Training and Mentoring in Neurocognitive Mechanisms of Eating Disorders

饮食失调神经认知机制的培训和指导

基本信息

批准号：
10465091
负责人：
JOANNA E STEINGLASS
金额：
$ 12.21万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10465091
关键词：
Address Adolescent Adult Anorexia Nervosa Attention Avoidance Learning Award Behavior Behavioral Mechanisms Behavioral Research Biological Markers Biomedical Research Brain Choice Behavior Clinical Clinical Investigator Clinical Research Cognitive Collaborations Complement Complex Computational Science Computer Models Computing Methodologies Corpus striatum structure Cues Data Analytics Decision Making Development Diffusion Dorsal Eating Eating Disorders Evaluation Eye Faculty Food Functional Magnetic Resonance Imaging Functional disorder Funding Future Generations Goals Habits Health Care Costs Human Individual Knowledge Lead Learning Link Longitudinal Studies Measures Medical Students Mental disorders Mentors Mentorship Methodology Methods Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Modeling Neurobiology Neurocognitive Neurosciences Operant Conditioning Pathway interactions Pilot Projects Postdoctoral Fellow Process Program Development Psychological reinforcement Public Health Research Research Personnel Research Training Rewards Role Scientist System Teenagers Testing Time Training Training Programs United States National Institutes of Health Wages Work base biobehavior brain behavior career cognitive neuroscience experience functional MRI scan gaze improved interest maladaptive behavior mortality neural circuit neuromechanism novel patient oriented research pre-doctoral programs recruit relating to nervous system research and development restrictive eating sensory stimulus skills tool

Address Adolescent Adult Anorexia Nervosa Attention Avoidance Learning Award Behavior Behavioral Mechanisms Behavioral Research Biological Markers Biomedical Research Brain Choice Behavior Clinical Clinical Investigator Clinical Research Cognitive Collaborations Complement Complex Computational Science Computer Models Computing Methodologies Corpus striatum structure Cues Data Analytics Decision Making Development Diffusion Dorsal Eating Eating Disorders Evaluation Eye Faculty Food Functional Magnetic Resonance Imaging Functional disorder Funding Future Generations Goals Habits Health Care Costs Human Individual Knowledge Lead Learning Link Longitudinal Studies Measures Medical Students Mental disorders Mentors Mentorship Methodology Methods Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Modeling Neurobiology Neurocognitive Neurosciences Operant Conditioning Pathway interactions Pilot Projects Postdoctoral Fellow Process Program Development Psychological reinforcement Public Health Research Research Personnel Research Training Rewards Role Scientist System Teenagers Testing Time Training Training Programs United States National Institutes of Health Wages Work base biobehavior brain behavior career cognitive neuroscience experience functional MRI scan gaze improved interest maladaptive behavior mortality neural circuit neuromechanism novel patient oriented research pre-doctoral programs recruit relating to nervous system research and development restrictive eating sensory stimulus skills tool

展开

项目摘要

The overall aim of this K24 Mid-Career Investigator Award in Patient-Oriented Research, “Training and Mentoring in Neurocognitive Mechanisms of Eating Disorders,” is to allow me (Joanna Steinglass MD) to continue to expand my programmatic line of clinical research and mentoring in eating disorders. My work examines the neural mechanisms of Anorexia Nervosa (AN) and develops mechanism-based novel treatment approaches. The field of eating disorders in general, and AN in particular, has an urgent need for more biobehavioral research, and I am well poised to mentor aspiring clinical investigators in this understudied field. Advances in neuroscience create a timely opportunity for a new generation of clinical work identifying biomarkers and treatment targets. I have built a program of research that involves close collaboration with world-class cognitive neuroscientists, and examines the link between brain and behavior in adolescents and adults with AN. This work has opened new avenues of research for the field, and numerous new collaborators have sought my mentorship. Through this K24, I will develop the skills to examine the brain in more sophisticated ways, learning cutting edge skills in cognitive neuroscience, emphasizing computational approaches, and applying them to the study of AN. My currently funded research includes two conceptually- linked R01s examining neural mechanisms of food choice. This K24 will leverage that work to support current mentees and develop new mentorship opportunities. The Research Plan will serve as a platform for the development of mentees, and for advancing my research to pursue future funding in mechanisms of illness and treatment. The training plan includes participation in advanced seminars, collaborations with established and new colleagues to apply new methodologies to the study of AN, and advanced training in relevant computational science. The Mentoring Plan emphasizes new efforts with post-doctoral trainees (psychiatric residents and fellows) and continuation of efforts with trainees at various levels of development: pre-doctoral trainees (medical students), and junior faculty. Through my activities it is hoped that the understanding of the neurobiological underpinnings of AN will improve, and these advances in mechanism will lead to opportunities for development of new treatments. I will contribute to these advances through my research and collaborations with colleagues, and through my training of future clinical investigators.

这项K24中级研究员奖的总体目的是以患者为导向的研究，“培训和在饮食失调的神经认知机制中进行指导，“是为了让我（Joanna Steinglass MD）继续扩大我的临床研究和饮食失调心理的程序化系列。我的工作检查神经性厌食的神经机制（AN）并开发基于机制的新型治疗方法。一般的饮食失调领域，尤其是一个领域，迫切需要更多 Biobehavioral Research，我对这个知识领域的心理有抱负的临床研究人员有利。神经科学的进步为新一代的临床工作提供了及时的机会生物标志物和治疗靶标。我已经建立了一个研究计划，涉及与世界一流的认知神经科学家，并研究青少年和行为之间的联系成人这项工作为该领域开辟了新的研究途径，许多新的合作者已经熟练了我的精神训练。通过此K24，我将发展更多的技能，以更多地检查大脑软化方式，学习认知神经科学中的尖端技能，强调计算接近，并将其应用于An的研究。我目前资助的研究包括两个概念 - 链接的R01检查食物选择的神经机制。该K24将利用这项工作来支持当前 Menees并发展新的指导机会。该研究计划将作为月经的发展，并推进我的研究以寻求疾病机制的未来资金和治疗。培训计划包括参与高级半手，与已建立和新的合作同事将新方法应用于相关计算的AN和高级培训的研究科学。指导计划强调了博士后学员（精神病居民和研究员）以及在各种发展水平的学员中努力的努力：博士前学员（医学生）和初级教师。通过我的活动，希望对神经生物学的基础意志有所改善，这些机制的进步将导致机遇用于开发新治疗。我将通过我的研究和合作为这些进步做出贡献与同事一起，通过我对未来临床研究人员的培训。