EFFECT OF ACUTE NICOTINE ADMINISTRATION ON MOTOR PERFORMANCE IN ADHD

急性尼古丁给药对多动症患者运动表现的影响

• 批准号: 7605800
• 负责人: ALEXANDRA S POTTER
• 金额: $ 3.13万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605800
• 关键词: Acute; Adolescent; Adult; Attention deficit hyperactivity disorder; Chronic; Cigarette Smoker; Cognitive; Cognitive deficits; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Individual; Institution; Motor; Nicotine; Performance; Research; Research Personnel; Resources; Risk; Smoking; Source; Symptoms; Tobacco; Tobacco use; United States National Institutes of Health; experience

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescents who suffer from Attention-Deficit/Hyperactivity Disorder (ADHD) appear to be at substantially higher risk of becoming cigarette smokers than non-ADHD adolescents. One reason for this may be that nicotine, the psychoactive ingredient in tobacco, may have beneficial effects on some of the symptoms of ADHD making the experience of smoking more reinforcing for individuals with ADHD. We have preliminary evidence that nicotine has acute positive effects on some of the core cognitive deficits in ADHD. We believe that nicotine may also have positive effects on motor functioning in ADHD, and that the positive effects on nicotine on both cognitive and motor symptoms may contribute substantially to the higher risk of chronic tobacco use/abuse in these adolescents and adults.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 患有注意力缺陷/多动症（ADHD）的青少年似乎比非ADHD青少年更高。原因之一可能是，烟草（烟草中的精神活性成分）可能对ADHD的某些症状产生有益的影响，从而使吸烟的经历更加强化ADHD的人。 我们有初步证据表明，尼古丁对ADHD中一些核心认知缺陷具有急性积极影响。 我们认为，尼古丁也可能对ADHD中的运动功能产生积极影响，并且对尼古丁对认知和运动症状的积极影响可能会导致这些青少年和成年人在慢性烟草使用/滥用的风险上较高。