Core A: ADMINISTRATIVE

核心A：行政

• 批准号: 8234231
• 负责人: DORIT HANEIN
• 金额: $ 50.52万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8234231
• 关键词: Accounting; Actins; Adhesions; Administrative Personnel; Administrator; Back; Bacteria; Budgets; Cell physiology; Cells; Cellular biology; Collaborations; Communication; Computer software; Computers; Consult; Consultations; Cytoskeleton; Data; Documentation; Electronic Mail; Emerging Technologies; Engineering; Ensure; Ethers; Faculty; Feedback; Fostering; Freezing; Funding; Future; Goals; Grant; High Performance Computing; Human Resources; Image; Individual; Institution; International; Interruption; Joints; Journals; Laboratories; Leadership; Learning; Letters; Light; Link; Maintenance; Mechanics; Methodology; Molecular; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; Peer Review; Polymers; Postdoctoral Fellow; Preparation; Printing; Process; Productivity; Progress Reports; Publications; Published Comment; Reagent; Reporting; Research; Research Personnel; Resolution; Resources; Right-On; Role; Sampling; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Security; Signal Transduction; Singapore; Site; Specimen; Structure; Students; Supervision; Technology; Teleconferences; Telephone; Time; Training; Travel; Tubulin; Universities; Update; Visit; Work; Workload; Writing; base; biochemical model; cell motility; cost; experience; graduate student; instrument; interest; light microscopy; meetings; member; novel; physical model; planetary Atmosphere; programs; skills; stem cell differentiation; symposium; web page; web site

B. ADMINISTRATIVE TASKS In addition to routine administrative tasks such as interaction with institutional administrators and the grant accounting personnel, dissemination of printed material, copying, typing, handling correspondence, etc, Core A will be responsible for organizing the following scientific venues and mechanisms, 1. Steering Committee. Drs, Hanein, Danuser, Horwitz, Schwartz, Ginsberg and Volkmann will form the Steering Committee for this Program Project, The steering committee will held 10-15 minutes monthly conference calls, which will be the forum for discussion of all major issues regarding the PPG as well as discussion of the month-to-month scientific progress and future planning. The discussions will include new strategies or directions for the Program Project, emerging technologies, or the impact of major breakthroughs in the field. The Pl will plan and chair these meetings. In fact, these phone meetings as well as exchange of documents via DropboxTM have already been established as the communication instruments for the preparation of this application 2. Scientific Advisory Board (SAB). The Program Project will be supported by the SAB, which will consist of four prominent scientists and leaders in the fields of cell migration, force sensing, high resolution light and/or EM imaging. All SAB members accepted our invitation (see letters). Dr. Kenneth Downing (LBNL at UC Berkeley). His research focuses on the structure and function of tubulin, actin-micretubules interactions, and developing frozen-hydrated specimen preparation methodology for imaging cytoskeleton of small bacteria. Dr. Dennis E. Discher (UPenn). His lab is broadly interested in cell mechanics and polymer engineering, studying among others the underlying principles of controlling stem cell differentiation with novel materials and polymers. Dr. Michael Sheetz (Columbia University and National University of Singapore). An expert in force depending signaling and in quantitative physical and biochemical models determining dynamic cellular function. Dr. Clare M Waterman (NHLBI). Her current research integrates high resolution light microscopy with molecular cell biology to study directed cell migration (qFSM and IPALM). The main function of the SAB is to provide critical feedback en the goals and progress of the research planned and accomplished in the Program Project. The SAB members will attend the Annual Retreat, which will allow them to evaluate the overall progress of the Program Project. Comments will be provided to the PI via teleconference and email correspondence. Members of the SAB will also be consulted by phone from time to time to assist in major decisions concerning the course of the work, and new opportunities, 3. Training and interactions. A critically important level of interaction will be inter-lab visits by graduate students and postdoctoral fellows. These visits have already been initiated and several students/postdoctoral fellows (Danuser's, Horwitz's labs) have visited the Hanein lab to learn the basics of the LM/EM sample preparations. Funds have been requested to facilitate these visits, and past experience demonstrates that these exchanges are extremely productive. The core will also encourage trainees to participate actively in the scientific presentations and discussions. Scientific presentations of data in joint meetings will be primarily done by graduate students and postdocs, with only brief overviews by faculty. The annual retreat (see below) will be another excellent opportunity to deepen the interactions. 4. PPG Administrator. The Program benefits from the expertise of an outstanding administrative assistant, Ms. Debbie Signer. Ms. Signer has excellent organizational skills and has the ability to prioritize workload, meet deadlines, and work with frequent interruptions, and is proficient with the MSOffice Suite and EndNote, on both Macintosh and PC computers. The administrative assistant is provided by SBIMR and will act as PPG administrator and assist Dr. Hanein in all duties outlined above. In her role as Program Project Administrator, Debbie will coordinate the scheduling of the annual retreat and face-to-face meetings of the project leaders, scheduling of video conference call meetings, quarterly and annual reviews to NIGMS, documentation of reviews, dissemination of meeting schedules, budgets, management and the accounting of cere resources. The administrator will facilitate efficient interfacing of the investigators at the various institutions and their grants managements, ether administrative personnel. 5. Monthly video conference call meetings. The seven laboratories (Hanein, Volkmann, Danuser, Horwitz, Ginsberg, Schwartz and Groisman) will have a joint monthly video conference call meetings (the Steering Committee conference calls will precede these meetings), which will include students and post-doctoral fellows presenting their work pertaining to the PPG for discussion. Each meeting will have a short presentation of updates by two of the projects, followed by general discussion, 15 minutes at the end are reserved for trouble-shooting questions, ensuring that reagents, software and technologies shared between the labs are appropriately used. These meetings will be attended by all members of the all laboratories (approximately 25 people). 6. Annual Retreat. An annual review of the Projects and Ceres will be performed at least one month in advance of the non-competing progress report deadline. This review will be carried out in the form of an Annual Retreat attended by all Pis, lab members of the on-site labs, one or two key lab members of the off-site labs, and the SAB members. These retreats will be held at SBIMR in La Jolla, which will limit travel to 50% of the team and thus minimize costs. The Annual Retreat will consist of a full day of presentations by the project leaders, graduate students and pest-doctoral fellows from each laboratory. This retreat will not only assist the investigators in obtaining objective views of their scientific progress and advice to overcome potential obstacles, but will also provide an additional avenue for integrating input of pre- and pest-doctoral fellows. 7. Annual progress report. The Annual Retreat will be the basis for a written annual progress report, in addition to Dr. Hanein's summary and each investigator¿s report. This report will be sent to NIGMS as part of the non-competing renewal process. 8. Scientific publications and Program Project homepage. The principal avenue for public dissemination of the scientific results obtained in the context of this Program Project will be publications in peer-reviewed international journals. The overall objective of the Program Project is to provide important scientific advances and breakthroughs. The Program Project webpage will outline the scientific goals of Program Project, lists and summaries of publications, and available reagents. For software dissemination, links will be maintained to the downlead websites of the Danuser and Volkmann labs. The web page will also link to all the investigator¿s websites and their publications. The website will be created with help of the resources available at the SBMRI for the creation and maintenance of scientific websites. Towards this goal. Dr. Hanein will be directly assisted by the High Performance Computing (HPC) team (Dr. C. Weber and Mr. L. Kasko) she currently supervises. The format and security of the website will also be maintained with the help and expertise at HPC/SBMRI.

B.管理任务 除了常规的行政任务，例如与机构管理员的互动和赠款会计人员的互动，印刷材料的传播，复制，打字，处理信函等，核心A还将负责组织以下科学场所和机制，1。指导委员会。 Drs，Hanein，Danuser，Horwitz，Schwartz，Ginsberg和Volkmann将组成该计划项目的指导委员会，指导委员会将每月举行10-15分钟 电话会议将是讨论有关PPG的所有主要问题的论坛，并讨论了每月的科学进步和未来计划。讨论将包括针对计划项目，新兴技术的新策略或方向，或该领域的重大突破的影响。 PL将计划和主持这些会议。实际上，这些电话会议以及通过Dropboxtm的文档交换已经被确定为准备本申请的通信工具2。科学咨询委员会（SAB）。该计划项目将由SAB支持，SAB将由四个著名的科学家和领导者组成，该领域的迁移，力传感，高分辨率光和/或EM成像。所有SAB成员都接受我们的邀请（请参阅字母）。 肯尼斯·唐宁（Kenneth Downing）博士（加州大学伯克利分校的LBNL）。他的研究重点是小管蛋白，肌动蛋白 - 米金相互作用的结构和功能，并开发冷冻水合的标本制备 小尺度植物学成像细胞骨架的方法。 Dennis E. Discher博士（Upenn）。他的实验室对细胞力学和聚合物非常感兴趣 工程学，研究以新型材料和聚合物来控制干细胞分化的基本原理。 Michael Sheetz博士（哥伦比亚大学和新加坡国立大学）。根据信号传导以及确定动态细胞功能的定量物理和生化模型的力专家。 Clare M Waterman博士（NHLBI）。她目前的研究将高分辨率的光学显微镜与分子细胞生物学相结合，以研究定向细胞迁移（QFSM和IPALM）。 SAB的主要功能是提供关键的反馈，以实现计划项目中计划和完成的目标和进步。 SAB成员将参加年度务虚会，这将使他们能够评估该计划项目的整体进度。将通过电话会议和电子邮件通信向PI提供评论。 SAB的成员还将不时通过电话咨询，以协助有关工作过程以及新的机会，新的机会， 3。培训和互动。重要的互动水平将是研究生和博士后研究员的LAB访问。这些访问已经开始，几个学生/博士后研究员（丹努斯，霍维茨的实验室）访问了Hanein Lab，以学习LM/EM样本准备工作的基础知识。已要求资金来促进这些访问，过去的经验表明这些交流非常有生产力。核心还将鼓励学员积极参与科学演讲和讨论。联合会议中数据的科学演示将由研究生和博士后进行，只有简短 教师的概述。年度务虚会（见下文）将是加深互动的另一个绝佳机会。 4。PPG管理员。该计划受益于杰出的行政助理黛比·签名人的专家。 Signer女士具有出色的组织技能，并且能够优先考虑工作负载，满足截止日期并经常干扰，并且在Macintosh和PC计算机上都精通MSOFFICE SUITE和ENDNOTE。行政助理是 由SBIMR提供，并将担任PPG管理员，并协助Hanein博士执行上述所有职责。 黛比（Debbie）担任计划项目管理员的角色，将协调项目负责人的年度务虚会和面对面会议的时间表，安排视频会议会议会议，每季度和年度评论，肯定的季度和年度审查，审查记录，会议时间表，预算，预算，预算，管理和CERE Resources的会计。管理员将促进各个机构及其赠款管理以太管理人员的调查人员有效接口。 5。每月的视频电话会议会议。七个实验室（Hanein，Volkmann，Danuser，Horwitz，Ginsberg，Schwartz和Groisman）将举行一次每月一次的视频电话会议会议（指导委员会电话会议之前），将在这些会议之前进行召开），其中包括学生和博物后的工作人员，与Doctoral fellows一起向PPG介绍他们的工作。每次会议将由两个项目进行简短的更新介绍，随后进行了一般讨论，最后15分钟保留用于故障搜索问题，以确保适当使用实验室之间共享的试剂，软件和技术。所有实验室的所有成员（大约25人）将参加这些会议。 6。年度务虚会。对项目和CERES的年度审查将在非竞争进度报告截止日期之前至少在一个月之前进行。这篇审查将以所有PI，现场实验室的实验室成员，现场实验室的一两个关键实验室成员和SAB成员的年度务虚会的形式进行。这些务虚会将在拉霍亚的SBIMR举行，该撤退将限制在团队的50％，从而最大程度地降低成本。年度务虚会包括每个实验室的项目负责人，研究生和害虫旁的研究员的一整天演讲。 这种务虚会不仅将有助于调查人员获得其科学进步和建议以克服潜在障碍的客观观点，而且还将为整合预测前和害虫的投入的途径提供额外的途径。 7。年度进度报告。除了Hanein博士的摘要和每个研究者报告外，年度务虚会还将是书面年度进度报告的基础。该报告将作为非竞争续订过程的一部分发送到NIGM。 8。科学出版物和计划项目主页。公共的主要途径 在该计划项目的背景下获得的科学结果的传播将是经同行评审的国际期刊的出版物。该计划项目的总体目标是提供重要的科学进步和突破。计划项目网页将概述计划项目的科学目标，出版物的列表和摘要以及可用试剂。对于软件传播，将维护链接到Danuser和Volkmann Labs的下降网站。该网页还将链接到所有调查员的网站及其出版物。该网站将在SBMRI可用的资源的帮助下创建和维护科学网站。朝着这个目标。 Hanein博士将直接得到她目前监督的高性能计算团队（HPC）团队（HPC）团队（C. Weber博士和L. Kasko先生）。网站的格式和安全性也将在HPC/SBMRI的帮助和专业知识中维护。