RESTING STATE FUNCTIONAL CONNECTIVITY IN CHIMPANZEES

黑猩猩静息态功能连接

• 批准号: 8172373
• 负责人: TODD M PRUESS
• 金额: $ 2.74万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172373
• 关键词: Behavioral; Brain; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Evolution; Functional Magnetic Resonance Imaging; Funding; Grant; Human; Institution; Knowledge; Light; Pan Genus; Reporting; Research; Research Personnel; Resources; Rest; Scanning; Source; Techniques; United States National Institutes of Health; Weight; Work

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. fMRI has been used to detect functionally connected networks in the resting human brain. Because these networks are present both at rest and also in the lightly anesthetized state, it is possible to identify them in lightly anesthetized chimpanzees and compare them with those found in humans to inform our knowledge of the extent to which human and chimpanzee brains are similarly organized. This may help us to identify specializations of human brain connectivity that support human cognitive and behavioral specializations and will also shed light on human brain evolution. During the reporting period, we worked out techniques for correct distortions in the T2*-weighted scans so as to register them accurately to the anatomical T1 scans. In addition, we began studies of connectivity in chimpanzees by seeding selected regions of cortex and identifying territories that show correlated activity.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 fMRI已用于检测静息人脑中功能连接的网络。由于这些网络都存在于静止和轻微麻醉状态，因此可以在轻微麻醉的黑猩猩中识别它们，并将它们与人类发现的人进行比较，以告知我们了解人类和黑猩猩大脑在多大程度上类似地组织的。 这可能有助于我们确定支持人类认知和行为专业的人脑连接性的专业知识，还将阐明人脑的进化。在报告期间，我们制定了在T2*加权扫描中正确扭曲的技术，以便将其准确地注册到解剖学T1扫描中。 此外，我们通过播种皮质的选定区域并鉴定出显示相关活性的领土，从而开始研究黑猩猩的连通性。