System Genetics of Male Infertility in the Collaborative Cross

合作杂交中男性不育的系统遗传学

基本信息

批准号：
8205432
负责人：
David Lawrence Aylor
金额：
$ 4.55万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8205432
关键词：
Affect Alleles Architecture Area Beds Biological Models Biology Breeding Candidate Disease Gene Chromosome Mapping Complex Computer Assisted Couples Disease Dissection Environmental Risk Factor Etiology Extinction (Psychology)Fertility Genes Genetic Genetic Epistasis Genetic Variation Genome Genotype Goals Health Histology Human Inbred Mouse Individual Infertility Inherited Knowledge Learning Literature Male Infertility Maps Mentors Methods Molecular Molecular Analysis Molecular Biology Molecular Biology Techniques Mus Parents Pathway interactions Phenotype Population Population Heterogeneity Process Quantitative Trait Loci Recombinants Reporting Reproductive Biology Reproductive Physiology Reproductive Process Research Resources Sperm Count Procedure Structure System Testing Testis Training Validation Work base career career development combinatorial density design fitness insight male mouse genome mouse model offspring programs reproductive skills sperm analysis symposium trait

项目摘要

DESCRIPTION (provided by applicant): The paradox of the genetics underlying infertility is that infertile individuals must have descended from fertile parents. Nonetheless, previous studies have attributed infertility in part to inherited genetic factors. As is the case with many pervasive human health conditions, this results from combinatorial effects of multiple genes, environmental factors and their interactions. Such small effects and interactions are often difficult to detect in both human populations and mouse models. The proposed research will identify genetic variation underlying male infertility using a new mouse population called the Collaborative Cross (CC). The CC is designed to facilitate mapping genes associated with complex traits. During the breeding process, up to 50% of incipient lines stop producing offspring and are declared extinct, and male infertility is a major mechanism of this extinction. This large and diverse population of infertile male mice can be used to better understand the biology and genetics of male infertility and its associated reproductive parameters such as sperm count and testis structure. This project is also valuable to develop new methods that apply to the CC population.

描述（由申请人提供）：不孕不育的遗传学悖论是，不孕不育的个体必定是具有生育能力的父母的后裔。尽管如此，之前的研究仍将不孕症部分归因于遗传因素。与许多普遍存在的人类健康状况一样，这是多种基因、环境因素及其相互作用的组合效应的结果。在人类和小鼠模型中，这种微小的影响和相互作用通常很难检测到。拟议的研究将使用称为协作杂交（CC）的新小鼠群体来识别男性不育症背后的遗传变异。 CC 旨在帮助绘制与复杂性状相关的基因图谱。在繁殖过程中，高达50%的早期品系停止产生后代并被宣布灭绝，而雄性不育是这种灭绝的主要机制。这种庞大且多样化的不育雄性小鼠群体可用于更好地了解雄性不育症的生物学和遗传学及其相关的生殖参数，例如精子计数和睾丸结构。该项目对于开发适用于 CC 群体的新方法也很有价值。