INTEGRATIVE PROGRAM IN CNS PATHOPHYSIOLOGY RESEARCH

中枢神经系统病理生理学研究综合计划

• 批准号: 8364908
• 负责人: Ke Jian Liu
• 金额: $ 110.58万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-15 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364908
• 关键词: Area; Basic Science; Biomedical Research; Centers of Research Excellence; Cerebrum; Clinical; Core Facility; Electron Spin Resonance Spectroscopy; Electrophysiology (science); Environment; Functional disorder; Funding; Goals; Grant; Human Resources; Interdisciplinary Study; Lasers; Magnetic Resonance Imaging; Mentors; Microscope; Molecular; National Center for Research Resources; Neuronal Injury; Peer Review; Phase; Photons; Pilot Projects; Principal Investigator; Publications; Research; Research Infrastructure; Research Personnel; Resources; Scanning; Source; Stem cells; Strategic Planning; System; Translational Research; United States National Institutes of Health; Work; cost; neuroimaging; optical imaging; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of this proposal is to transition our existing Phase II COBRE research program and core facilities into a nationally recognized research center that can compete for COBRE-independent NIH center grants. During COBRE Phase I, we succeeded in developing an integrated program in CNS pathophysiology research, and built a 11,000 ft2 dedicated comprehensive neuroimaging facility called Biomedical Research and Integrative Neuroimaging (BRaIN Imaging) Center with a C06 grant from the NCRR. During Phase II, we have upgraded our state-of-the-art multimodal neuroimaging core facilities and used the facilities as the infrastructure for successfully mentoring our junior PIs. During Phase I and II, 6 out of 9 junior PIs in the COBRE successfully obtained a total of 9 new NIH R01 grants. Our peer-reviewed publications and number of grants also increased significantly. In support of this application we have obtained institutional support of ~$500,000 to upgrade our MR scanner into a phase array system and additional ~$400,000 to support the administration of the Phase III program. The funds requested in this application will be used support the Core facilities (personnel and operating costs of three cores - Magnetic Resonance Imaging (MRI), Electron Paramagnetic Resonance Imaging (EPRI) and Optical / Electrophysiology core that has a 2-photon laser scanning microscope) and a Pilot Project Program (PPP). The support of the core facilities and PPP is crucial for bringing our research program to a level competitive at the national level. During the last 8 years, our research program has evolved into four distinct topics: i) Molecular mechanism of BBB disruption; ii) Cerebral oxygenation and its potential as a viable clinical therapy; iii) Stem cells and neuroregeneration; and iv) Molecular mechanisms of neuronal injury. Our research strategy is to build a coherent, synergistic research program under the umbrella of CNS pathophysiology led by the PI of this application who will work with the group leaders of these four topics. The specific aims of the proposed Phase III COBRE are to: (1) maintain and expand the comprehensive neuroimaging core facilities that will support the conduct of basic and translational research in the area of CNS pathophysiology at UNM; and (2) sustain and expand a collaborative and multidisciplinary research environment by enhancing the focus on neuroimaging research and increasing the number of NIH-funded investigators through the proposed overall strategic planning and PPP.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该提案的总体目标是将我们现有的II阶段毛线研究计划和核心设施转变为一个全国认可的研究中心，该研究中心可以争夺独立于鞋底的NIH中心赠款。在第一阶段，我们成功地制定了CNS病理生理学研究的综合计划，并建立了11,000 FT2专用的综合神经影像学设施，称为生物医学研究和综合神经成像（脑成像）中心，并从NCRR中获得了C06赠款。在第二阶段，我们升级了最先进的多模式神经影像核心设施，并将这些设施用作成功指导我们的初级PI的基础设施。在第一阶段和II期间，在毛刺中的9个初级PI中有6个成功获得了9个新的NIH R01补助金。我们经过同行评审的出版物和赠款数量也大大增加。为了支持本申请，我们获得了约500,000美元的机构支持，以将我们的MR Scanner升级到相位阵列系统，并额外约40万美元，以支持III期计划的管理。本应用程序中要求的资金将用于支持核心设施（三个核心的人员和运营成本 - 磁共振成像（MRI），电子顺磁共振成像（EPRI）和光学 /电生理学核心，该核心具有2光子激光扫描显微镜）和一个试验计划（PPP）。核心设施和PPP的支持对于将我们的研究计划提高到国家一级的水平竞争至关重要。在过去的8年中，我们的研究计划已演变为四个不同的主题：i）BBB破坏的分子机制； ii）脑充氧及其作为一种可行的临床疗法的潜力； iii）干细胞和神经变成； iv）神经元损伤的分子机制。我们的研究策略是在该应用程序的PI领导的CNS病理生理学的保护下建立一个连贯的协同研究计划，该计划将与这四个主题的小组负责人合作。拟议的III期cobre的具体目的是：（1）维护和扩展全面的神经影像学设施，这些设施将支持UNM中CNS病理生理学领域的基本和转化研究的进行； （2）通过提高了对神经成像研究的关注，并通过拟议的整体战略规划和PPP来增强对神经成像研究的关注并增加了NIH资助的研究人员的数量，从而维持和扩大了合作和多学科的研究环境。