的重新呼吸，热应激以及最终导致呼吸道抑制和呼吸呼吸呼吸。气道流 - 在窒息和呼吸暂停之前，可以检测到气道声信号的减少。在I阶段研究中，我们旨在开发和验证IM中使用的所有4个传感器。智能光学系统，Harbour-UCLA医疗中心的洛杉矶生物医学研究所与加利福尼亚大学欧文分校的电气和计算机工程系之间的独特合作，旨在执行该项目的电气和计算机工程系有资格从I阶段的I阶段证明中获得。 通过最终产品开发和临床测试。已提交了此方法的专利申请。 公共卫生相关性：该项目将开发易于使用的监视器，以帮助防止“婴儿床死亡”（突然的婴儿死亡综合症或小岛屿发展中国家），这每年会导致2500个美国家庭中的婴儿痛苦。由医学研究人员，传感器科学家和电子工程师团队开发的婴儿睡眠环境监测系统（SEMS）将使用微型传感器包装来测量关键睡眠参数，包括睡眠位置，二氧化碳，温度和呼吸声。 SEMS将专注于睡眠位置和床上用品的头部覆盖 - 婴儿睡眠环境中最重要的危险因素可以被父母识别和纠正以防止小岛屿发展中心。