Integrative Program in CNS Pathophysiology Research

中枢神经系统病理生理学研究综合计划

• 批准号: 8442866
• 负责人: Ke Jian Liu
• 金额: $ 103.74万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-15 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8442866
• 关键词: Applications Grants; Area; Basic Science; Biomedical Research; Center for Translational Science Activities; Centers of Research Excellence; Cerebrum; Clinical; Core Facility; Country; Development; Electron Spin Resonance Spectroscopy; Electrophysiology (science); Environment; Faculty; Functional disorder; Funding; Goals; Grant; Health Sciences; Healthcare; Human Resources; Institution; Interdisciplinary Study; Lasers; Magnetic Resonance Imaging; Mentors; Microscope; Molecular; National Center for Research Resources; Neurology; Neuronal Injury; Neurosciences; New Mexico; Peer Review; Phase; Photons; Pilot Projects; Publications; Request for Applications; Research; Research Infrastructure; Research Personnel; Research Project Grants; Scanning; Science; Stem cells; Strategic Planning; System; Translational Research; United States National Institutes of Health; Universities; Work; base; cost; improved; meetings; member; neuroimaging; optical imaging; pre-clinical; professor; programs; tool

The overall goal of this proposal is to transition our existing Phase Ii COBRE research program and core facilities into a nationally recognized research center that can compete for COBRE-independent NIH center grants. During COBRE Phase I, we succeeded in developing an integrated program in CNS pathophysiology research, and built a 11,000 ft[2] dedicated comprehensive neuroimaging facility called Biomedical Research and Integrative Neuroimaging (BRaIN Imaging) Center with a C06 grant from the NCRR. During Phase II, we have upgraded our state-of-the-art multimodal neuroimaging core facilities and used the facilities as the infrastructure for successfully mentoring our junior PIs. During Phase I and II, 6 out of 9 junior PIs in the COBRE successfully obtained a total of 9 new NIH R01 grants. Our peer-reviewed publications and number of grants also increased significantly. In support of this application we have obtained institutional support of ~$500,000 to upgrade our MR scanner into a phase array system and additional ~$400,000 to support the administration of the Phase III program. The funds requested in this application will be used support the Core facilities (personnel and operating costs of three cores - Magnetic Resonance Imaging (MRI), Electron Paramagnetic Resonance Imaging (EPRI) and Optical / Electrophysiology core that has a 2-photon laser scanning microscope) and a Pilot Project Program (PPP). The support of the core facilities and PPP is crucial for bringing our research program to a level competitive at the national level. During the last 8 years, our research program has evolved into four distinct topics: i) Molecular mechanism of BBB disruption; ii) Cerebral oxygenation and its potential as a viable clinical therapy; iii) Stem cells and neuroregeneration; and iv) Molecular mechanisms of neuronal injury. Our research strategy is to build a coherent, synergistic research program under the umbrella of CNS pathophysiology led by the PI of this application who will work with the group leaders of these four topics. The specific aims of the proposed Phase III COBRE are to: (1) maintain and expand the comprehensive neuroimaging core facilities that will support the conduct of basic and translational research in the area of CNS pathophysiology at UNM; and (2) sustain and expand a collaborative and multidisciplinary research environment by enhancing the focus on neuroimaging research and increasing the number of NIH-funded investigators through the proposed overall strategic planning and PPP.

该提案的总体目标是将我们现有的 II 期 COBRE 研究计划和核心设施转变为国家认可的研究中心，可以竞争独立于 COBRE 的 NIH 中心拨款。在 COBRE 第一阶段期间，我们成功开发了中枢神经系统病理生理学研究的综合项目，并利用 NCRR 的 C06 拨款建造了一个 11,000 英尺[2] 的专用综合神经影像设施，称为生物医学研究和综合神经影像（BRaIN 成像）中心。在第二阶段，我们升级了最先进的多模式神经影像核心设施，并将这些设施用作成功指导初级 PI 的基础设施。在第一阶段和第二阶段期间，COBRE 的 9 名初级 PI 中有 6 名成功获得了总共 9 项新的 NIH R01 资助。我们的同行评审出版物和资助数量也显着增加。为了支持这一应用，我们获得了约 500,000 美元的机构支持，将我们的 MR 扫描仪升级为相控阵系统，并获得了约 400,000 美元的额外支持，以支持第三阶段计划的管理。本申请中请求的资金将用于支持核心设施（三个核心的人员和运营成本 - 磁共振成像 (MRI)、电子顺磁共振成像 (EPRI) 和具有 2 光子激光扫描显微镜的光学/电生理学核心）和试点项目计划（PPP）。核心设施和PPP的支持对于我们的研究项目达到国家级竞争水平至关重要。在过去的 8 年里，我们的研究项目已发展成四个不同的主题： i) BBB 破坏的分子机制； ii) 脑氧合及其作为可行的临床疗法的潜力； iii) 干细胞和神经再生； iv) 神经元损伤的分子机制。我们的研究策略是在中枢神经系统病理生理学的框架下建立一个连贯的、协同的研究计划，由该应用程序的 PI 领导，他将与这四个主题的组长合作。拟议的第三阶段 COBRE 的具体目标是：（1）维护和扩展综合神经影像核心设施，以支持新墨西哥大学中枢神经系统病理生理学领域基础和转化研究的开展； (2) 通过拟议的总体战略规划和 PPP，加强对神经影像学研究的关注并增加 NIH 资助的研究人员数量，维持和扩大协作和多学科研究环境。