LLD Course & Treatment Decisions: Psychosocial Influences

法学博士课程

• 批准号: 7421050
• 负责人: PAUL R DUBERSTEIN
• 金额: $ 14.45万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7421050
• 关键词: Adherence; Adult; Award; Biological; Clinical; Data; Data Analyses; Data Collection; Data Set; Depressed mood; Detection; Doctor of Philosophy; Education; Elderly; Faculty; Feeling suicidal; Funding; Grant; Health; Inpatients; Major Depressive Disorder; Mental Depression; Mentors; Methods; Modeling; Moods; National Institute of Mental Health; Outcome; Patients; Personality; Personality Traits; Physicians; Prevention; Primary Health Care; Principal Investigator; Process; Public Health; Public Housing; Qualitative Methods; Reporting; Research; Risk; Scientist; Site; Social Aspects of Cancer; Social support; Suicide; Suicide prevention; Support of Research; Symptoms; Testing; Therapeutic; accomplished suicide; base; cognitive function; collaborative trial; depressive symptoms; design; experience; geriatric depression; programs; psychosocial; racial difference; skills; social; suicidal behavior

DESCRIPTION (provided by applicant): LLD Course & Treatment Decisions: Psychosocial Influences. In 1999, the Principal Investigator of this K24 application, Paul Duberstein, PhD, began to develop a model that seeks to explain why late-life depression (LLD) so often goes unreported by patients and undetected by their significant others. Key variables in the model are: personality traits, social support, cognitive function, and physical health of both patients and their significant others. Funding from two NIMH grants supported research to test aspects of this model in depressed inpatients (Project 1; "Adult depression, suicidal ideation, and personality," NIMH, R01 MH60285) and primary care patients. (Project 2; "Detecting depressive symptoms in older adults," NIMH R01MH64579). Specifically, those projects hypothesized that people with particular personality traits are less likely to report mood symptoms. Moreover, their mood symptoms are less likely to be detected by others. Analyses of the Project 1 dataset are consistent with these hypotheses. Data collection for Project 2 is completed. The proposed K24 will provide support to extend this program of research, and to support mentoring activities focused on further research regarding LLD. K24 Research Aims: a) to test and refine a model of symptom detection using data collected in these R01s, and submit a new R01 based on these findings; b) to use qualitative and quantitative methods to identify the psychosocial, biological, and sociocultural influences on treatment engagement (e.g., initiation, adherence) and outcomes in LLD. The applicant and his mentees will implement a new study on LLD in public housing residents (Project 3) and conduct secondary analyses of data collected in an NIMH-funded multi-site study called the Prevention of Suicide in Primary Care Elderly - Collaborative Trial (PROSPECT, Project 4). Race differences will be explored in Projects 2-4. K24 Education Aims: a) to develop skills in qualitative methods, and b) to continue the process of enhancing skills as an effective, culturally sensitive mentor to social scientists and physicians. By the end of the Award period, the P.I. will have made a substantial contribution to the conceptualization of the treatment and prevention of LLD, acquired new research and mentoring skills, and developed a national reputation as an outstanding mentor for a diverse array of developing faculty and fellows seeking to study these important public health, clinical, and therapeutic issues.

描述（由申请人提供）：LLD 课程和治疗决策：心理社会影响。 1999 年，该 K24 应用程序的首席研究员 Paul Duberstein 博士开始开发一个模型，试图解释为什么晚年抑郁症 (LLD) 常常不被患者报告，也不被他们的重要他人发现。该模型中的关键变量包括：患者及其重要他人的人格特质、社会支持、认知功能和身体健康。 NIMH 的两项拨款资助了研究，以在抑郁症住院患者（项目 1；“成人抑郁症、自杀意念和人格”，NIMH，R01 MH60285）和初级保健患者中测试该模型的各个方面。 （项目 2；“检测老年人的抑郁症状”，NIMH R01MH64579）。具体来说，这些项目假设具有特定人格特征的人不太可能报告情绪症状。此外，他们的情绪症状不太可能被其他人察觉。项目 1 数据集的分析与这些假设一致。项目2的数据收集已完成。拟议的 K24 将提供支持以扩展该研究计划，并支持专注于 LLD 进一步研究的指导活动。 K24 研究目标：a) 使用这些 R01 中收集的数据测试和完善症状检测模型，并根据这些发现提交新的 R01； b) 使用定性和定量方法来确定心理社会、生物和社会文化对 LLD 治疗参与（例如，开始、坚持）和结果的影响。申请人及其受训者将实施一项关于公共住房居民 LLD 的新研究（项目 3），并对 NIMH 资助的多地点研究中收集的数据进行二次分析，该研究名为初级保健老年人自杀预防 - 合作试验（PROSPECT） ，项目 4）。种族差异将在项目 2-4 中探讨。 K24 教育目标：a) 培养定性方法的技能，b) 继续提高技能，成为社会科学家和医生的有效、文化敏感的导师。奖励期结束时，P.I.将为 LLD 的治疗和预防的概念化做出重大贡献，获得新的研究和指导技能，并为寻求研究这些重要公共卫生的各种发展中的教师和研究员赢得全国声誉，成为杰出的导师，临床和治疗问题。