Training and Mentoring in Neurocognitive Mechanisms of Eating Disorders

饮食失调神经认知机制的培训和指导

基本信息

批准号：
10221514
负责人：
JOANNA E STEINGLASS
金额：
$ 12.24万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-20 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10221514
关键词：
Address Adolescent Adult Anorexia Nervosa Attention Avoidance Learning Award Behavior Behavioral Mechanisms Behavioral Research Biological Markers Biomedical Research Brain Choice Behavior Clinical Clinical Investigator Clinical Research Cognitive Collaborations Complement Complex Computational Science Computer Models Computing Methodologies Corpus striatum structure Cues Data Analytics Decision Making Development Diffusion Dorsal Eating Eating Disorders Evaluation Eye Faculty Food Functional Magnetic Resonance Imaging Functional disorder Funding Future Generations Goals Habits Health Care Costs Human Individual Knowledge Lead Learning Link Longitudinal Studies Measures Medical Students Mental disorders Mentors Mentorship Methodology Methods Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Modeling Neurobiology Neurocognitive Neurosciences Operant Conditioning Pathway interactions Pilot Projects Postdoctoral Fellow Process Program Development Psychological reinforcement Public Health Research Research Personnel Research Training Rewards Role Scientist System Teenagers Testing Time Training Training Programs United States National Institutes of Health Wages Work base biobehavior brain behavior career cognitive neuroscience experience functional MRI scan gaze improved interest mortality neural circuit neuromechanism novel patient oriented research pre-doctoral programs recruit relating to nervous system research and development restrictive eating sensory stimulus skills tool

项目摘要

The overall aim of this K24 Mid-Career Investigator Award in Patient-Oriented Research, “Training and Mentoring in Neurocognitive Mechanisms of Eating Disorders,” is to allow me (Joanna Steinglass MD) to continue to expand my programmatic line of clinical research and mentoring in eating disorders. My work examines the neural mechanisms of Anorexia Nervosa (AN) and develops mechanism-based novel treatment approaches. The field of eating disorders in general, and AN in particular, has an urgent need for more biobehavioral research, and I am well poised to mentor aspiring clinical investigators in this understudied field. Advances in neuroscience create a timely opportunity for a new generation of clinical work identifying biomarkers and treatment targets. I have built a program of research that involves close collaboration with world-class cognitive neuroscientists, and examines the link between brain and behavior in adolescents and adults with AN. This work has opened new avenues of research for the field, and numerous new collaborators have sought my mentorship. Through this K24, I will develop the skills to examine the brain in more sophisticated ways, learning cutting edge skills in cognitive neuroscience, emphasizing computational approaches, and applying them to the study of AN. My currently funded research includes two conceptually- linked R01s examining neural mechanisms of food choice. This K24 will leverage that work to support current mentees and develop new mentorship opportunities. The Research Plan will serve as a platform for the development of mentees, and for advancing my research to pursue future funding in mechanisms of illness and treatment. The training plan includes participation in advanced seminars, collaborations with established and new colleagues to apply new methodologies to the study of AN, and advanced training in relevant computational science. The Mentoring Plan emphasizes new efforts with post-doctoral trainees (psychiatric residents and fellows) and continuation of efforts with trainees at various levels of development: pre-doctoral trainees (medical students), and junior faculty. Through my activities it is hoped that the understanding of the neurobiological underpinnings of AN will improve, and these advances in mechanism will lead to opportunities for development of new treatments. I will contribute to these advances through my research and collaborations with colleagues, and through my training of future clinical investigators.

K24 职业生涯中期研究者奖以患者为导向的研究的总体目标是“培训和饮食失调的神经认知机制的指导”是为了让我（乔安娜·斯坦格拉斯医学博士）能够继续扩大我在饮食失调方面的临床研究和指导的计划范围。检查神经性厌食症 (AN) 的神经机制并开发基于机制的新型治疗方法饮食失调领域，特别是AN，迫切需要更多的方法。生物行为研究，我已经准备好指导这个待研究领域有抱负的临床研究人员。神经科学的进步为新一代临床工作创造了及时的机会我制定了一个涉及与生物标志物和治疗目标密切合作的研究计划。世界一流的认知神经科学家，研究了青少年和青少年的大脑与行为之间的联系这项工作为该领域开辟了新的研究途径，并吸引了许多新的合作者。通过这个 K24，我将培养更多地检查大脑的技能。复杂的方法，学习认知神经科学的前沿技能，强调计算我目前资助的研究包括两个概念：链接的 R01 检查食物选择的神经机制，该 K24 将利用这项工作来支持当前的工作。研究计划将作为一个平台。受训者的发展，以及推进我的研究以寻求疾病机制的未来资助和治疗。培训计划包括参加高级研讨会、与现有和新成立的机构合作同事们将新的方法应用于 AN 的研究，并进行相关计算的高级培训指导计划强调博士后实习生（精神病学住院医师和精神病学住院医师）的新努力。研究员）并继续与处于不同发展水平的受训人员一起努力：博士前受训人员（医学生）和初级教师希望通过我的活动得到理解。 AN 的神经生物学基础将得到改善，这些机制上的进步将带来机遇我将通过我的研究和合作为这些进步做出贡献。与同事一起，以及通过我对未来临床研究人员的培训。