Adolescent drinking and midlife outcomes: A prospective cotwin control study

青少年饮酒与中年结局：一项前瞻性 cotwin 对照研究

• 批准号: 10388266
• 负责人: MATTHEW K. MCGUE
• 金额: $ 61.35万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-10 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10388266
• 关键词: Achievement; Acute; Address; Adolescence; Adolescent; Adult; Age; Alcohol consumption; Alcohol dependence; Alcoholic beverage heavy drinker; Alcohols; Antisocial Personality Disorder; Characteristics; Data; Data Analyses; Deposition; Development; Disease; Education; Elderly; Environmental Risk Factor; Evaluation; Family Study; Gender; Genetic; Habits; Health behavior; Heavy Drinking; Individual; Instruction; Investigation; Lead; Left; Length; Life; Life Stress; Link; Literature; Long-Term Effects; Longitudinal Studies; Medical; Mental Depression; Mental Health; Methods; Minnesota; Modeling; Neurocognitive; Occupational; Outcome; Patient Self-Report; Pattern; Persons; Prospective Studies; Prospective cohort study; Quality of life; Research; Research Design; Research Personnel; Risk; Risk Factors; Role; Social Functioning; Social isolation; Spouses; Substance abuse problem; Surveys; Testing; Twin Multiple Birth; Twin Studies; Woman; Youth; alcohol poisoning; automobile accident; behavioral disinhibition; binge drinking; cognitive function; cohort; comorbidity; course development; design; drinking; early drinking; emerging adult; experimental study; follow-up; gender difference; high-risk adolescents; innovation; longitudinal design; member; men; middle age; physical conditioning; prospective; psychosocial; public repository; sexual victimization; social; substance use; telomere; underage drinking

ORIGINAL ABSTRACT Adolescence is a period when many individuals begin to experiment with alcohol, with some progressing rapidly to abusive drinking. The acute problems associated with heavy adolescent alcohol use (e.g., alcohol poisoning, sexual victimization, automobile accidents) have been well documented; less certain is whether adolescent alcohol use also has long-term consequences. Three recent reviews of the relevant literature have come to similar conclusions: adolescent drinking is associated with adult functioning, but the existing literature does not tell us whether these associations are causal or whether the consequences of adolescent drinking are long-lasting. We propose to address these limitations with a prospective study of a unique cohort of twins. These twins were initially assessed at age 17, at the early stages of alcohol use, and again at age 20, the period in adolescence when alcohol use peaks. They were subsequently assessed at ages 24 and 29, a period characterized by life-role transition. We now propose to assess them at mid-life (average age of 42 years), a developmental period characterized by stability and for most a moderation of youthful patterns of heavy drinking. The in-person assessment will cover 4 major domains of functioning: 1) mental health, including substance use and abuse, 2) physical health and behavior, 3) neurocognitive function, and 4) psychosocial outcomes including educational and occupational achievement and relationship quality. We estimate that 1130 twins will participate (greater than 90% of the surviving members of the original cohort) in the in-person assessment and that 910 of their spouses/partners will also complete a brief mail survey. Analysis of the data will document the range of adult outcomes associated with adolescent drinking and evaluate three alternative models to account for these effects: 1) the factors that lead to early and heavy drinking in adolescence also increase the likelihood of deficits in adulthood (i.e., confounding), 2) adolescent heavy drinkers tend to become adult heavy drinkers (i.e., drinking persistence), and 3) adolescent drinking upsets the normal course of adult. The innovative cotwin control design, which controls for genetic and shared environmental factors on outcomes, will help isolate possible causal effects of adolescent drinking on midlife functioning. The extensive earlier assessments of this cohort will provide a wealth of information for propensity score D RELEVANCE (See instructions): The project follows a large cohort of twins from age 17 to age 36-44 to identify the consequences of heavy and abusive drinking in adolescence for functioning in mid-life. The project seeks to determine the extent to which adolescent drinking impacts mental health, physical health, cognitive and social functioning in mid-life and the extent to which any effects can be ameliorated by drinking desistence.

原始摘要 青春期是许多人开始尝试酒精的时期 迅速滥用饮酒。与青少年饮酒有关的急性问题（例如 酒精中毒，性受害，汽车事故）已得到充分记录；不确定是 青春期饮酒是否也会产生长期后果。有关相关的三项评论 文献也得出了类似的结论：青少年饮酒与成人功能有关，但是 现有文献没有告诉我们这些关联是因果关系还是后果是 青少年饮酒是长期的。我们建议通过一项前瞻性研究来解决这些限制 独特的双胞胎队列。这些双胞胎最初在17岁时，在酒精的早期进行评估 使用，在20岁时再次使用酒精使用峰值的时期。他们随后 在24岁和29岁时进行评估，以生命角过渡为特征。我们现在建议评估 他们处于中年（平均年龄42岁），这是一个以稳定性为特征的发育期 年轻饮酒的年轻模式。面对面评估将涵盖4个主要领域 功能：1）心理健康，包括药物使用和滥用，2）身体健康和行为，3） 神经认知功能，以及4）社会心理成果，包括教育和职业 成就和关系质量。我们估计有1130个双胞胎将参加（超过90％的双胞胎 在面对面评估中幸存的原始队列成员和他们的910 配偶/合作伙伴还将完成简短的邮件调查。数据分析将记录 与青少年饮酒相关的成人结果，并评估三种替代模型以说明 这些影响：1）导致青春期早期和大量饮酒的因素也增加了 成年后的缺陷（即混淆），2）青少年饮酒者倾向于成年 大量饮酒者（即饮酒持久性）和3）青少年饮酒是成年人正常过程。 创新的Cotwin控制设计，它控制着遗传和共享环境因素 结果将有助于隔离青少年饮酒对中年功能的可能因果关系。这 对该队列的大量早期评估将为倾向得分提供大量信息 d 相关性（请参阅说明）： 该项目遵循从17岁到36-44岁的大批双胞胎队列，以确定 青春期大量虐待饮酒，以在中年运作。该项目旨在确定 青少年饮酒影响心理健康，身体健康，认知和社会的程度 在中期运作以及通过饮酒的抑制作用可以改善任何影响的程度。