Calcium Metabolism in Mexican American Adolescents

墨西哥裔美国青少年的钙代谢

• 批准号: 8101327
• 负责人: Connie Marie Weaver
• 金额: $ 51.05万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8101327
• 关键词: Address; Adolescence; Adolescent; Adult; African American; Age; Asians; Biochemical Markers; Biochemistry; Bone Density; Bone Resorption; Calcium; Calcium Isotopes; Camping; Child; Childhood; Chinese American; Chinese People; Coupled; Data; Diet; Dietary Calcium; Dietary intake; Dihydroxycholecalciferols; Elderly; Equilibrium; Ethnic group; Excretory function; Feces; Female Adolescents; Genetic; Growth; Health; Hispanics; Intestines; Kidney; Kinetics; Knowledge; Life; Life Style; Male Adolescents; Measures; Metabolic; Mexican; Mexican Americans; Minerals; Minority; Minority Groups; Modeling; Nutritional; Osteogenesis; Osteoporosis; Outcome; Physical activity; Physiological; Physiology; Population; Public Health; Questionnaires; Race; Recommendation; Relative (related person); Research; Risk; Role; Serum; Sex Characteristics; Skeleton; Staging; Statistical Models; Urine; Weight; bone; bone mass; bone turnover; boys; calcium absorption; calcium intake; calcium metabolism; caucasian American; falls; girls; prevent; racial and ethnic; racial difference; sex; skeletal; stable isotope; urinary

DESCRIPTION (provided by applicant): We have found significant racial and sex differences in calcium retention and kinetics in adolescents. American black girls had greater calcium retention than white girls (481 vs. 282 mg/d) on current recommended calcium intake as a result of greater net bone formation rates, higher calcium absorption and lower urinary calcium excretion. We also found white boys retain more calcium than girls at all calcium intakes. From these balance and kinetic studies, we have developed a model of the relationship between calcium intake and calcium retention that can be used to estimate calcium requirements for maximal skeletal accretion in adolescents. We are currently studying these relationships in Chinese American adolescents. Chinese boys and girls have greater calcium retention at all calcium intakes than white boys and girls. In this application, we propose to study these relationships in adolescent boys and girls from the Mexican American minority who are the largest group of Hispanics and will soon comprise one-fourth of the U.S. population. We hypothesize that Mexican Americans respond to calcium intake like other minority groups with increased calcium absorption efficiency at low calcium intakes in comparison to white adolescents. The first aim is to establish the calcium requirement in Mexican American girls and boys; the second aim is to establish the relationship between calcium intake and fractional calcium absorption; the third aim is to determine the relative contribution of the intestine, kidney, and bone to calcium retention in Mexican American adolescents and compare these results with those already established in American white, black, and Asian adolescents; and the fourth aim is to develop a model to quantify the effect of calcium intake, race/ethnic group, sex, and sexual maturity on calcium retention. As we have done in our previous studies, we will use stable calcium isotope kinetics coupled with metabolic balance studies conducted as a summer research camp. Optimizing calcium retention during adolescence in both majority and minority populations in the U.S. is a key nutritional strategy to build peak bone mass and reduce lifelong risk of osteoporosis in the elderly U.S. population. PUBLIC HEALTH RELEVANCE: Hispanics will soon comprise one-fourth of the U.S. population. This project will determine the role of dietary calcium in skeletal calcium retention in Mexican American adolescents and will compare these results with what we have found in other racial groups to identify mechanisms responsible for the racial differences. These studies will allow us to determine the calcium intake required for optimal calcium retention during the period of rapid skeletal growth which is a key nutritional strategy to build peak bone mass and reduce lifelong risk of osteoporosis.

描述（由申请人提供）：我们发现青少年钙保留和动力学的种族和性别差异很大。由于净骨形成率更高，钙吸收率更高和尿钙排泄，美国黑人女孩的钙保留量比当前推荐的钙摄入量比白人女孩（481 vs. 282 mg/d）更大。我们还发现白人男孩在所有钙摄入量中都保留了更多的钙。从这些平衡和动力学研究中，我们开发了一种钙摄入量与钙保留之间关系的模型，可用于估计青少年最大骨骼积聚的钙需求。我们目前正在华裔青少年研究这些关系。与白人男孩和女孩相比，中国男孩和女孩的钙摄入量更高。在此应用中，我们建议研究来自墨西哥少数群体的青春期男孩和女孩，这些男孩是最大的西班牙裔人群，并将很快占美国人口的四分之一。我们假设墨西哥裔美国人像其他少数群体一样对钙的摄入反应，而与白人青少年相比，低钙摄入量的钙吸收效率提高。第一个目的是在墨西哥裔美国女孩和男孩中建立钙需求。第二个目的是建立钙摄入量与钙吸收分数之间的关系。第三个目的是确定墨西哥裔美国青少年肠道，肾脏和骨骼对钙保留的相对贡献，并将这些结果与已经在美国白人，黑人和亚洲青少年中建立的结果进行比较。第四个目标是开发一个模型来量化钙摄入量，种族/种族，性别和性成熟度对钙保留的影响。正如我们在先前的研究中所做的那样，我们将使用稳定的同位素动力学以及作为夏季研究营进行的代谢平衡研究。在美国，在大多数人和少数族裔人口中优化钙保留量是建立峰值骨质峰值并降低美国老年人人口骨质疏松症的终生风险的关键营养策略。公共卫生相关性：西班牙裔将很快占美国人口的四分之一。该项目将确定饮食中钙在墨西哥裔美国青少年中的骨骼钙保留率中的作用，并将这些结果与我们在其他种族群体中发现的结果进行比较，以识别负责种族差异的机制。这些研究将使我们能够在快速骨骼生长期间确定最佳钙保留所需的钙摄入量，这是建立峰值骨骼质量并降低骨质疏松症的终生风险的关键营养策略。