PROGESTERONE INHIBITION OF GNRH PULSATILITY IN ADOLESCENT GIRLS

黄体酮对青春期女孩 GNRH 搏动的抑制作用

• 批准号: 8167209
• 负责人: John C Marshall
• 金额: $ 1.47万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167209
• 关键词: Adolescent; Adult; Computer Retrieval of Information on Scientific Projects Database; Female Adolescents; Funding; Grant; Institution; Lead; Polycystic Ovary Syndrome; Progesterone; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Woman

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescent hyperandrogenemia appears to be a precursor to adult polycystic ovary syndrome (PCOS). We have found that adult women with PCOS have a reduced sensitivity to progesterone inhibition of GnRH pulsatility. We propose to examine progesterone inhibition of GnRH pulsatility in normal and hyperandrogenemic adolescent girls to determine whether this may be an underlying cause of hyperandrogenemia, and eventually, PCOS. The results will help us understand the causes of PCOS and may lead to preventative treatment.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 青少年高雄激素血症似乎是成人多囊卵巢综合征（PCOS）的先兆。我们发现，患有 PCOS 的成年女性对黄体酮抑制 GnRH 搏动的敏感性降低。我们建议在正常和高雄激素血症少女中检查黄体酮对 GnRH 搏动的抑制，以确定这是否可能是高雄激素血症以及最终导致 PCOS 的根本原因。结果将帮助我们了解多囊卵巢综合症的原因，并可能导致预防性治疗。