A Longitudinal Study of Adopted Youth and Their Families

被收养青少年及其家庭的纵向研究

• 批准号: 8007422
• 负责人: MATTHEW K. MCGUE
• 金额: $ 51.1万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-10 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8007422
• 关键词: Address; Adolescence; Adolescent; Adopted; Adoption; Adult; Affect; Age; Alcohol abuse; Alcohol or Other Drugs use; Antisocial Personality Disorder; Anxiety; Anxiety Disorders; Attention deficit hyperactivity disorder; Behavior; Behavioral; Childhood; Comorbidity; Conduct Disorder; Data; Dependence; Development; Diagnostic and Statistical Manual; Dimensions; Disease; Economics; Environment; Environmental Risk Factor; Etiology; Family; Family Relationship; Family Study; Funding; Genetic; Health; Home environment; Individual; Infant; Inherited; Intake; Intervention; Investigation; Lead; Left; Life; Life Stress; Literature; Longitudinal Studies; Mediating; Mental Depression; Mental Health; Mental disorders; Methods; Nature; Neighborhoods; Outcome; Parents; Pattern; Peer Group; Personality; Play; Positioning Attribute; Preventive; Problem behavior; Progress Reports; Psychopathology; Public Health; Randomized; Research; Risk; Risk Assessment; Risk Marker; Role; Sampling; Sampling Studies; Siblings; Source; Stress; Substance Use Disorder; Substance abuse problem; Telephone Interviews; Testing; Time; Youth; adolescent alcohol; adolescent alcohol abuse; alcohol misuse; anti social; base; cohort; design; emerging adult; follow-up; infancy; innovation; longitudinal design; maternal depression; middle age; neurotoxic; novel; offspring; programs; social; transmission process; underage drinking; young adult

DESCRIPTION (provided by applicant): This application seeks renewal funding for a unique and innovative longitudinal study of adopted and non-adopted families. The Sibling Interaction and Behavior Study (SIBS) includes 409 adopted and 208 non-adopted families. At intake, each family consisted of pair of adolescent siblings and their rearing parents, a total of 2394 individuals. SIBS offspring have completed an intake assessment in mid-adolescence, a first follow-up (FU1) assessment in late-adolescence, and are in the midst of a second follow-up (FU2) assessment in early adulthood. Rate of participation at FU1 and to date in FU2 is well above 90 percent. Intake and FU assessments are extensive and include: 1) comprehensive assessment of common externalizing (e.g., conduct disorder, substance use disorders, ADHD) and internalizing (depression, anxiety disorders) psychopathology; 2) substance use, abuse, and dependence; 3) individual-level markers of risk (personality, academic ability and progress); 4) family relationships (both parent-offspring and sibling); and 5) other environmental risk factors (e.g., peer group, religiousness, life stress, neighborhood). The current application has 4 specific aims, to: 1) complete the FU2 assessment, 2) analyze FU1 and FU2 data to determine the nature of familial risk for common mental disorders; 3) use the principle of Mendelian Randomization to test the effect of adolescent alcohol use and misuse on risk of mental health and substance use disorders in early adulthood; and 4) determine whether individuals adopted in infancy are at heightened risk for mental disorders as young adults. Analysis of SIBS intake data demonstrates that this is a unique study that is making important observations on, for example, the effect of maternal depression, the impact of parent antisocial behavior, the consequences of adolescent alcohol abuse, and the mental health of US adopted youth. Continued support for this program of research will allow us to chart the trajectory of the development of common mental disorders from mid-adolescence through early adulthood, using an adoption design that allows us to identify familial environmental as well as genetic contributions to risk. PUBLIC HEALTH RELEVANCE: The Sibling Interaction and Behavior Study (SIBS) is a longitudinal study of 409 adoptive and 208 non-adoptive families as the offspring in those families have aged from middle-adolescence through late-adolescence to early adulthood. This unique project is determining the environmental consequences of parent psychopathology (e.g., maternal depression), the effect of adolescent alcohol misuse on early-adult mental health problems, and whether individuals adopted as infants have heightened risk for mental health problems as young adults.

描述（由申请人提供）：本申请寻求续签资金，以对被采用和未经装修的家庭进行独特而创新的纵向研究。兄弟姐妹的互动和行为研究（SIBS）包括409和208个未经预料的家庭。在进气口中，每个家庭都由一对青少年兄弟姐妹及其养育父母组成，共有2394个人。 SIBS后代在青春期中期完成了摄入量评估，在青春期后期进行了首次随访（FU1）评估，并且在成年初期的第二次随访（FU2）评估中。 FU1和FU2的参与率远高于90％。摄入量和FU评估是广泛的，包括：1）对共同外部化（例如，行为障碍，药物使用障碍，多动症）的全面评估和内在化（抑郁症，焦虑症）精神病理学； 2）使用物质，滥用和依赖； 3）风险的个人级别标记（人格，学术能力和进步）； 4）家庭关系（父母源和兄弟姐妹）； 5）其他环境风险因素（例如，同伴群体，宗教，生命压力，邻里）。当前的应用具有4个具体目标：1）完成FU2评估，2）分析FU1和FU2数据以确定常见精神疾病的家族风险的性质； 3）使用孟德尔随机化原则来测试青少年饮酒的影响，并滥用成年早期的精神健康和药物使用障碍的风险； 4）确定在婴儿期被收养的个人是否有较小的年轻人的精神障碍风险。对SIB摄入数据的分析表明，这是一项独特的研究，对例如，孕产妇抑郁症的影响，父母反社会行为的影响，青春期酒精滥用的后果以及我们采用青年的心理健康的影响。对这项研究计划的持续支持将使我们能够使用采用设计来绘制从青春期中期到成年初期的常见精神障碍发展的轨迹，该设计使我们能够识别家庭环境以及对风险的遗传贡献。公共卫生相关性：兄弟姐妹的互动和行为研究（SIBS）是一项纵向研究，对409个收养和208个非顾问家庭，因为这些家庭的后代已经从中期青春期到青年后期到成年早期衰老。这个独特的项目是确定父母心理病理学（例如孕产妇抑郁症）的环境后果，青春期滥用的酗酒对早期心理健康问题的影响，以及被接受为婴儿的个人是否增加了对年轻人的心理健康问题的风险。