DASH-Sodium Trial in Adolescents

青少年 DASH-钠试验

• 批准号: 9424809
• 负责人: Connie Marie Weaver
• 金额: $ 14.9万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9424809
• 关键词: 15 year old; Acid-Base Equilibrium; Address; Adolescence; Adolescent; Adopted; Adult; Age; Agriculture; Aldosterone; American; Asians; Beverages; Blood Pressure; Calcium; Child; Childhood; Cholesterol; Crossover Design; DASH diet; Dairy Products; Diastolic blood pressure; Diet; Diet Habits; Dietary Fiber; Dietary Intervention; Dietary Practices; Domestic Fowls; Dyslipidemias; Effectiveness; Epidemic; Ethnic group; Excretory function; Fatty acid glycerol esters; Female; Fishes; Food Patterns; Future; Guidelines; Height; High Density Lipoprotein Cholesterol; Hispanics; Hormonal; Hypertension; Intake; Intervention; LDL Cholesterol Lipoproteins; Lead; Leadership; Lipids; Low-Density Lipoproteins; Magnesium; Measures; Meat; Medical; Minerals; Morbidity - disease rate; Nuts; Outcome; Participant; Pattern; Plant Roots; Plasma; Policies; Policy Developments; Potassium; Professional Organizations; Randomized; Randomized Controlled Trials; Recommendation; Reporting; Research; Risk Factors; Sampling; Serum; Shapes; Sodium; Subgroup; Testing; Translations; Triglycerides; blood lipid; blood pressure reduction; calcium excretion; cardiovascular health; community setting; dietary approach; efficacy study; experience; feeding; fruits and vegetables; improved; lipid disorder; prevent; primary outcome; protective effect; public health relevance; racial and ethnic; randomized trial; saturated fat; secondary outcome; sex; sugar; summer research; urinary

 DESCRIPTION (provided by applicant): Antecedents of high blood pressure (BP) and dyslipidemia likely originate in childhood. Furthermore, dietary habits developed during adolescence are carried into adulthood. In order to provide evidence in support of dietary guidelines in children and retard the epidemic of BP and dyslipidemia-related morbidity in later years, we propose a carefully controlled, randomized trial to test, among adolescents, two dietary interventions: (1) the Dietary Approaches to Stop Hypertension (DASH) diet, similar to the USDA food patterns for adolescents recommended by the Dietary Guidelines for Americans, and (2) sodium reduction. To this end, we combined the leadership experience of two research groups, Larry Appel and his team who conducted the DASH studies in adults and Connie Weaver and her team from Purdue who have led multiple controlled feeding studies in adolescents. The proposed study is a randomized, 2x2 factorial isocaloric feeding study with a cross-over design that tests the effects on BP and blood lipids of (1) diet (DASH vs Usual) and (2) sodium intake (High vs Low) in a diverse sample of adolescents. Study participants (n=522: ~50% Female; ~25% White, ~25% Black, ~25% Asian, and ~25% Hispanic) will be 11 to 15 years of age with systolic BP in the upper third of the BP distribution for their sex, age and height. Each participant will receive two of the four interventions, each for 25 days, in random order as part of a summer research camp. BP and lipids will be measured at the end of each feeding period. Results of this trial will provide direct evidence of the impact of the two interventions on both blood pressure and blood lipid levels among adolescents. This information will inform dietary guidance and influence future policy development on strategies to lower blood pressure and improve lipid patterns among adolescents. Most importantly, given that the antecedents to CVD risk factors begin in adolescence and track into adulthood, intervening in adolescence has tremendous potential as a means to prevent CVD in adults.

 描述（由适用提供）：高血压（BP）和血脂异常的先例可能起源于儿童期。此外，在青少年期间养成饮食习惯。为了提供支持儿童饮食指南的证据，并在后来的几年中延迟了BP和血脂异常相关的发病率的流行，我们提出了一项精心控制的，随机的试验，在青少年中进行测试，两种饮食干预措施：（1）饮食中的饮食方法，类似于饮食中的饮食饮食（DASH）饮食饮食饮食饮食，以供饮食饮食饮食饮食，以供usda饮食饮食饮食，以供usda饮食饮食饮食，以供usda饮食饮食饮食，以供usda饮食饮食饮食饮食。 （2）还原钠。为此，我们结合了两个研究小组的领导经验，即拉里·阿佩尔（Larry Appel）和他的团队，他们在成人和康妮·韦弗（Connie Weaver）和她的团队中进行了破折号研究，他们领导了青少年的多项受控喂养研究。拟议的研究是一项随机的2x2阶乘异位喂养研究，其交叉设计测试了对（1）饮食的BP和血脂的影响（1）饮食（dash vs soparual）和（2）在潜水者的青少年样本中的钠（高vs vs Low）。研究参与者（n = 522：〜50％的女性； 〜25％白人，〜25％黑色，〜25％的亚洲人和约25％的西班牙裔）将为11至15岁，其性别，年龄和身高的BP分布的上三分之一。作为夏季研究营的一部分，每个部分都将在四个干预措施中进行25天的两种干预措施。 BP和脂质将在每个进食期结束时测量。该试验的结果将直接证明两种干预措施对青少年血压和血脂水平的影响。该信息将为饮食指导提供信息，并影响未来的政策制定，以降低血压并改善青少年脂质模式的策略。最重要的是，鉴于CVD危险因素的前期开始于青少年，并追踪到成年后，介入青少年具有巨大的潜力，是防止成人CVD的一种手段。