COBRE: UAF: BIOLOGICAL SPECIMENS AND GENETICS CORE C

COBRE：UAF：生物样本和遗传学核心 C

• 批准号: 8168197
• 负责人: BERT Brandon BOYER
• 金额: $ 8.37万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168197
• 关键词: Alaska Native; Biological; Collection; Communities; Computer Retrieval of Information on Scientific Projects Database; Databases; Disease; Ensure; Epidemiologist; Eskimo Population; Ethics; Etiology; Funding; Genetic; Genotype; Grant; Health Priorities; Heredity; Institution; Investigation; Laboratories; Methods; Obesity; Phase; Privacy; Procedures; Process; Psychologist; Research; Research Personnel; Resources; Risk Factors; Role; Rural; Sampling; Secure; Services; Shipping; Ships; Source; Specimen; Students; Tribal Elders; United States National Institutes of Health; Yup' ik; base; community based participatory research; design; experience; meetings; member

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Biological Specimens and Genetics (BSG) Core provides key services necessary to facilitate collaborative investigations between geneticists, statisticians, epidemiologists, psychologists, and community leaders that are aimed at understanding the interaction of obesity-related risk factors in Yup'ik Eskimos. Additionally, the BSG core provides valuable community, and state-wide services related to the ethical conduct of culturally respectful genetic studies in rural Alaska Native communities. The BSG Core accomplishes these objectives by advising new investigators on the role of heredity in disease etiology, and on the ascertainment of familial relationships using methods that maximize the privacy of participating and non-participating community members. The BSG Core ensures that biological samples are processed to retain sample integrity and stored in a secure facility, and maintains a specimen database to manage and track samples shipped to collaborating laboratories. In addition, the BSG Core provides genotyping expertise to new investigators and students. Finally, the BSG Core will establish a Community Advisory Board that will meet annually, and partner with a National Genetics Advisory Board to establish ethical procedures for the collection and use of biological samples, as well as the dissemination of genetic results using a community-based participatory research framework. The design of the BSG Core is based on our experiences and use of the Genetics Core in phase I of the CANHR study, and on the stated health priorities of our community partners and Tribal Elders.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 生物样本和遗传学 (BSG) 核心提供必要的关键服务，以促进遗传学家、统计学家、流行病学家、心理学家和社区领袖之间的合作调查，旨在了解尤皮克爱斯基摩人肥胖相关风险因素的相互作用。此外，BSG 核心还提供有价值的社区和全州服务，涉及阿拉斯加农村原住民社区中尊重文化的遗传研究的道德行为。 BSG 核心通过就遗传在疾病病因学中的作用以及使用最大限度地保护参与和非参与社区成员隐私的方法确定家庭关系向新研究人员提供建议来实现这些目标。 BSG 核心确保生物样本经过处理以保持样本完整性并存储在安全设施中，并维护样本数据库来管理和跟踪运送到合作实验室的样本。此外，BSG 核心为新研究人员和学生提供基因分型专业知识。最后，BSG 核心将建立一个社区咨询委员会，每年举行一次会议，并与国家遗传学咨询委员会合作，制定生物样本收集和使用的道德程序，以及使用基于社区的遗传信息传播遗传结果。参与性研究框架。 BSG 核心的设计基于我们在 CANHR 研究第一阶段中对遗传学核心的经验和使用，以及我们的社区合作伙伴和部落长老提出的健康优先事项。