Magnetic Source Imaging and Sensory Behavioral Characterization in Autism

自闭症的磁源成像和感觉行为特征

• 批准号: 8110506
• 负责人: Elysa Jill Marco
• 金额: $ 17.62万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8110506
• 关键词: 11 year old; Address; Affect; Algorithms; Architecture; Auditory; Auditory area; Autistic Disorder; Behavior; Behavior assessment; Behavioral; Biometry; Brain; California; Case-Control Studies; Characteristics; Child; Clinical; Cognitive; Communities; Data; Development; Diagnosis; Diagnostic; Disease; Economics; Emotional; Epilepsy; Etiology; Evaluation; Fingers; Foundations; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Genetic; Goals; Health; Image; Imaging Techniques; Individual; Knowledge; Language; Learning; Life; Magnetic Resonance Imaging; Magnetism; Maps; Measures; Mental Retardation; Neurologist; Neurology; Neurons; Neuropsychology; Neurosciences; Perception; Performance; Phenotype; Population; Principal Investigator; Process; Psychiatry; Radiology Specialty; Relative (related person); Reporting; Research; Research Personnel; Rest; Sampling; San Francisco; Sensory; Sensory Process; Sensory Thresholds; Somatosensory Cortex; Source; Stimulus; Structure; Tactile; Techniques; Testing; Therapy Clinical Trials; Time; Training; Universities; Work; association cortex; autism spectrum disorder; autistic children; blood oxygen level dependent; boys; case control; central coherence; clinical Diagnosis; cognitive neuroscience; disability; insight; instrument; magnetoencephalogram; neuroimaging; neuromechanism; neuropathology; novel; patient oriented; programs; relating to nervous system; response; sensory cortex; social; social communication; theories; treatment planning; treatment trial

DESCRIPTION (provided by applicant): Dr. Elysa Marco is a cognitive-behavioral child neurologist with expertise in the genetics of mental retardation and autism. She is supported by the academic excellence of the University of California, San Francisco's Neurology, Psychiatry, Radiology, and Neuroscience departments. Her long term research objectives are to use magetic source imaging (MSI) to: (1) probe the etiology of autism, (2) facilitate early accurate diagnosis, and (3) create an objective measure of cognitive processing for use in treatment trials. The goal of this study is to ascertain whether individuals with autism show local cortical hyper-excitation that directly correlates with behaviorally observed sensory over-reactivity. The rationale is that individuals with autism have high rates of sensory processing difficulties and previous studies have documented abnormalities in cortical structure and connectivity. The specific aims are to (1) use traditional and advanced MSI techniques to assess early tactile and auditory processing in the primary sensory cortex; and (2) correlate these findings with detailed measures of tactile and auditory sensitivity. MSI spatial adaptive filtering algorithms allows for precise assessment of brain activity in time, space, and in oscillatory frequency. This technique represents a novel and promising extension of previous work in the field. This cross-sectional case-control study will assess sensory processing in boys (9-11 years) with autism and a performance IQ >70 relative to matched healthy controls. Diagnostic evaluation, cognitive testing, objective sensory assessment, MEG, and MRI will be conducted on 20 children with autism and 20 healthy controls. In addition, to contributing to the understanding of sensory processing in autism, this project will support Dr. Marco's training in neuroimaging, neuropsychology, cognitive neuroscience, and biostatistic so that she can become in independent patient oriented researcher. PUBLIC HEALTH RELEVANCE: Autism spectrum disorders (ASD) permeate the social, emotional, and economic life of the affected individual and their community. ASD is now estimated to affect 1 in 150 individuals and it's underlying neural mechanism remain unclear. This project aims to use the advanced technique of magnetic source imaging to reliably measure the temporal, spatial, and frequency characteristics of neual activity in children with autism during sensory perception. This project will contribute to the understanding of autism and to the development of diagnostic and treatment studies for the future.

描述（由申请人提供）：Elysa Marco博士是一名认知行为的儿童神经科医生，在智力低下和自闭症的遗传学方面具有专业知识。她得到了加利福尼亚大学，旧金山神经病学，精神病学，放射学和神经科学系的学术卓越支持。她的长期研究目标是使用Maget Source Imaging（MSI）来：（1）探测自闭症的病因，（2）促进早期准确的诊断，（3）对治疗试验中使用的认知处理的客观度量。这项研究的目的是确定自闭症患者是否显示与行为观察到的感觉过度反应性直接相关的局部皮质高激活。理由是自闭症患者的感觉处理困难率很高，并且先前的研究证明了皮质结构和连通性的异常。具体目的是（1）使用传统和先进的MSI技术来评估主要感觉皮层中的早期触觉和听觉处理； （2）将这些发现与触觉和听觉敏感性的详细指标相关联。 MSI空间自适应滤波算法可以精确地评估时间，空间和振荡频率。这项技术代表了该领域先前工作的新颖而有希望的扩展。这项横截面病例对照研究将评估自闭症男孩（9-11岁）的感觉处理，相对于匹配的健康对照组，具有自闭症和性能> 70。诊断评估，认知测试，客观感觉评估，MEG和MRI将对20名自闭症儿童和20个健康对照进行。此外，为了理解自闭症的感觉处理，该项目将支持Marco博士在神经影像学，神经心理学，认知神经科学和生物统计学方面的培训，以便她可以成为独立的以患者为导向的研究人员。公共卫生相关性：自闭症谱系障碍（ASD）渗透到受影响个人及其社区的社会，情感和经济生活。现在估计ASD会影响150名个人中的1个，而它的基本神经机制尚不清楚。该项目旨在利用磁源成像的先进技术来可靠地测量感觉感知儿童自闭症儿童的临时，空间和频率特征。该项目将有助于对自闭症的理解以及未来的诊断和治疗研究的发展。

项目成果

Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention.

• DOI: 10.3389/fpsyg.2020.618436
• 发表时间: 2020
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: Narayan A;Rowe MA;Palacios EM;Wren-Jarvis J;Bourla I;Gerdes M;Brandes-Aitken A;Desai SS;Marco EJ;Mukherjee P
• 通讯作者: Mukherjee P

Sensory over-responsivity: parent report, direct assessment measures, and neural architecture.

感觉过度反应：家长报告、直接评估措施和神经结构。

• DOI: 10.1186/s13229-019-0255-7
• 发表时间: 2019
• 期刊: Molecular autism
• 影响因子: 6.2
• 作者: Tavassoli,Teresa;Brandes-Aitken,Anne;Chu,Robyn;Porter,Lisa;Schoen,Sarah;Miller,LucyJane;Gerdes,MollyRae;Owen,Julia;Mukherjee,Pratik;Marco,ElysaJ
• 通讯作者: Marco,ElysaJ

White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder.

• DOI: 10.3389/fnana.2015.00169
• 发表时间: 2015
• 期刊: Frontiers in neuroanatomy
• 影响因子: 2.9
• 作者: Chang YS;Gratiot M;Owen JP;Brandes-Aitken A;Desai SS;Hill SS;Arnett AB;Harris J;Marco EJ;Mukherjee P
• 通讯作者: Mukherjee P