Neurobiological Underpinnings of Cognitive Deficits in Neurodevelopmental Disorde

神经发育障碍认知缺陷的神经生物学基础

• 批准号: 8005519
• 负责人: ALEXANDRA S POTTER
• 金额: $ 15.38万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8005519
• 关键词: Acute; Adolescent; Adult; Applications Grants; Area; Attention deficit hyperactivity disorder; Award; Back; Behavioral inhibition; Brain; Child Behavior Disorders; Cholinergic Agents; Cognition; Cognitive; Cognitive deficits; Competence; Complement; Corpus striatum structure; Data; Data Analyses; Data Collection; Development; Disease; Dose; Functional Magnetic Resonance Imaging; Funding; Goals; Health; Human; Impaired cognition; Investigation; K-Series Research Career Programs; Knowledge; Manuscripts; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Methods; Methylphenidate; Modeling; Modification; National Institute of Mental Health; Neurobiology; Neurodevelopmental Disorder; Nicotine; Parietal; Pattern; Performance; Pharmaceutical Preparations; Pharmacological Treatment; Placebos; Principal Investigator; Process; Psychopharmacology; Publications; Publishing; Reaction Time; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Resources; Secure; Short-Term Memory; Signal Transduction; Smoking; Supervision; System; Techniques; Testing; Time; Training; Training Activity; United States National Institutes of Health; Work; age related; blood oxygenation level dependent response; career development; cholinergic; cognitive function; design; developmental neurobiology; experience; improved; neural patterning; neurochemistry; novel; performance tests; programs; research and development; skills; young adult

DESCRIPTION (provided by applicant): This application is for a NIMH K23 Mentored Patient Oriented Research Career Development Award. This award would provide the resources necessary to complete the proposed Career Development and Research Activities as outlined in the application. Briefly, the applicant proposes to gain the expertise necessary to establish herself as an independent investigator exploring the developmental neurobiology of child behavior and neurodevelopmental disorders such as ADHD. The applicant will work with her team of mentors to achieve the following three training goals: Training Goal 1: Acquire the knowledge and skills to conduct studies of cognitive function in ADHD within a developmental framework. Training Goal 2: Develop the necessary skills to implement studies using fMRI methodologies to examine changes in cortical activity associated with cognitive processes in ADHD. Training Goal 3: Develop the skills to combine the techniques of fMRI and pharmacological manipulations (i.e. cholinergic drug challenge) to examine the changes in patterns of brain activation related to changes in cognitive function associated with manipulations of the cholinergic system. Upon the completion of this CDA, the applicant will have the necessary skills, expertise, and preliminary data to secure funding (i.e. NIH R01) to develop her research program exploring cholinergic mechanisms of cognitive dysfunction in disorders such as ADHD, which have traditionally been studied using other neurochemical models. PUBLIC HEALTH RELEVANCE: This novel line of research will provide a broader understanding of the neurobiology of ADHD, will further our understanding of the developmental trajectory of cognitive process in ADHD, and may guide the development of new pharmacological treatments for ADHD. In addition, the knowledge gained from this study may contribute to understanding the high rates of smoking in adolescents and adults with ADHD.

描述（由申请人提供）：此申请适用于NIMH K23指导的以患者为导向的研究职业发展奖。该奖项将提供所需的资源，以完成申请中概述的拟议职业发展和研究活动。简而言之，申请人提议获得必要的专业知识，以建立自己为独立研究者，探讨儿童行为和神经发育障碍（例如ADHD）的发育神经生物学。申请人将与她的导师团队合作，实现以下三个培训目标：培训目标1：获得知识和技能，以在发展框架内对ADHD进行认知功能研究。培训目标2：开发使用fMRI方法论实施研究的必要技能，以检查与多动症认知过程相关的皮质活动变化。培训目标3：开发结合FMRI和药理操作技术（即胆碱能药物挑战）的技能，以检查与与胆碱能系统操纵相关的认知功能变化相关的脑激活模式的变化。该CDA完成后，申请人将拥有必要的技能，专业知识和初步数据来获得资金（即NIH R01），以制定她的研究计划，以探索诸如ADHD等疾病的认知功能障碍的胆碱能机制，如传统上是使用其他神经化学模型研究的ADHD。公共卫生相关性：这项新颖的研究将为多动症的神经生物学提供更广泛的了解，将进一步了解多动症中认知过程的发展轨迹，并可能指导ADHD的新药理治疗。此外，这项研究所获得的知识可能有助于了解青少年和患有多动症的成年人的吸烟率。