Lifestage Exposures and Adult Disease

生命阶段暴露和成人疾病

• 批准号: 8055159
• 负责人: Howard Hu
• 金额: $ 93.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8055159
• 关键词: Lifestage; Exposures; Adult; Disease

The University of Michigan-NIEHS Center is a new entity that will bring together basic and translational scientists into a partnership focused on the theme of "Lifestage Exposures and Adult Disease". The mission is to promote translational research using novel multi-disciplinary approaches to understand the impact of environmental exposures on adult chronic disease through mechanisms involving epigenetic modifications during vulnerable stages of life. This is the culmination of a 2-year planning process of building collaborations (including a major partnership with the CTSA) and functioning as a de-facto preliminary Center. The robust base of research includes projects addressing a variety of environmental toxicants, a large portfolio of cohort studies (and associated biorepositories) spanning the age spectrum, disease-specific research Centers (and associated tissue banks), and basic research on epigenetic mechanisms. In this revised application, the investigators retain their recognized strengths while increasing their focus, decreasing their targeted areas from 6 to 3, each now associated with a Research Team with senior leadership, and decreasing their membership by almost 40%. The investigators' Research Teams will focus on "Epigenetic Regulation", "Oxidative Stress" and "Endocrine Disruptors", subthemes that build off of the Center's strengths. The work starts with an initial emphasis on four diseases well-represented in the investigators' current research portfolio (asthma, prematurity, metabolic syndrome, and neurodegenerative disease), with the flexibility to expand as the Center grows and matures. The Center will sponsor seminars; a Pilot Project Program that capitalizes on major institutional leveraging; outstanding young Center scientists; and outreach and education to the broader scientific and lay community. The research will be facilitated by an Administrative Core and five service cores related to Exposures, Biological Responses, Integrative Health Sciences, Environmental Statistics and Bioinformatics. The Integrated Health Sciences Core will manage a web-based portal providing an innovative interactive kiosk for obtaining critical information on the resources, Core facilities, and tools for research. Core faculty will also provide "translational services", for consulting on the design of translational research and use of their biorepositories and Core facilities. A revised Community Outreach and Education Core will work with the investigators and a Stakeholder Advisory Board to engage in an enhanced range of activities. Administration of the Center will be facilitated by an active Executive Committee and outstanding scientists serving on the External Advisory Committee.

密歇根大学-NIEHS 中心是一个新实体，它将汇集基础科学家和转化科学家，建立伙伴关系，重点关注“生命阶段暴露和成人疾病”这一主题。 其使命是利用新颖的多学科方法促进转化研究，通过涉及生命脆弱阶段表观遗传修饰的机制来了解环境暴露对成人慢性疾病的影响。这是为期 2 年的建立合作（包括与 CTSA 的主要伙伴关系）和作为事实上的初步中心运作的规划过程的顶峰。 强大的研究基础包括针对各种环境毒物的项目、跨越年龄范围的大量队列研究（以及相关的生物样本库）、特定疾病的研究中心（以及相关的组织库）以及表观遗传机制的基础研究。 在这个修订后的申请中，研究人员保留了他们公认的优势，同时增加了关注点，将目标领域从 6 个减少到 3 个，每个领域现在都与一个具有高级领导层的研究团队相关联，并将其成员数量减少了近 40%。 研究人员的研究团队将重点关注“表观遗传调节”、“氧化应激”和“内分泌干扰物”，这些子主题是建立在该中心的优势之上的。这项工作首先重点关注研究人员当前研究组合中代表性的四种疾病（哮喘、早产、代谢综合征和神经退行性疾病），并随着中心的发展和成熟而灵活扩展。该中心将主办研讨会；利用主要机构杠杆作用的试点项目计划；中心优秀青年科学家；以及对更广泛的科学界和非专业界的宣传和教育。 该研究将由一个行政核心和五个与暴露、生物反应、综合健康科学、环境统计和生物信息学相关的服务核心来促进。综合健康科学核心将管理一个基于网络的门户，提供一个创新的交互式信息亭，用于获取有关资源、核心设施和研究工具的关键信息。核心教师还将提供“翻译服务”，为转化研究的设计以及生物样本库和核心设施的使用提供咨询。 修订后的社区外展和教育核心将与调查人员和利益相关者咨询委员会合作，参与范围更广的活动。 活跃的执行委员会和外部咨询委员会的杰出科学家将促进该中心的管理。