GENE METAL INTERACTIONS AND PARKINSON'S DISEASE

基因金属相互作用与帕金森病

• 批准号: 7379229
• 负责人: Howard Hu
• 金额: $ 4.07万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379229
• 关键词: GENE; METAL; INTERACTIONS; PARKINSON; DISEASE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate 800 PD patients as well as 800 controls matched one to one by age, gender, ethnicity, and geographical region. The two main hypotheses are: (1) Among the cases and controls, higher levels of lead in bone are associated with higher odds of PD case. (2) The effect of bone lead will be highest in individuals with heterozygous or homozygous for HFE gene mutation

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。这项研究将评估 800 名 PD 患者以及 800 名对照者，按年龄、性别、种族和地理区域进行一对一匹配。两个主要假设是：（1）在病例和对照中，骨中铅含量较高与帕金森病发病率较高相关。 (2) 骨铅对HFE基因突变杂合子或纯合子的个体效果最高