Magnetic Resonance Imaging-Guided Cancer Interventions

磁共振成像引导的癌症干预

基本信息

批准号：
8152749
负责人：
Kim Butts-Pauly
金额：
$ 166.73万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-22 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8152749
关键词：
Ablation Acoustics Adverse effects Algorithms Animals Area Basic Science Biopsy Brain Cadaver Cancer Center Cancer Control Cancer Intervention Cessation of life Clinical Clinical Trials Computer software Cryosurgery Development Devices Diagnostic Doctor of Medicine Doctor of Philosophy Doctor of Veterinary Medicine Effectiveness Electromagnetic Fields Engineering Evaluation Feedback Focused Ultrasound Therapy Foundations Funding Gold Histology Human Image Imagery In Vitro Individual Intervention Kidney Lesion Limb structure Liver Magnetic Resonance Imaging Malignant Neoplasms Malignant neoplasm of pancreas Maps Methods Monitor Neoplasms Operative Surgical Procedures Organ Outcome Pancreas Pathologic Patients Procedures Prostate Prostatic Diseases Prostatic Neoplasms Radiation Radiofrequency Interstitial Ablation Research Research Infrastructure Retroperitoneal Space Robotics Services Shapes Soft Tissue Neoplasms Structure Techniques Technology Temperature Testing Thermal Ablation Therapy Time Tissues Transducers Translations Ultrasonography United States National Institutes of Health Work calcification cancer therapy clinically significant density design effective therapy haptics human subject improved in vivo medical schools meetings minimally invasive new technology oncology programs response statistics tumor

项目摘要

This project aims to develop and test controlled minimally invasive thermal ablation techniques for the treatment of cancers that are attributed to a quarter of cancer deaths. We aim to provide precise imaging, feedback, and control of the shape and size of thermal lesions to improve the treatment options for these patients. Built upon the foundation of the Stanford Schools of Medicine and Engineering, the Stanford Cancer Center, and collaborators from UCSF and HeartVista, this program brings together five projects: 1) MR-guided HIFU of soft tissue tumors, 2) Minimally Invasive MRI-Guided Management of Prostate Disease, 3) MR-Guided Precision Thermal Therapy of Retroperitoneal Tumors, 4) MRI Methods for Guiding Focused Ultrasound in the Brain and 5) MR-guided RF Ablation. The five projects have many common requirements for programmatic and infrastructure support, which have been consolidated into cores. An engineering core will support Projects 2-5 with control hardware and software, as well as improved device visualization. An in vivo study support core will assist all of the projects with post ablation assessment imaging, correlation with histology, and statistical support. The outcomes of this PPG will be 1) improved minimally-invasive treatment options, 2) an increase in the basic science understanding of tissue response to thermal treatments, and 3) advances in engineering, both hardware and software, specifically for treatment of these cancers.

该项目旨在开发和测试受控微创热消融技术，用于治疗癌症，四分之一的癌症死亡归因于癌症。我们的目标是提供精确的成像、反馈以及热损伤形状和大小的控制，以改善这些患者的治疗选择。该项目以斯坦福大学医学与工程学院、斯坦福癌症中心以及 UCSF 和 HeartVista 的合作者为基础，汇集了五个项目：1) MR 引导的软组织肿瘤 HIFU，2) 微创 MRI 引导前列腺疾病的治疗，3) MR 引导的腹膜后肿瘤精准热疗，4) 引导脑部聚焦超声的 MRI 方法5) MR 引导的射频消融。这五个项目对计划和基础设施支持有许多共同要求，这些要求已合并为核心。工程核心将通过控制硬件和软件以及改进的设备可视化来支持项目 2-5。体内研究支持核心将通过消融后评估成像、组织学相关性和统计支持来协助所有项目。该 PPG 的成果将是 1) 改进微创治疗方案，2) 增加对组织对热处理的反应的基础科学理解，以及 3) 专门用于治疗这些癌症的工程（硬件和软件）的进步。