Technology-based Treatments for Substance Use Disorders

基于技术的药物使用障碍治疗

• 批准号: 10624444
• 负责人: Lisa A. Marsch
• 金额: $ 144.19万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624444
• 关键词: Acceleration; Achievement; Address; Adolescent; Adoption; Adult; Area; Authorization documentation; Awareness; Behavior Therapy; Caring; Clinical; Communication; Computer software; Congresses; Data Analytics; Development; Diagnostic; Discipline; Disease; Dissemination and Implementation; Education; Effectiveness; Emerging Technologies; Ensure; Ethics; Evaluation; Funding; Future; Grant; HIV risk; Health Services Accessibility; Healthcare; Improve Access; Industry; Infrastructure; International; Intervention; Knowledge; Leadership; Link; Measurement; Medical; Mental Health; Mental disorders; Mentorship; Methodology; Methods; Modeling; National Institute of Drug Abuse; Phase; Phenotype; Pilot Projects; Population; Process; Productivity; Publications; Quality of Care; Research; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Resource Sharing; Resources; Risk Behaviors; Science; Substance Use Disorder; System; Technology; Testing; Therapeutic; Training; Treatment outcome; Underrepresented Minority; United States Substance Abuse and Mental Health Services Administration; Work; authority; behavior change; behavioral health; care outcomes; cost; cost effectiveness; digital; digital delivery; digital health; digital intervention; digital platform; digital treatment; diversity and inclusion; dual diagnosis; evidence base; health assessment; health care settings; implementation efforts; innovation; intervention delivery; mobile sensing; next generation; novel; physical conditioning; prevent; scale up; substance use treatment; symposium; synergism; therapeutic target; therapy development; treatment disparity

OVERALL CORE CENTER PROJECT SUMMARY Digital therapeutics that deliver science-based, behavior change interventions targeting substance use disorders (SUDs) and related issues (including HIV risk behavior and mental health disorders) can markedly improve access to care, quality of care, and treatment outcomes, while reducing costs, for a wide array of audiences in diverse settings. Our interdisciplinary group received a P30 “Center of Excellence” grant from NIDA 9 years ago to launch a new research center (the Center for Technology and Behavioral Health [CTBH]). CTBH has led the field in the development, empirical testing, and implementation of digital therapeutics targeting SUDs and related issues. In this renewal application, we propose to build on this work and grow activities to address the most timely and significant research priorities for the field to: (1) enhance our collaborative work with a wide array of scientific, clinical, industry, and governmental partners to scale access to science-based digital therapeutics across the U.S. and beyond; (2) expand activities to link CTBH’s innovative research in digital health measurement to inform personalized digital therapeutics; (3) accelerate research and mentorship on transdiagnostic digital treatments for substance use and co-occurring mental and physical health conditions (CODs); (4) expand research and resources on digital health ethics and (5) broaden the diversity and inclusiveness of digital health researchers by increasing mentorship and representativeness of underrepresented minorities in digital health research. The Overall Aim of the P30 Center is: To integrate expertise across multiple disciplines and provide an infrastructure to enhance the quality, pace of achievement, and impact of innovative scientific research that combines science-based behavior change interventions with state-of-the-science technologies to create, evaluate, and disseminate digital therapeutics targeting SUDs and co-occurring disorders (CODs). CTBH will achieve this Aim via 5 Cores: (1) The Treatment Development and Evaluation Core will provide resources and training to enhance the quality, efficiency, and impact of research and support mechanisms to accelerate the state-of-the science of digital health assessments and therapeutics (2) The Dissemination and Implementation Core will disseminate research methods and findings and advance a scientific understanding of successful implementation of digital therapeutics in diverse settings, (3) The Emerging Technologies and Data Analytics Core will enhance education and research on the application of emerging technologies and data analytics to digital therapeutics and support shared resources to enhance the pace of development, and potency of, digital therapeutics, (4) The Pilot Core will support the development of new areas of research that could progress to larger-scale testing via external funding after the pilot phase, and (5) The Administrative Core will provide programmatic leadership that ensures successful coordination of activities across Cores and an infrastructure to enhance synergy among our interdisciplinary team.

核心中心项目总体概要 数字疗法提供基于科学的、针对药物使用的行为改变干预措施 疾病（SUD）和相关问题（包括艾滋病毒危险行为和精神健康障碍）可以显着 改善获得护理的机会、护理质量和治疗结果，同时降低成本，适用于多种疾病 我们的跨学科小组获得了 P30“卓越中心”资助。 NIDA 9年前启动了一个新的研究中心（技术与行为健康中心[CTBH]）。 CTBH 在数字疗法的开发、实证测试和实施方面处于领先地位 针对 SUD 和相关问题 在此更新应用程序中，我们建议在此工作的基础上继续发展。 旨在解决该领域最及时和最重要的研究优先事项的活动，以：（1）加强我们的 与广泛的科学、临床、行业和政府合作伙伴合作，以扩大获取范围 (2) 扩大与 CTBH 的联系活动 数字健康测量的创新研究为个性化数字治疗提供信息（3）加速； 对物质使用和同时发生的精神和疾病的跨诊断数字治疗的研究和指导 身体健康状况（COD）；（4）扩大数字健康伦理方面的研究和资源；（5）拓宽 通过增加指导和代表性来提高数字健康研究人员的多样性和包容性 P30 中心的总体目标是： 整合少数群体在数字健康研究中的代表性。 跨多个学科的专业知识，并提供基础设施来提高质量和成就速度， 以及创新科学研究的影响，该研究将基于科学的行为改变干预措施与 用于创建、评估和传播针对 SUD 的数字疗法的最先进的技术 并发疾病 (COD) 将通过 5 个核心实现这一目标：(1) 治疗开发和 评估核心将提供资源和培训，以提高研究的质量、效率和影响 和支持机制，以加速数字健康评估和治疗的科学发展水平 (2) 传播和实施核心将传播研究方法和成果并推进 对在不同环境中成功实施数字疗法的科学理解，(3) 新兴技术和数据分析核心将加强有关应用的教育和研究 新兴技术和数据分析到数字疗法并支持共享资源以增强 数字疗法的发展速度和效力，(4) 试点核心将支持数字疗法的发展 新的研究领域可以在试点阶段后通过外部资金进入更大规模的测试，以及 (5) 行政核心将提供计划性领导，确保成功协调 跨核心和基础设施的活动，以增强我们跨学科团队之间的协同作用。

项目成果

The future of digital games for HIV prevention and care.

HIV 预防和护理数字游戏的未来。

• 发表时间: 2017-09
• 作者: Hightow;Muessig, Kathryn E;Bauermeister, José A;LeGrand, Sara;Fiellin, Lynn E
• 通讯作者: Fiellin, Lynn E

Does Tobacco Abstinence Decrease Reward Sensitivity? A Human Laboratory Test.

戒烟会降低奖励敏感性吗？

• 发表时间: 2017-06-01
• 作者: Hughes, John R;Budney, Alan J;Muellers, Sharon R;Lee, Dustin C;Callas, Peter W;Sigmon, Stacey C;Fingar, James R;Priest, Jeff
• 通讯作者: Priest, Jeff

Lifestyle interventions for weight loss among overweight and obese adults with serious mental illness: A systematic review and meta-analysis.

患有严重精神疾病的超重和肥胖成年人减肥的生活方式干预措施：系统评价和荟萃分析。

• 发表时间: 2017
• 影响因子: 7
• 作者: Naslund, John A;Whiteman, Karen L;McHugo, Gregory J;Aschbrenner, Kelly A;Marsch, Lisa A;Bartels, Stephen J
• 通讯作者: Bartels, Stephen J

Problems With Self-Regulation, Family Conflict, and Glycemic Control in Adolescents Experiencing Challenges With Managing Type 1 Diabetes.

经历 1 型糖尿病管理挑战的青少年的自我调节、家庭冲突和血糖控制问题。

• 发表时间: 2018
• 影响因子: 3.6
• 作者: Vaid, Esha;Lansing, Amy Hughes;Stanger, Catherine
• 通讯作者: Stanger, Catherine

Web-Based Cognitive Behavior Therapy for Chronic Pain Patients with Aberrant Drug-Related Behavior: Outcomes from a Randomized Controlled Trial.

针对药物相关行为异常的慢性疼痛患者的基于网络的认知行为疗法：随机对照试验的结果。

• 发表时间: 2018-12-01
• 作者: Guarino, Honoria;Fong, Chunki;Marsch, Lisa A;Acosta, Michelle C;Syckes, Cassandra;Moore, Sarah K;Cruciani, Ricardo A;Portenoy, Russell K;Turk, Dennis C;Rosenblum, Andrew
• 通讯作者: Rosenblum, Andrew