Core A: ADMINISTRATIVE

核心A：行政

• 批准号: 8234231
• 负责人: DORIT HANEIN
• 金额: $ 50.52万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8234231
• 关键词: Accounting; Actins; Adhesions; Administrative Personnel; Administrator; Back; Bacteria; Budgets; Cell physiology; Cells; Cellular biology; Collaborations; Communication; Computer software; Computers; Consult; Consultations; Cytoskeleton; Data; Documentation; Electronic Mail; Emerging Technologies; Engineering; Ensure; Ethers; Faculty; Feedback; Fostering; Freezing; Funding; Future; Goals; Grant; High Performance Computing; Human Resources; Image; Individual; Institution; International; Interruption; Joints; Journals; Laboratories; Leadership; Learning; Letters; Light; Link; Maintenance; Mechanics; Methodology; Molecular; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; Peer Review; Polymers; Postdoctoral Fellow; Preparation; Printing; Process; Productivity; Progress Reports; Publications; Published Comment; Reagent; Reporting; Research; Research Personnel; Resolution; Resources; Right-On; Role; Sampling; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Security; Signal Transduction; Singapore; Site; Specimen; Structure; Students; Supervision; Technology; Teleconferences; Telephone; Time; Training; Travel; Tubulin; Universities; Update; Visit; Work; Workload; Writing; base; biochemical model; cell motility; cost; experience; graduate student; instrument; interest; light microscopy; meetings; member; novel; physical model; planetary Atmosphere; programs; skills; stem cell differentiation; symposium; web page; web site

B. ADMINISTRATIVE TASKS In addition to routine administrative tasks such as interaction with institutional administrators and the grant accounting personnel, dissemination of printed material, copying, typing, handling correspondence, etc, Core A will be responsible for organizing the following scientific venues and mechanisms, 1. Steering Committee. Drs, Hanein, Danuser, Horwitz, Schwartz, Ginsberg and Volkmann will form the Steering Committee for this Program Project, The steering committee will held 10-15 minutes monthly conference calls, which will be the forum for discussion of all major issues regarding the PPG as well as discussion of the month-to-month scientific progress and future planning. The discussions will include new strategies or directions for the Program Project, emerging technologies, or the impact of major breakthroughs in the field. The Pl will plan and chair these meetings. In fact, these phone meetings as well as exchange of documents via DropboxTM have already been established as the communication instruments for the preparation of this application 2. Scientific Advisory Board (SAB). The Program Project will be supported by the SAB, which will consist of four prominent scientists and leaders in the fields of cell migration, force sensing, high resolution light and/or EM imaging. All SAB members accepted our invitation (see letters). Dr. Kenneth Downing (LBNL at UC Berkeley). His research focuses on the structure and function of tubulin, actin-micretubules interactions, and developing frozen-hydrated specimen preparation methodology for imaging cytoskeleton of small bacteria. Dr. Dennis E. Discher (UPenn). His lab is broadly interested in cell mechanics and polymer engineering, studying among others the underlying principles of controlling stem cell differentiation with novel materials and polymers. Dr. Michael Sheetz (Columbia University and National University of Singapore). An expert in force depending signaling and in quantitative physical and biochemical models determining dynamic cellular function. Dr. Clare M Waterman (NHLBI). Her current research integrates high resolution light microscopy with molecular cell biology to study directed cell migration (qFSM and IPALM). The main function of the SAB is to provide critical feedback en the goals and progress of the research planned and accomplished in the Program Project. The SAB members will attend the Annual Retreat, which will allow them to evaluate the overall progress of the Program Project. Comments will be provided to the PI via teleconference and email correspondence. Members of the SAB will also be consulted by phone from time to time to assist in major decisions concerning the course of the work, and new opportunities, 3. Training and interactions. A critically important level of interaction will be inter-lab visits by graduate students and postdoctoral fellows. These visits have already been initiated and several students/postdoctoral fellows (Danuser's, Horwitz's labs) have visited the Hanein lab to learn the basics of the LM/EM sample preparations. Funds have been requested to facilitate these visits, and past experience demonstrates that these exchanges are extremely productive. The core will also encourage trainees to participate actively in the scientific presentations and discussions. Scientific presentations of data in joint meetings will be primarily done by graduate students and postdocs, with only brief overviews by faculty. The annual retreat (see below) will be another excellent opportunity to deepen the interactions. 4. PPG Administrator. The Program benefits from the expertise of an outstanding administrative assistant, Ms. Debbie Signer. Ms. Signer has excellent organizational skills and has the ability to prioritize workload, meet deadlines, and work with frequent interruptions, and is proficient with the MSOffice Suite and EndNote, on both Macintosh and PC computers. The administrative assistant is provided by SBIMR and will act as PPG administrator and assist Dr. Hanein in all duties outlined above. In her role as Program Project Administrator, Debbie will coordinate the scheduling of the annual retreat and face-to-face meetings of the project leaders, scheduling of video conference call meetings, quarterly and annual reviews to NIGMS, documentation of reviews, dissemination of meeting schedules, budgets, management and the accounting of cere resources. The administrator will facilitate efficient interfacing of the investigators at the various institutions and their grants managements, ether administrative personnel. 5. Monthly video conference call meetings. The seven laboratories (Hanein, Volkmann, Danuser, Horwitz, Ginsberg, Schwartz and Groisman) will have a joint monthly video conference call meetings (the Steering Committee conference calls will precede these meetings), which will include students and post-doctoral fellows presenting their work pertaining to the PPG for discussion. Each meeting will have a short presentation of updates by two of the projects, followed by general discussion, 15 minutes at the end are reserved for trouble-shooting questions, ensuring that reagents, software and technologies shared between the labs are appropriately used. These meetings will be attended by all members of the all laboratories (approximately 25 people). 6. Annual Retreat. An annual review of the Projects and Ceres will be performed at least one month in advance of the non-competing progress report deadline. This review will be carried out in the form of an Annual Retreat attended by all Pis, lab members of the on-site labs, one or two key lab members of the off-site labs, and the SAB members. These retreats will be held at SBIMR in La Jolla, which will limit travel to 50% of the team and thus minimize costs. The Annual Retreat will consist of a full day of presentations by the project leaders, graduate students and pest-doctoral fellows from each laboratory. This retreat will not only assist the investigators in obtaining objective views of their scientific progress and advice to overcome potential obstacles, but will also provide an additional avenue for integrating input of pre- and pest-doctoral fellows. 7. Annual progress report. The Annual Retreat will be the basis for a written annual progress report, in addition to Dr. Hanein's summary and each investigator¿s report. This report will be sent to NIGMS as part of the non-competing renewal process. 8. Scientific publications and Program Project homepage. The principal avenue for public dissemination of the scientific results obtained in the context of this Program Project will be publications in peer-reviewed international journals. The overall objective of the Program Project is to provide important scientific advances and breakthroughs. The Program Project webpage will outline the scientific goals of Program Project, lists and summaries of publications, and available reagents. For software dissemination, links will be maintained to the downlead websites of the Danuser and Volkmann labs. The web page will also link to all the investigator¿s websites and their publications. The website will be created with help of the resources available at the SBMRI for the creation and maintenance of scientific websites. Towards this goal. Dr. Hanein will be directly assisted by the High Performance Computing (HPC) team (Dr. C. Weber and Mr. L. Kasko) she currently supervises. The format and security of the website will also be maintained with the help and expertise at HPC/SBMRI.

B. 行政任务 除了与机构管理人员和拨款会计人员互动、分发印刷材料、复印、打字、处理信件等日常行政任务外，核心 A 将负责组织以下科学场所和机制： 1. 指导委员会Hanein、Danuser、Horwitz、Schwartz、Ginsberg 和 Volkmann 博士将组成该计划项目的指导委员会，指导委员会每月举行 10-15 分钟会议 电话会议，这将是讨论有关 PPG 的所有重大问题以及讨论逐月科学进展和未来规划的论坛，讨论将包括该计划项目的新战略或方向、新兴技术、或该领域重大突破的影响。事实上，这些电话会议以及通过 DropboxTM 交换文件已经成为准备此申请的沟通工具。顾问委员会 (SAB)。将得到 SAB 的支持，该委员会将由细胞迁移、力传感、高分辨率光和/或电磁成像领域的四位杰出科学家和领导者组成。所有 SAB 成员都接受了我们的邀请（见信件）。 Kenneth Downing 博士（加州大学伯克利分校劳伦斯伯克利国家实验室）的研究重点是微管蛋白的结构和功能、肌动蛋白-微管相互作用以及开发冷冻水合样本制备。 小细菌细胞骨架成像方法。 Dennis E. Discher 博士（宾夕法尼亚大学）他的实验室对细胞力学和聚合物非常感兴趣。 工程，研究利用新型材料和聚合物控制干细胞分化的基本原理。 Michael Sheetz 博士（哥伦比亚大学和新加坡国立大学）是力依赖信号传导以及确定动态细胞功能的定量物理和生化模型方面的专家。 Clare M Waterman 博士（NHLBI）目前的研究将高分辨率光学显微镜与分子细胞生物学相结合，以研究定向细胞迁移（qFSM 和 IPALM）。 SAB 的主要职能是就计划项目中计划和完成的研究的目标和进展提供关键反馈。SAB 成员将参加年度务虚会，这将使他们能够评估计划项目的总体进展。我们还将通过电话会议和电子邮件向 PI 提供意见，并会不时通过电话咨询 SAB 成员，以协助做出有关工作进程和新机会的重大决策。 3. 培训和互动。至关重要的互动是研究生和博士后研究员的实验室间访问。这些访问已经开始，一些学生/博士后研究员（Danuser 的、Horwitz 的实验室）已经访问了 Hanein 实验室进行学习。 LM/EM 样品制备的基础知识已被要求为这些访问提供便利，过去的经验表明这些交流也将鼓励学员积极参与科学演示和交流。联席会议上的数据科学展示将主要由研究生和博士后进行，只有简短的讨论。 年度务虚会（见下文）将是加深互动的另一个绝佳机会。 4. PPG 管理员。Debbie Signer 女士的专业知识让该计划受益匪浅。Signer 女士具有出色的组织能力，能够确定工作量的优先顺序、按时完成工作并能应对频繁的干扰。 Macintosh 和 PC 计算机上的 MSOffice Suite 和 EndNote 管理助理是。 由 SBIMR 提供，并将担任 PPG 管理员并协助 Hanein 博士履行上述所有职责。 作为项目项目管理员，黛比将协调项目负责人年度务虚会和面对面会议的安排、视频电话会议的安排、NIGMS 的季度和年度审查、审查记录、会议传播管理员将促进各机构的研究人员及其赠款管理人员和行政人员之间的有效联系。 5. 每月视频电话会议 七个实验室（Hanein、Volkmann、Danuser、Horwitz、Ginsberg、Schwartz 和 Groisman）将召开每月联合视频电话会议（指导委员会电话会议将在这些会议之前举行），其中包括学生和博士后研究员介绍他们与 PPG 相关的工作以供讨论。每次会议都会有两个项目的最新进展的简短介绍，然后进行一般性讨论，最后预留 15 分钟时间。问题解决，实验室之间共享的试剂、软件和技术得到适当使用，这些会议将确保所有实验室的所有成员（约 25 人）参加。 6. 年度静修会。项目和 Ceres 的年度审查将在非竞争性进度报告截止日期之前至少一个月进行。该审查将以年度静修会的形式进行，所有 Pis、实验室均参加。现场实验室的成员、场外实验室的一到两名关键实验室成员以及 SAB 成员这些静修活动将在拉霍亚的 SBIMR 举行，这将限制团队的 50% 的人员出差。年度静修活动将包括来自每个实验室的项目负责人、研究生和害虫博士研究员的一整天的演讲。 这次务虚会不仅有助于研究人员获得对其科学进展的客观看法和克服潜在障碍的建议，而且还将为整合博士前研究员和害虫博士研究员的投入提供额外的途径。 7. 年度进展报告。除了 Hanein 博士的总结和每位研究者之外，年度静修将成为书面年度进展报告的基础。该报告将作为非竞争性更新流程的一部分发送给 NIGMS。 8. 科学出版物和计划项目主页。 该计划项目的总体目标是提供重要的科学进展和突破，该计划项目的网页将概述该计划的科学目标。项目、出版物列表和摘要以及可用试剂的链接将保留到 Danuser 和 Volkmann 实验室的下载网站。该网页还将链接到所有研究者。该网站将在 SBMRI 的可用资源的帮助下创建，以实现这一目标。Hanein 博士将得到高性能计算 (HPC) 团队的直接协助。她目前负责监督的网站格式和安全性也将在 HPC/SBMRI 的帮助和专业知识下进行维护。