Emotional Acceptance Behavior Therapy for Anorexia Nervosa

神经性厌食症的情绪接受行为疗法

• 批准号: 7424161
• 负责人: MARSHA D MARCUS
• 金额: $ 22.28万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-28 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7424161
• 关键词: Acute; Adherence; Adolescence; Adolescent; Adult; Aftercare; Age; Anorexia Nervosa; Awareness; Behavior; Behavior Therapy; Behavioral; Body Weight; Body mass index; Caring; Client satisfaction; Clinical Management; Clinical Treatment; Cognitive Therapy; Coupled; Crows; Data; Development; Drops; Eating; Eating Disorders; Emotional; Enrollment; Feedback; Funding; Future; Goals; Individual; Inpatients; Insurance; Intervention; Investigation; Lead; Length of Stay; Location; Manuals; Measures; Monitor; Morbidity - disease rate; Outpatients; Participant; Patients; Phase; Pilot Projects; Psychopathology; Public Health; Publishing; Quality of life; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Rate; Recruitment Activity; Relapse; Relative (related person); Reporting; Research; Research Personnel; Risk; Role; Services; Shapes; Short-Term Course; Standards of Weights and Measures; Structure; Symptoms; Techniques; Testing; Treatment Protocols; Underweight; United States; Weight; Work; base; design; follow-up; innovation; mortality; negative emotional state; novel; nutrition; prescription document; prescription procedure; programs; response; restoration; satisfaction; severe mental illness; theories; therapy adherence; therapy development; week trial

DESCRIPTION (provided by applicant): Anorexia nervosa (AN) is a serious mental illness characterized by significant morbidity and mortality. Yet, there is little evidence to guide treatment, particularly for older adolescents and adults, who comprise the majority of patients. Thus the overall objective of the work described in this application is to develop and evaluate the preliminary efficacy of a new psychotherapeutic intervention for older adolescents and adults with AN. Emotional Acceptance Behavior Therapy (EABT) for AN is based on a research informed conceptualization of AN that emphasizes the role of anorexic behaviors in helping patients avoid negative emotional states that are perceived as overwhelming and intolerable. The intervention incorporates behavioral principles to promote restoration of adequate nutrition and an acceptable body weight, and strategies to increase emotional awareness and reduce the emotional avoidance that perpetuates AN. Two phases of treatment development are proposed. First, the investigators will draft a treatment manual and adherence measure, and pre-test the intervention with 6-8 patients. In the second phase, the preliminary efficacy of EABT will be evaluated by treating 30 AN patients age > 17 years in an open 22 week trial. Participants will be assessed at baseline, post-treatment and 3- and 6- months after treatment. It is hypothesized that EABT will be associated acceptable rates of client satisfaction and treatment attrition, and improvements in eating disorder symptoms, other psychiatric symptoms, emotional avoidance, and quality of life at post-treatment. It also is hypothesized that EABT will be associated with improvements in eating disorder symptoms, other psychiatric symptoms, emotional avoidance, and quality of life at 3- and 6-month post- treatment follow-up. If hypotheses are confirmed, the investigators will propose a full-scale randomized controlled trial of EABT in a subsequent application. The proposed work is significant as an effort to develop and systematically evaluate the acceptability and preliminary efficacy of a novel, theory-driven outpatient psychotherapeutic intervention for older adolescents and adults with AN. Findings may lead to an efficacious treatment for AN, a critical public health problem.

描述（由申请人提供）：神经性厌食症（AN）是一种严重的精神疾病，其特点是发病率和死亡率很高。然而，几乎没有证据可以指导治疗，特别是对于占患者大多数的老年青少年和成年人。因此，本申请中描述的工作的总体目标是开发和评估新的心理治疗干预措施对患有 AN 的老年青少年和成人的初步疗效。 AN 的情绪接受行为疗法 (EABT) 基于对 AN 的研究知情概念化，强调厌食症行为在帮助患者避免被认为压倒性和难以忍受的负面情绪状态方面的作用。该干预措施结合了促进恢复充足营养和可接受体重的行为原则，以及提高情绪意识和减少导致 AN 持续存在的情绪回避的策略。提出了治疗开发的两个阶段。首先，研究人员将起草治疗手册和依从性措施，并对 6-8 名患者进行干预预测试。在第二阶段，将通过在一项为期 22 周的开放试验中治疗 30 名年龄 > 17 岁的 AN 患者来评估 EABT 的初步疗效。参与者将在基线、治疗后以及治疗后 3 个月和 6 个月时接受评估。据推测，EABT 将与可接受的客户满意度和治疗减员率以及饮食失调症状、其他精神症状、情绪回避和治疗后生活质量的改善相关。还假设 EABT 与饮食失调症状、其他精神症状、情绪回避以及治疗后 3 个月和 6 个月随访时的生活质量的改善有关。如果假设得到证实，研究人员将在后续申请中提出对 EABT 进行全面随机对照试验。拟议的工作具有重要意义，因为它致力于开发和系统评估一种新颖的、理论驱动的门诊心理治疗干预措施，用于治疗患有 AN 的老年青少年和成人，并系统地评估其可接受性和初步疗效。研究结果可能会为 AN 这一严重的公共卫生问题提供有效的治疗方法。