Cognitive Neuroscience of Anorexia Nervosa

神经性厌食症的认知神经科学

基本信息

批准号：
8068747
负责人：
JOANNA E STEINGLASS
金额：
$ 17.73万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-03 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8068747
关键词：
Acute Adherence Anorexia Nervosa Attention Award Awareness Behavior Behavioral Binding Body Image Body Weight decreased Characteristics Classification Clinical Clinical Research Cognitive Cognitive deficits Cognitive remediation Complex Conscious Corpus striatum structure Counseling Data Development Diet Disease Eating Eating Behavior Eating Disorders Energy Intake Evaluation Exercise Exhibits Fatty acid glycerol esters Food Foundations Functional Magnetic Resonance Imaging Goals Hospitals Individual Intervention Knowledge Learning Life Maintenance Malnutrition Measures Medial Mediating Medical Memory Mental disorders Mentored Patient-Oriented Research Career Development Award Mentorship Methods Modeling Motor Skills Neural Pathways Neurobiology Neurocognitive Nutritional Obsession Obsessive-Compulsive Disorder Patients Pattern Performance Principal Investigator Process Recovery Relapse Research Research Personnel Research Support Research Training Ritual compulsion Role Schizophrenia Severity of illness Shapes Starvation Stereotyping Symptoms Techniques Temporal Lobe Testing Thinking Training Unconscious State Underweight Ursidae Family Weight Weight Gain Woman base cognitive function cognitive neuroscience eating pathology effective therapy experience feeding habit learning improved innovation mortality neural circuit neuroimaging neuropsychological programs psychologic response restoration skills tool trait

项目摘要

DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a serious psychiatric illness characterized by a relentless but irrational concern about becoming fat, and extreme distortions in the perception of body shape and weight. The eating-related thoughts and behaviors of individuals with AN are repetitive, stereotyped, and extremely resistent to change, even after weight normalization. The persistence of these patterns of thought and behavior are likely related to the high relapse rate seen in this illness. The purpose of this Mentored Patient-Oriented Research Career Development Award (MPORCDA) is to develop and execute a program of research investigating neurocognitive processes in AN, focusing on implicit learning. The broad aim is to explore whether individuals with AN have a disturbance in implicit learning that may constitute a vulnerability to the development of AN and its persistence. The research supported by this award will examine the specific hypothesis that 1) patients with AN have a deficit in implicit learning and are particularly impaired at shifting responses when contingencies change; 2) these disturbances persist, albeit to a lesser degree, even after short-term weight recovery; 3) performance on implicit learning tasks correlates with clinical course; 3) abnormalities in implicit learning are correlated with neural circuitry abnormalities, similar to those seen in OCD; 4) improvement in cognitive deficits in weight restored patients is associated with improved clinical course. A fuller understanding of the basis of the remarkable persistence of the disordered thought and behavior characteristics of AN should provide a foundation for the development of more effective treatments. Under the strong mentorship of Dr. B. Timothy Walsh (for clinical research training and expertise in Anorexia Nervosa), Dr. Yaakov Stern (for training in cognitive neuroscience), and Dr. Bradley Peterson (for training in functional neuroimaging) this MPORCDA will provide the principal investigator with the skills and further research experience to apply advances in translational cognitive neuroscience to the study of AN. The long- term goal of this award is for the candidate to become an expert and independent researcher focusing on mechanisms underlying the development and persistence of eating disorders, with special application to anorexia nervosa.

描述（由申请人提供）：神经性厌食症（AN）是一种严重的精神疾病，其特征是对变胖的持续但非理性的担忧，以及对身体形状和体重的感知的极度扭曲。 AN 患者与饮食相关的想法和行为是重复的、刻板的，并且极难改变，即使在体重正常化之后也是如此。这些思维和行为模式的持续存在可能与这种疾病的高复发率有关。这项以患者为导向的研究职业发展奖 (MPORCDA) 的目的是开发和执行一项研究项目，调查 AN 中的神经认知过程，重点关注内隐学习。总体目标是探讨 AN 患者的内隐学习是否存在障碍，这种障碍可能会导致 AN 的发展及其持续存在。该奖项支持的研究将检验以下具体假设：1）AN 患者在内隐学习方面存在缺陷，并且在突发事件发生变化时，其反应变化尤其受到损害； 2）即使在短期体重恢复后，这些障碍仍然存在，尽管程度较轻； 3）内隐学习任务的表现与临床过程相关； 3）内隐学习的异常与神经回路异常相关，类似于强迫症中所见的情况； 4）体重恢复患者认知缺陷的改善与临床病程的改善相关。更全面地了解 AN 紊乱思维和行为特征显着持续存在的基础，应该为开发更有效的治疗方法奠定基础。在 B. Timothy Walsh 博士（神经性厌食症临床研究培训和专业知识）、Yaakov Stern 博士（认知神经科学培训）和 Bradley Peterson 博士（功能神经影像培训）的大力指导下，该 MPORCDA 将为主要研究者提供技能和进一步的研究经验，将转化认知神经科学的进展应用于 AN 的研究。该奖项的长期目标是让候选人成为专家和独立研究员，专注于饮食失调发展和持续的机制，特别适用于神经性厌食症。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

On Weight and Waiting: Delay Discounting in Anorexia Nervosa Pretreatment and Posttreatment.

DOI：
10.1016/j.biopsych.2014.12.016
发表时间：
2015-11-01
期刊：
Biological psychiatry
影响因子：
10.6
作者：
Decker JH;Figner B;Steinglass JE
通讯作者：
Steinglass JE

Treatment of obsessive-compulsive disorder complicated by comorbid eating disorders.

治疗伴有共病饮食失调的强迫症。

DOI：
10.1080/16506073.2012.751124
发表时间：
2013
期刊：
Cognitive behaviour therapy
影响因子：
4.7
作者：
Simpson,HBlair;Wetterneck,ChadT;Cahill,ShawnP;Steinglass,JoannaE;Franklin,MartinE;Leonard,RachelC;Weltzin,TheodoreE;Riemann,BradleyC
通讯作者：
Riemann,BradleyC

Decreased feedback learning in anorexia nervosa persists after weight restoration.

神经性厌食症的反馈学习减少在体重恢复后仍然存在。

DOI：
10.1002/eat.22709
发表时间：
2017-04
期刊：
The International journal of eating disorders
影响因子：
0
作者：
Foerde K;Steinglass JE
通讯作者：
Steinglass JE

Capacity to delay reward differentiates obsessive-compulsive disorder and obsessive-compulsive personality disorder.

DOI：
10.1016/j.biopsych.2013.09.007
发表时间：
2014-04-15
期刊：
BIOLOGICAL PSYCHIATRY
影响因子：
10.6
作者：
Pinto, Anthony;Steinglass, Joanna E.;Greene, Ashley L.;Weber, Elke U.;Simpson, H. Blair
通讯作者：
Simpson, H. Blair

Temporal discounting across three psychiatric disorders: Anorexia nervosa, obsessive compulsive disorder, and social anxiety disorder.

三种精神疾病的时间贴现：神经性厌食症、强迫症和社交焦虑症。

DOI：
10.1002/da.22586
发表时间：
2017-05
期刊：
Depression and anxiety
影响因子：
7.4
作者：
Steinglass JE;Lempert KM;Choo TH;Kimeldorf MB;Wall M;Walsh BT;Fyer AJ;Schneier FR;Simpson HB
通讯作者：
Simpson HB