TREATMENT WITH VIVITROL TO REDUCE SELF-BITING BEHAVIOR IN ADULT RHESUS MACAQUES

用 VIVITROL 治疗减少成年恒河猴的自咬行为

• 批准号: 8173040
• 负责人: DOTY KEMPF
• 金额: $ 6.18万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173040
• 关键词: Adult; Alcoholism; Behavior; Bite; Blood specimen; Code; Computer Retrieval of Information on Scientific Projects Database; Data Analyses; Drug Kinetics; Drug abuse; Drug usage; Funding; General Population; Grant; Health; Hour; Human; Injectable; Injection of therapeutic agent; Injury; Institution; Macaca mulatta; Methods; Naltrexone; Naltrexone hydrochloride; Oral; Phase; Population; Research; Research Personnel; Resources; Self-Injurious Behavior; Source; Therapeutic; Therapeutic Studies; Time; Tissues; United States National Institutes of Health; behavior observation; nonhuman primate; novel; research facility

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Self-injurious behavior (SIB) may be defined as any self-directed behavior that results in tissue injury. The condition occurs in approximately 5-13% of the captive rhesus macaque population with self-biting being the most common expression of the behavior. Additionally, SIB is a significant human health problem, which interestingly occurs in 4% of the general public. Currently, there are no widely accepted treatments for human or nonhuman primate SIB. However, studies with human and nonhuman primates have shown that therapeutic drugs used to treat alcoholism and drug abuse, such as oral naltrexone hydrochloride, are effective in reducing the occurrence of SIB. To date, there have been no studies examining the value of Vivitrol, a long-acting 30 day injectable naltrexone, for the treatment of human or nonhuman primate SIB. A focused study using Vivitrol for SIB may open the exploration of a novel use for Vivitrol in both research facilities and the general public. Methods: A total of twenty adult rhesus macaques (Macaca mulatta) with documented self-injurious behavior will be assigned to one of two groups. Group 1 (n=16): In the first four week treatment phase baseline behavior will be observed and coded according to an established ethogram. Two injections of Vivitrol will be administered with a four week interval between injections. Behavior will be observed and coded. Blood samples will be taken at the time of each Vivitrol injection and at seven day intervals until the end of the study for therapeutic range data analysis The final phase will be a second baseline behavior observation and coding period. Group 2 (n=4): A pharmacokinetic study will be performed with blood sampling occurring at 0, 2, and 8 hours and 1, 5, 7, 10, 14, 17, 21, 25, and 28 days.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 简介：自我伤害行为（SIB）可以定义为导致组织损伤的任何自定向行为。该条件发生在大约5-13％的圈养猕猴种群中，自我咬人是该行为最常见的表达。此外，SIB是一个重大的人类健康问题，有趣的是，这是4％的公众。目前，对于人类或非人类灵长类动物的同胞尚无广泛接受的治疗方法。然而，对人类和非人类灵长类动物的研究表明，用于治疗酒精中毒和药物滥用的治疗药物（例如盐酸盐酸盐）可有效减少SIB的发生。 迄今为止，还没有研究研究人类或非人类灵长类动物SIB的长效30天的长效纳曲酮的Vivitrol的价值。使用Vivitrol进行SIB的重点研究可能会在研究设施和公众中探索新颖的Vivitrol使用。方法：总共有二十种具有记录的自我伤害行为的成年恒河猕猴（Macaca mulatta）将分配给两组之一。 第1组（n = 16）：在前四个星期，将根据已建立的伦理图观察并编码基线行为。两次注射剂的注射将在两次注射之间进行四个星期的间隔。行为将被观察和编码。每次体内注射时将采集血液样本，并在七天的间隔内进行治疗范围数据分析的研究结束，最后阶段将是第二个基线行为观察和编码期。第2组（n = 4）：将在0、2和8小时和1、5、7、10、14、17、21、25和28天进行血液采样时进行药代动力学研究。