Clinical and Basic Studies in Polycystic Ovarian Syndrome

多囊卵巢综合征的临床与基础研究

• 批准号: 8081160
• 负责人: John C Marshall
• 金额: $ 4.7万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8081160
• 关键词: Address; Adolescent; Affect; Age; Androgens; Anovulation; Area; Biological Assay; Clinical; Diabetes Mellitus; Disease; Early identification; Environment; Etiology; Female Adolescents; Funding; Goals; Gonadotropins; Health; Hypothalamic structure; Infertility; Instruction; Insulin; Insulin-Like Growth Factor I; Investigation; Knowledge; Laboratories; Ligands; Link; Metabolic; Metabolic syndrome; Nature; Neurons; Obesity; Ovarian; Ovarian Diseases; Physiologic pulse; Pilot Projects; Pituitary Gland; Process; Progesterone; Puberty; Regulation; Reproduction; Research; Research Personnel; Resistance; Resources; Risk; Role; Scientist; Services; Steroids; Syndrome; Testosterone; Therapeutic; Translational Research; Universities; Virginia; Woman; clinical application; design; effective therapy; girls; planetary Atmosphere; programs; reproductive; response

PROJECT SUMMARY (See instructions): The proposed U54 Center at the University of Virginia will have a major goal of promoting translational research leading to application of new basic findings to clinical application. The Center theme is "Clinical and Basic Studies in Polycystic Ovarian Syndrome (PCOS)". This topic is appropriate to the goals of the Cooperative Centers Program, in that present therapeutic approaches to the anovulation and metabolic abnormalities in the disorder are of limited efficacy, and importantly, the basic mechanisms underlying PCOS remain uncertain. Current hypotheses as to of the etiology of PCOS center around regulation of GnRH secretion and action, and/or disordered ovarian function, either primary in nature or consequent to abnormal stimulation by gonadotropins or co-gonadotropins such as insulin and IGF-1. The U54 Center proposes 1 clinical project, 1 clinical pilot project, and 2 related basic projects to investigate these areas. Project I addresses abnormalities (testosterone induced resistance to progesterone action) in the regulation of the GnRH pulse generator in normal and obese adolescent girls and is directly related to basic studies in Projects II, modulation of GnRH-Gonadotrope responses - steroid-metabolic interactions, and Project III on steroid-metabolic interactions in the control of GnRH neurons. The pilot project is a clinical project addressing factors determining obesity-associated hyperandrogenemia in peripubertal girls. The Center subprojects are supported by two Cores proposed to operate under an "open access" formula. Overall integration of the research will be performed by the Administration Core, and specific laboratory services will be available to U54 projects and to eligible funded RSB program relevant projects through the Ligand Assay and Analysis Core, the latter having been designated a national resource by the RSB. The proposed U54 Center will build on the productive collegia! atmosphere of the existing U54 Center at the University of Virginia and allow clinical and basic investigation of factors in the etiology of a common disorder of women during the reproductive years. The linking of basic and clinical projects will allow rapid transfer of basic information to clinical application, with the overall goal of enhancing our abilities to predict the disorder in adolescents and to enhance therapeutic approaches to PCOS with a resultant improvement in health for some 6-8% of women in the U.S.

项目摘要（参见说明）： 拟建的弗吉尼亚大学 U54 中​​心的主要目标是促进转化研究，从而将新的基础发现应用于临床。中心主题为“多囊卵巢综合症（PCOS）的临床与基础研究”。该主题适合该组织的目标 合作中心计划，目前针对该疾病的无排卵和代谢异常的治疗方法效果有限，而且重要的是，PCOS 的基本机制仍不确定。目前关于 PCOS 病因的假设主要围绕 GnRH 的调节 分泌和作用，和/或卵巢功能紊乱，无论是原发性的还是促性腺激素或辅助促性腺激素（例如胰岛素和 IGF-1）异常刺激的结果。 U54中心提出了1个临床项目、1个临床试点项目和2个相关基础项目来研究这些领域。项目 I 解决正常和肥胖青春期女孩 GnRH 脉冲发生器调节中的异常（睾酮诱导的黄体酮作用抵抗），并与项目 II 的基础研究直接相关，即 GnRH 促性腺激素反应的调节 - 类固醇代谢相互作用，以及项目 III 关于 GnRH 神经元控制中的类固醇代谢相互作用。该试点项目为临床项目 解决青春期前后女孩肥胖相关高雄激素血症的决定因素。 该中心的子项目由两个核心项目支持，提议按照“开放获取”模式运作。 研究的整体整合将由管理核心进行，特定的实验室服务将通过配体测定和分析核心向 U54 项目和符合资格的 RSB 计划相关项目提供，后者已被 RSB 指定为国家资源。 拟议的 U54 中​​心将建立在富有成效的学院之上！弗吉尼亚大学现有 U54 中​​心的氛围，允许对育龄妇女常见疾病的病因学因素进行临床和基础研究。基础项目和临床项目的结合将使基础信息能够快速转移到临床应用，总体目标是提高我们预测青少年疾病的能力，并加强 PCOS 的治疗方法，从而改善 6-8 岁左右的健康状况美国女性所占百分比