CRCNS: Crossbeam Transcranial Ultrasound Technology to Stimulate the Deep Brain

CRCNS：交叉束经颅超声技术刺激深部大脑

• 批准号: 10682454
• 负责人: Kim Butts-Pauly
• 金额: $ 15.39万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682454
• 关键词: Addictive Behavior; Animal Model; Animals; Behavior; Biological; Brain; Cephalic; Clinical; Compensation; Computer Models; Computer software; Deep Brain Stimulation; Development; Drug Addiction; Drug Withdrawal Symptoms; Effectiveness; Electroencephalography; Elements; Ensure; Evoked Potentials; Exhibits; Family suidae; Feedback; Functional Magnetic Resonance Imaging; Goals; Health; Hippocampus; Homosynaptic Depression; Human; Image; Institution; Instruction; Magnetic Resonance Imaging; Mediating; Memory; Modality; Modeling; Mus; Neurologic; Neurosciences; Nucleus Accumbens; Pharmaceutical Preparations; Phase; Principal Investigator; Public Health; Qualifying; Rattus; Relapse; Research; Resolution; Resources; Rodent; Science; Slice; Spottings; Stretching; Structure; Structure of paraventricular nucleus of thalamus; System; Technology; Tissues; Transducers; Validation; Withdrawal Symptom; Work; addiction; bone; clinical application; cranium; experimental study; image guided; imaging modality; improved; nervous system disorder; neural; neural circuit; neural stimulation; neuroregulation; nonhuman primate; novel; programs; response; technology development; ultrasound

SUMMARY Numerous neuroscience and clinical applications exist for a noninvasive neuromodulation technology that can reach deep in the brain with high resolution. One compelling clinical application is the treatment of drug addiction, a major public health challenge in the US. In humans, the neural targets for treatment are 1-4 mm3, and thus a critical goal is to stimulate deep in the brain with higher resolutions than currently available with any noninvasive stimulation modality. The goal of this research is the development and experimental validation of computational models for optimization of high resolution deep brain transcranial ultrasound stimulation (TUS) for neuroscience and clinical application. Noninvasive transcranial ultrasound stimulation has been shown to be safe and spatially specific in various animal models. However, current systems are not optimized for high resolution TUS of the deep brain. Computational modeling suggests we can optimize TUS with phased array systems that can be driven in pairs while oriented at 90° to each other and focused to the same point, called “crossbeam.” This improves the stimulation resolution by more than an order of magnitude. In addition, our modeling suggests that we can selectively stimulate neural tissue using a “pinch” or “stretch.” In this project, we will perform a biological validation of crossbeam’s improved effectiveness due to the neural tissue’s sensitivity to “pinch” or “stretch.” Our validated modeling will be used to refine a crossbeam neurostimulation strategy involving optimized array probes. This will allow not only choice of focal depth, but also compensation of phase aberrations resulting from the propagation through the skull bone. The optimized hardware and the developed computational models will be integrated with imaging guidance and validated in skull phantom experiments. RELEVANCE (See instructions): We are developing the technology for improving health through the noninvasive treatment of neurological disorders such as addiction.

概括 对于一种无创神经调节技术存在许多神经科学和临床应用， 可以通过高分辨率到达大脑深处。一种令人信服的临床应用是药物的治疗 成瘾是美国的主要公共卫生挑战。在人类中，治疗的神经靶标为1-4 MM3，因此一个关键的目标是用比当前可用的更高的分辨率刺激大脑深处 任何无创刺激方式。这项研究的目的是开发和实验 验证计算模型，以优化高分辨率深脑经颅超声 神经科学和临床应用的刺激（TU）。无创颅超声刺激 在各种动物模型中已被证明是安全且经常特定的。但是，当前系统是 未针对深脑的高分辨率进行优化。计算建模表明我们可以优化 TUS带有一个分阶段的阵列系统，可以成对驱动，同时在90°彼此之间定向并聚焦 到同一点，称为“横梁”。这将模拟分辨率提高了不止 震级。此外，我们的建模表明我们可以使用A选择性地刺激神经组织 “捏”或“伸展”。在这个项目中，我们将对Crossbeam的改进进行生物学验证 由于神经元组织对“捏”或“拉伸”的敏感性而引起的有效性。我们经过验证的建模将是 用于完善横梁神经刺激策略涉及优化的阵列问题。这将不允许 唯一选择焦点的选择，也只能选择繁殖而产生的相差的补偿 通过头骨骨头。优化的硬件和开发的计算模型将集成 通过成像指导，并在颅骨幻影实验中进行了验证。 相关性（请参阅说明）： 我们正在开发通过神经系统侵入性治疗来改善健康的技术 诸如成瘾之类的疾病。