2010-2011 Enzymes, Coenzymes & Metabolic Pathways Gordon Research Conference

2010-2011 酶、辅酶

• 批准号: 8068318
• 负责人: BRUCE A PALFEY
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8068318
• 关键词: Biochemical Pathway; Biochemical Reaction; Biological; Biology; Communities; Development; Disease; Enzymes; Enzymes and Coenzymes; Evolution; Fostering; Goals; Health; Human; Infection; Isotopes; Kinetics; Metabolic Pathway; Molecular; New Hampshire; Nucleotides; Pathway interactions; Process; RNA; Regulation; Research; Research Personnel; Resort; Schedule; Work; abstracting; catalyst; chemotherapy; design; drug discovery; enzyme mechanism; human disease; meetings; oxidation; posters; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): This proposal is for partial support of the 2010 and 2011 Gordon Research Conferences on "Enzymes, Coenzymes, and Metabolic Pathways", which are scheduled for 18 - 23 July 2009 and 10 - 15 July 2010 at Waterville Valley Resort, Waterville Valley, New Hampshire. The broad and long-term goal of this conference is to foster a molecular- level understanding of biochemical pathways and their associated catalysts. Our specific aim is to present a program of ~36 speakers (6 chosen from poster abstracts), describing recent advances in RNA and Nucleotides, Regulation and Evolution of Pathways, Flavoenzymes, Enzymes in Drug Discovery, Isotope Effects, Biological Oxidations, Dynamics, and Enzyme Mechanisms from Kinetics. Afternoon poster sessions provide a venue for all attendees to present their work and present an opportunity for junior investigators to interact with senior investigators in the field. The significance of this proposal is that the Enzymes GRC serves as the touchstone for the community of researchers investigating the molecular mechanisms of biochemical reactions. The health-relatedness of this application derives from the fact that a molecular description of disease processes is indispensable for the design of chemotherapy. PUBLIC HEALTH RELEVANCE: Vast networks of intricately regulated biochemical pathways underlie all of biology. Discussions at this meeting cover a broad range of pathway-related topics that are important for the development of new therapies for human disease and treatments for human infections.

描述（由申请人提供）：该提案是为了部分支持2010年和2011年戈登（Gordon）关于“酶，辅酶和代谢途径”的研究会议，该会议定于2009年7月18日至23日在2010年7月23日至23日在新罕布什尔州沃特维尔谷沃特维尔谷度假村举行。这次会议的广泛而长期的目标是促进对生化途径及其相关催化剂的分子水平理解。我们的具体目的是介绍一个〜36位扬声器的程序（从海报摘要中选择了6个），描述了RNA和核苷酸的最新进展，途径的调节和演变，途径，黄酮酶，药物发现中的酶，同位素效应，生物氧化，动力学，动力学和动力学机制和酶机制。下午的海报会议为所有与会者提供了一个场所，以介绍他们的工作，并为初级调查人员提供与该领域高级调查员互动的机会。该提议的意义在于，酶GRC是研究生化反应分子机制的研究人员社区的试金石。该应用的健康相关性来自以下事实：疾病过程的分子描述对于化学疗法设计是必不可少的。 公共卫生相关性：整个生物学基础的精致监管的生化途径的庞大网络。在这次会议上的讨论涵盖了广泛的与途径相关的主题，这些主题对于开发人类疾病的新疗法和人类感染治疗很重要。