Towards a reliable and valid assessment of preteen suicidal thoughts and behavior

对青春期前的自杀想法和行为进行可靠和有效的评估

• 批准号: 10583418
• 负责人: Anthony Spirito
• 金额: $ 79.23万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-09 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583418
• 关键词: 11 year old; 17 year old; Address; Admission activity; Affect; Age; Assessment tool; Behavior; Behavior assessment; Behavioral; Biological Markers; Caring; Cessation of life; Child; Clinical; Clinical assessments; Consensus; Data; Day Care; Development; Discipline of Nursing; Emotional; Ensure; Failure; Feedback; Feeling suicidal; Future; Goals; Health Services Research; Hospitalization; Hospitals; Implicit Association Test; Inpatients; Intervention Studies; Interview; Lead; Measures; Mental disorders; Methods; Minority; National Institute of Mental Health; Onset of illness; Parents; Patient Self-Report; Patients; Population Heterogeneity; Psychiatric therapeutic procedure; Psychiatrist; Psychologist; Psychopathology; Random Allocation; Recommendation; Research; Research Domain Criteria; Research Personnel; Risk; Risk Factors; Safety; Sampling; Self-Injurious Behavior; Series; Services; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Structure; Suicide; Suicide attempt; Symptoms; Teenagers; Testing; Thinking; Time; Work; Youth; adolescent patient; age group; associated symptom; behavioral outcome; child depression; clinical practice; cognitive capacity; critical period; design; emotion regulation; experience; field study; follow-up; high risk population; ideation; improved; improved outcome; informant; innovation; interest; medical schools; multimodality; preadolescence; protective factors; recruit; resilience; response; suicidal; suicidal adolescent; suicidal behavior; suicide rate; symptomatology; theories

Project Summary The preteen years are a critical period in which to study the development of suicidal thoughts and behavior (STB). During this period, youth experience changes in emotion regulation and develop cognitive capacities that include an emerging understanding of the permanence of death, which in turn affect the expression of STB. However, as noted in the 2021 NIMH- Sponsored Research Round Table Series: Risk, Resilience, and Trajectories in Preteen Suicide, research on preteen STB has been hindered by the field’s failure to focus on an accurate, and thorough, assessment of STB in this age group.This application seeks to develop and test a comprehensive approach to the assessment of preteen STB that includes child and parent/guardian self-report, clinician interviews, an implicit association test, a death understanding interview, and observational measures. In order to address this question, this application will examine both concurrent and predictive validity of the assessment approach in preteens receiving intensive psychiatric services (inpatient or partial hospitalization) who have a range of internalizing and externalizing symptoms, as well as a range of STB. We will recruit 360 preteens at Bradley Hospital/Brown Medical School and the Johns Hopkins School of Medicine, ensuring a diverse sample of children. In addition to refining the assessment of preteen STB, we will also: 1) conduct a thorough clinical assessment of related symptomatology to better inform clinical practice, and 2) examine mechanisms hypothesized to underlie preteen STB, using an RDoC-informed approach. We will also examine which co- occurring symptoms and mechanisms significantly improve predictive validity for adverse clinical STB outcomes above that of the STB assessment alone. This assessment approach is innovative in that it is the first study to develop a multi-modal, multi-informant assessment approach for preteen STB including use of real-time observational strategies, as well as an implicit association test. This is significant because we are studying the most high-risk population of preteens with STB and we will be able to delineate mechanisms related to preteen STB. This work addresses: NIMH Strategic Objective 2.1.B “Characterize the emergence and progression of mental illnesses”, 2.2.A “Determining early risk and protective factors and related mechanisms”, and 2.2.B“Developing reliable and robust biomarkers and assessment tools to predict illness onset, and course, across diverse populations”.

项目摘要 青春期是研究自杀思想发展的关键时期 和行为（STB）。在此期间，青年经历了情绪调节和 发展认知能力，包括对 死亡，进而影响STB的表达。但是，如2021年NIMH-所述 赞助研究圆桌会议系列：青春期的风险，韧性和轨迹 自杀，对青春期STB的研究受到了该领域未关注的专注 在这个年龄段中，准确，诚实地评估了STB的评估。此申请试图 开发和测试一种全面的方法来评估青春期STB 儿童和父母/监护人自我报告，临床访谈，隐性关联测试，死亡 了解访谈和观察措施。为了解决这个问题，这个 应用将检查评估方法的并发和预测有效性 接受密集的精神病服务（住院或部分住院）的青春期 一系列内部化和外在的症状以及一系列STB。我们将招募 布拉德利医院/布朗医学院和约翰·霍普金斯学校的360人 医学，确保潜水员的儿童样本。除了完善评估 青春期STB，我们还将：1）对相关的彻底临床评估 症状学以更好地为临床实践提供信息，2）检查了假设的机制 使用RDOC知识的方法来支持青春期的STB。我们还将检查哪个共同 发生症状和机制可显着提高广告的预测有效性 临床STB的结果仅在STB评估上。这种评估方法是 创新的是，这是第一项开发多模式多模式评估的研究 青春期STB的方法，包括使用实时观察策略以及 隐式关联测试。这很重要，因为我们正在研究最高风险的 具有STB的青春期人口，我们将能够描述与 青春期STB。这项工作解决了：NIMH战略目标2.1.b“表征 精神疾病的出现和进展”，2.2.a“决定早期风险和保护性 因素和相关机制”，以及2.2.b“开发可靠，可靠的生物标志物， 评估工具，以预测潜水员人群的疾病发作和过程”。