SPF COLONY

SPF菌落

• 批准号: 8357406
• 负责人: JAMES GIBSON ELSE
• 金额: $ 7.43万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357406
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Blood; Breeding; Collection; Funding; Grant; Health; Health Priorities; Human Resources; Macaca; National Center for Research Resources; Performance; Primates; Principal Investigator; Procedures; Production; Recommendation; Reproductive Health; Research; Research Infrastructure; Research Personnel; Resources; Screening procedure; Source; Specific Pathogen Frees; Specific qualifier value; Standardization; Testing; Training; United States National Institutes of Health; Viral; Work; cost; genetic pedigree; germ free condition; juvenile animal; meetings

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The central objective of this project is to breed macaques that are specific pathogen free (SPF and genetically characterized for MHC and full pedigree. These animals are made available as subjects to NIH supported investigators for AIDS related research and contribute to national health priorities. This objective is achieved at the center by utilizing an existing colony of SPF macaques. This colony is expanded via breeding and recruitment of young animals from non-SPF breeding colonies for separation and viral screening. The colonies are virally maintained by routine blood collection for testing at specified intervals. This project provides trained personnel and resources that are necessary to maintain and expand the SPF breeding groups and to manage them in order to optimize health and reproductive performance in support of national health related priorities. The YNPRC works closely with NCRR and the Coordinating Committee to implement recommendations regarding uniform husbandry procedures, standardization of screening tests and such other matters as the committee may deem necessary. To maximize the potential that national priorities for SOF production will be met, the YNPRC works in conjunction with other facilities, and investigators identified by NCRR, to maintain NCRR supported SOF colonies.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目的中心目标是培育无特定病原体（SPF）、具有 MHC 遗传特征和完整谱系的猕猴。这些动物可作为 NIH 支持的研究人员进行艾滋病相关研究的对象，并为国家卫生优先事项做出贡献。 该中心通过利用现有的 SPF 猕猴群来实现这一目标。该群体通过从非 SPF 繁殖群体中繁殖和招募幼年动物进行分离和病毒筛查来扩大。通过定期采血以按指定时间间隔进行测试来维持集落的病毒。该项目提供了维持和扩大 SPF 育种群体并对其进行管理所需的训练有素的人员和资源，以优化健康和繁殖性能，支持国家卫生相关优先事项。 YNPRC 与 NCRR 和协调委员会密切合作，落实有关统一饲养程序、筛查测试标准化以及委员会认为必要的其他事项的建议。为了最大限度地发挥国家特种作战部队生产优先事项的潜力，YNPRC 与其他机构以及 NCRR 确定的调查人员合作，维持 NCRR 支持的特种作战部队殖民地。