FUNCTIONAL NEUROANATOMY OF ACUTE NICOTINIC MODULATION OF IMPULSIVITY IN WOMEN

女性冲动的烟碱急性调节的功能神经解剖学

• 批准号: 8166986
• 负责人: ALEXANDRA S POTTER
• 金额: $ 2.65万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166986
• 关键词: Acute; Behavioral; Behavioral Research; Brain; Brain imaging; Cessation of life; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Double-Blind Method; Failure; Female; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Impulsivity; Institution; Knowledge; Magnetic Resonance Imaging; Maintenance; Measures; Modeling; Neuroanatomy; Neurobiology; Nicotine; Pattern; Performance; Pharmaceutical Preparations; Placebos; Process; Randomized; Research; Research Personnel; Resources; Signal Transduction; Smoke; Smoker; Smoking; Smoking Prevention; Source; Testing; United States National Institutes of Health; Woman; Women' s Group; cigarette smoking; drug of abuse; effective intervention; male; neuromechanism; non-smoker; research study; smoking cessation; Acute; Behavioral; Behavioral Research; Brain; Brain imaging; Cessation of life; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Double-Blind Method; Failure; Female; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Impulsivity; Institution; Knowledge; Magnetic Resonance Imaging; Maintenance; Measures; Modeling; Neuroanatomy; Neurobiology; Nicotine; Pattern; Performance; Pharmaceutical Preparations; Placebos; Process; Randomized; Research; Research Personnel; Resources; Signal Transduction; Smoke; Smoker; Smoking; Smoking Prevention; Source; Testing; United States National Institutes of Health; Woman; Women' s Group; cigarette smoking; drug of abuse; effective intervention; male; neuromechanism; non-smoker; research study; smoking cessation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cigarette smoking is the leading cause of preventable death in the U.S. and female smokers have more difficulty quitting smoking than do male smokers. Understanding the factors that relate to vulnerability to smoking, maintenance of smoking, and failure to quit smoking is an important goal of behavioral research. Careful characterization of the neurobiological underpinnings of behavioral factors that contribute to vulnerability to smoking may help to develop more effective interventions for both smoking prevention and smoking cessation. One promising behavioral characteristic related to cigarette smoking in women is impulsivity. Female smokers are known to be more impulsive than non-smokers on several different measures of impulsivity. In addition, acute nicotine has been shown to reduce impulsivity in female non-smokers who are highly impulsive. Recent studies have begun to identify the underlying functional neuroanatomy involved in tasks that measure impulsivity particularly the Stop Signal Task (SST). The goal of this research study is to examine changes in brain activity associated with improvements in impulsivity related to nicotine administration in women. This is a pilot brain imaging study examining patterns of brain activation during performance of the Stop Signal Task (a test of impulsivity) in women smokers and non-smokers. Three groups of women will be studied; high impulsive female smokers, high impulsive female non-smokers, and low impulsive female non-smokers. Each subject will participate in two study days during which they will have their impulsivity assessed while in the MRI scanner. On one day subjects will take nicotine and on one day they will take placebo. Medication will be administered in a double blind fashion and the order of drug and placebo will be randomized. The knowledge gained from this study will provide an important "proof of concept" that the brain activity during the Stop Signal Task as measured by fMRI is sensitive to differences in impulsivity which is modifiable by nicotine. This research will help our understanding of the neural mechanisms of one of the behavioral processes that contribute to the initiation and maintenance of smoking. This model may additionally be useful for the examination of other drugs of abuse.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 吸烟是美国可预防死亡的主要原因，而女性吸烟者比男性吸烟者更难戒烟。 了解与吸烟，维持吸烟和不戒烟有关的因素是行为研究的重要目标。 仔细表征有助于吸烟的行为因素的神经生物学的基础，可能有助于制定更有效的预防和戒烟干预措施。与女性吸烟有关的一种有希望的行为特征是冲动性。 众所周知，女性吸烟者比非吸烟者在几种不同的冲动措施方面更加冲动。 此外，急性尼古丁已被证明可以降低高度冲动的女性非吸烟者的冲动性。 最近的研究已经开始确定参与衡量冲动性尤其是停止信号任务（SST）的任务的潜在功能性神经解剖结构。 这项研究的目的是检查与女性尼古丁给药相关的冲动性改善相关的大脑活动变化。 这是一项试验性脑成像研究，研究了女性吸烟者和非吸烟者的停止信号任务执行过程中大脑激活的模式。 将研究三组​​妇女；高冲动的女性吸烟者，高冲动的女性非吸烟者和低冲动的女性非吸烟者。 每个受试者将参加两个研究日子，在此期间，他们将在MRI扫描仪中评估冲动性。 有一天，受试者将服用尼古丁，有一天他们将安慰剂。 药物将以双盲方式服用，药物和安慰剂的顺序将随机分配。 从这项研究中获得的知识将提供一个重要的“概念证明”，即通过fMRI衡量的停止信号任务中的大脑活动对冲动性的差异敏感，而冲动性的差异是尼古丁可修改的。 这项研究将有助于我们理解有助于吸烟的启动和维持的行为过程之一的神经机制。 该模型还可能可用于检查其他滥用药物。