Berries and Bones

浆果和骨头

• 批准号: 9181792
• 负责人: Connie Marie Weaver
• 金额: $ 4.97万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9181792
• 关键词: Age-Related Bone Loss; Aging; Antioxidants; Berry; Blueberries; Bone Marrow; Calcium; Cysteine; Dose; Enzymes; Estrogens; Gene Expression; Gene Targeting; Grant; Human; Kinetics; Knock-out; Lasers; Menopause; Metabolism; Microscopy; Mus; NF-E2-related factor 2; Names; Natural Products; Osteoblasts; Osteoclasts; Osteocytes; Oxidants; Oxidative Stress; Pharmaceutical Preparations; Plant Sources; Postmenopause; Proteins; Rattus; Research; Response Elements; Serum; TNFSF11 gene; Testing; Tracer; Ubiquitination; Vaccinium; Woman; Work; abstracting; bone; bone cell; bone loss; bone turnover; gut microbiota; polyphenol; progenitor; protective effect; rate of change; transcription factor; Age-Related Bone Loss; Aging; Antioxidants; Berry; Blueberries; Bone Marrow; Calcium; Cysteine; Dose; Enzymes; Estrogens; Gene Expression; Gene Targeting; Grant; Human; Kinetics; Knock-out; Lasers; Menopause; Metabolism; Microscopy; Mus; NF-E2-related factor 2; Names; Natural Products; Osteoblasts; Osteoclasts; Osteocytes; Oxidants; Oxidative Stress; Pharmaceutical Preparations; Plant Sources; Postmenopause; Proteins; Rattus; Research; Response Elements; Serum; TNFSF11 gene; Testing; Tracer; Ubiquitination; Vaccinium; Woman; Work; abstracting; bone; bone cell; bone loss; bone turnover; gut microbiota; polyphenol; progenitor; protective effect; rate of change; transcription factor

Grant number: 1 R01 AT008754-01 PI Name: Weaver, Connie M. Modified Project Summary/Abstract Section Polyphenolic-rich plant sources, including berries, reduce age-relate bone loss. Estrogen loss at menopause and during aging leads to accumulation of reactive oxidant species (ROS). Ubiquitinization and degradation of the transcription factor Nrf2 is impeded by oxidative stress allowing Nrf2 to activate antioxidant response elements in target genes to express proteins that detoxify ROS. We will test our hypothesis that bioactive polyphenol metabolites from Vaccinium berries work through this mechanism to reduce bone loss through two specific aims.

赠款编号：1 R01 AT008754-01 PI名称：Weaver，Connie M. 修改的项目摘要/摘要部分 富含多酚的植物来源（包括浆果）减少了年龄相关的骨质流失。更年期和衰老期间的雌激素损失会导致反应性氧化物质（ROS）的积累。转录因子NRF2的泛素化和降解受到氧化应激的阻碍，从而使NRF2激活靶基因中的抗氧化反应元件，以表达排毒ROS的蛋白质。我们将测试我们的假设，即来自离牛摄浆果的生物活性多酚代谢产物通过这种机制起作用，以通过两个特定目标减少骨质流失。