SPF COLONY

SPF菌落

• 批准号: 8357406
• 负责人: JAMES GIBSON ELSE
• 金额: $ 7.43万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357406
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Blood; Breeding; Collection; Funding; Grant; Health; Health Priorities; Human Resources; Macaca; National Center for Research Resources; Performance; Primates; Principal Investigator; Procedures; Production; Recommendation; Reproductive Health; Research; Research Infrastructure; Research Personnel; Resources; Screening procedure; Source; Specific Pathogen Frees; Specific qualifier value; Standardization; Testing; Training; United States National Institutes of Health; Viral; Work; cost; genetic pedigree; germ free condition; juvenile animal; meetings

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The central objective of this project is to breed macaques that are specific pathogen free (SPF and genetically characterized for MHC and full pedigree. These animals are made available as subjects to NIH supported investigators for AIDS related research and contribute to national health priorities. This objective is achieved at the center by utilizing an existing colony of SPF macaques. This colony is expanded via breeding and recruitment of young animals from non-SPF breeding colonies for separation and viral screening. The colonies are virally maintained by routine blood collection for testing at specified intervals. This project provides trained personnel and resources that are necessary to maintain and expand the SPF breeding groups and to manage them in order to optimize health and reproductive performance in support of national health related priorities. The YNPRC works closely with NCRR and the Coordinating Committee to implement recommendations regarding uniform husbandry procedures, standardization of screening tests and such other matters as the committee may deem necessary. To maximize the potential that national priorities for SOF production will be met, the YNPRC works in conjunction with other facilities, and investigators identified by NCRR, to maintain NCRR supported SOF colonies.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目的核心目的是繁殖猕猴，这些猕猴（SPF且具有MHC和Full Gedigree的遗传学特征。这些动物可作为NIH支持的研究人员提供有关艾滋病相关研究的受试者，并为国家健康的优先事项做出了贡献。 通过利用现有的SPF猕猴群落来实现该目标。该菌落通过从非SPF繁殖菌落繁殖和招募幼小动物来扩展，以分离和病毒筛查。菌落通过常规血液收集以指定的时间间隔来维持菌落。该项目提供了训练有素的人员和资源，这些人员和资源是维护和扩展SPF育种群体并管理它们，以优化健康和生殖绩效，以支持与国家健康相关的优先事项。 YNPRC与NCRR和协调委员会紧密合作，以实施有关饲养程序，筛查测试的标准化以及委员会认为必要的其他事项的建议。为了最大程度地提高国家对SOF生产的优先级的潜力，YNPRC与其他设施结合使用，以及NCRR确定的调查人员，以维持NCRR支持的SOF菌落。