Dietary supplement use, physical activity, body mass index, and pancreatic cancer

膳食补充剂的使用、体力活动、体重指数和胰腺癌

• 批准号: 8055989
• 负责人: Ka Kahe
• 金额: $ 7.18万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8055989
• 关键词: 18 year old; Address; Adult; Affect; Age; American; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Area; Ascorbic Acid; Behavioral; Benefits and Risks; Beta Carotene; Body Weight; Body mass index; Botanicals; Cancer Etiology; Cancer Prognosis; Carotene; Catchment Area; Cessation of life; Cohort Studies; Country; County; Data; Data Analyses; Development; Diagnosis; Diet; Dietary Component; Disease; Environmental Exposure; Epidemiologic Studies; Folate; Funding; Ginkgo biloba; Goals; Health; High Prevalence; Incidence; Individual; Inflammation; Intake; Investigation; Iron; Knowledge; Life; Life Style; Link; Malignant Neoplasms; Malignant neoplasm of pancreas; Measures; Methods; Minerals; Multivitamin; National Cancer Institute; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Obesity; Omega-3 Fatty Acids; Out-Migrations; Oxidative Stress; Participant; Pharmaceutical Preparations; Physical activity; Pilot Projects; Prevention; Property; Public Health; Questionnaires; Recording of previous events; Recruitment Activity; Registries; Relative (related person); Resources; Risk; Risk Factors; Role; Selenium; Staging; Survival Rate; System; Time; United States; Variant; Vitamin E; Vitamins; Washington; Woman; aged; anticancer research; base; cancer risk; case control; chronic pancreatitis; cigarette smoking; cohort; conventional therapy; dietary supplements; dosage; energy balance; epidemiologic data; follow-up; interest; lycopene; member; men; modifiable risk; neoplasm registry; outcome forecast; prevent; protective effect; 18 year old; Address; Adult; Affect; Age; American; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Area; Ascorbic Acid; Behavioral; Benefits and Risks; Beta Carotene; Body Weight; Body mass index; Botanicals; Cancer Etiology; Cancer Prognosis; Carotene; Catchment Area; Cessation of life; Cohort Studies; Country; County; Data; Data Analyses; Development; Diagnosis; Diet; Dietary Component; Disease; Environmental Exposure; Epidemiologic Studies; Folate; Funding; Ginkgo biloba; Goals; Health; High Prevalence; Incidence; Individual; Inflammation; Intake; Investigation; Iron; Knowledge; Life; Life Style; Link; Malignant Neoplasms; Malignant neoplasm of pancreas; Measures; Methods; Minerals; Multivitamin; National Cancer Institute; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Obesity; Omega-3 Fatty Acids; Out-Migrations; Oxidative Stress; Participant; Pharmaceutical Preparations; Physical activity; Pilot Projects; Prevention; Property; Public Health; Questionnaires; Recording of previous events; Recruitment Activity; Registries; Relative (related person); Resources; Risk; Risk Factors; Role; Selenium; Staging; Survival Rate; System; Time; United States; Variant; Vitamin E; Vitamins; Washington; Woman; aged; anticancer research; base; cancer risk; case control; chronic pancreatitis; cigarette smoking; cohort; conventional therapy; dietary supplements; dosage; energy balance; epidemiologic data; follow-up; interest; lycopene; member; men; modifiable risk; neoplasm registry; outcome forecast; prevent; protective effect

DESCRIPTION (provided by applicant): Pancreatic cancer is the fourth most common cause of cancer deaths in the United States (U.S.), has a very poor prognosis, and is generally unresponsive to conventional therapies. Therefore, it is critical to identify modifiable factors that can be used in prevention efforts to reduce risk for developing this disease. Diet, physical activity, and obesity have been postulated to potentially influence pancreatic cancer risk, but results are inconsistent. Also, millions of Americans use dietary (vitamin, mineral, and herbal) supplements to prevent cancer and other diseases, but with few exceptions, there is sparse evidence for either their benefits or risks. Specific Aims The goal of this study is to examine associations of various dietary supplements with pancreatic cancer incidence, using previously collected data from a large cohort study with a high proportion of supplement users. The primary specific aims are to investigate associations of supplemental intakes of nutrients with anti-inflammatory (vitamin E, selenium, and omega-3 fatty acids) and antioxidant properties (vitamin C, vitamin E, beta-carotene, lycopene, and selenium) over the 10-year period ending at baseline with the incidence of pancreatic cancer. Secondary aims are to examine associations of intakes of specific, less common vitamin, mineral, botanical, and other supplements (e.g., folate, iron, gingko biloba) and non- steroidal anti-inflammatory drugs (NSAIDs); as well as physical activity and body mass index levels at baseline and ages 18, 30, and 45 years with pancreatic cancer incidence. Methods Between 2000-2002, 77,738 men and women, aged 50-76 from western Washington State completed a baseline questionnaire that captured detailed information on use of 38 supplements over the previous 10 years, diet, physical activity (using a validated questionnaire), anthropometrics, health history, and cancer risk factors. Supplement users were targeted in recruitment; therefore, supplement use by cohort members is both high and of long duration: 79% were ever users of a supplement, and 66% used multivitamins,46% used individual vitamin C, and 47% used individual vitamin E, typically for 5-8 of the previous 10years. The cohort is being followed for pancreatic cancers by linkage to the western Washington SEER cancer registry, deaths by linkage to the Washington State death file, and out-migration from the SEER catchment area by linkage to the National Change of Address system. This proposal seeks funds to conduct analyses addressing the specific aims. We expect to identify 215 pancreatic cancer cases after a mean follow-up of 8.3 years. The primary exposure would be average intake per day over the previous 10 years of the nutrient of interest (single supplements plus multivitamins), and all analyses will be adjusted for diet and other potential confounders and effect modifiers. Significance The results of this study will be one of the first to examine associations of dietary supplement use, as well as physical activity and obesity, with risk for pancreatic cancer, a disease with a high fatality rate and few known modifiable risk factors. We would use data from the only cohort study specifically focused on the etiologic relationships of dietary supplements with cancer risk which carefully measured supplement use and confounding factors. Importantly, given the high prevalence of dietary supplement use in the U.S., our findings will have important public health implications regardless of whether we find protective effects, increased risks, or no effects of supplements on pancreatic cancer risk.

描述（由申请人提供）：胰腺癌是美国癌症死亡（美国）的第四大最常见原因，预后较差，通常对常规疗法没有反应。因此，至关重要的是要识别可修改的因素，这些因素可用于预防措施降低这种疾病的风险。饮食，体育锻炼和肥胖症已被假定可能影响胰腺癌的风险，但结果不一致。此外，数以百万计的美国人使用饮食（维生素，矿物质和草药）来预防癌症和其他疾病，但除了少数例外，其益处或风险的证据很少。具体目的是本研究的目的是使用先前从一项大型队列研究中收集的数据，研究各种饮食补充剂与胰腺癌发病率的关联。主要的具体目的是研究养分的补充摄入量与抗炎（维生素E，硒和omega-3脂肪酸）和抗氧化特性（维生素C，维生素E，BITA-可胡萝卜素E，BITA，番茄红素，番茄红素和Selenium）的相关性，该癌症是在10年的基准期间与cancer cancer Instrient cancer cancer cancer cancer cancer cance cancr cance cancrient cancr cancr cancr cancr cancrient cancrient cancrient carcived is c is拿家保持带过。次要目的是检查特异性，较不常见的维生素，矿物质，植物和其他补充剂（例如叶酸，铁，金黄色biloba）和非类固醇抗炎药（NSAIDS）的摄入量；以及胰腺癌发病率的基线和45岁年龄和45年的体育活动和体重指数水平。 2000 - 2002年2000 - 738名男女之间的方法从西华盛顿州（Western Washington State）50-76岁完成了一份基线问卷，该问卷捕获了有关在过去10年中使用38种补充剂的详细信息，饮食，体育活动（使用验证的调查表），人类学，健康病史，健康病史和癌症风险因素。补充用户是针对招聘的；因此，队列成员的补充使用持续时间很高，持续时间很长：有79％是补充剂的使用者，而66％的使用多种维生素，46％的使用单个维生素C，而47％的人使用了单个维生素E，通常用于前10年的5-8个。通过与西华盛顿先知癌症注册中心联系，与华盛顿州死亡档案的死亡，以及通过与全国性地址系统变更联系，通过与华盛顿州死亡档案的死亡进行了连接，与西华盛顿州死亡档案的死亡以及来自Seer集水区的迁移，正在遵循胰腺癌的同伴。该提案寻求资金来进行针对特定目标的分析。我们预计在平均随访为8。3年后，将确定215例胰腺癌病例。主要的接触是在感兴趣的养分（单一补充剂以及多种维生素）的前10年中每天的平均摄入量，并且所有分析都将针对饮食和其他潜在的混杂因素进行调整，并进行了效果修饰符。意义这项研究的结果将是最早研究饮食补充剂使用以及体育锻炼和肥胖的关联的结果之一，以及患有胰腺癌的风险，一种死亡率较高的疾病，几乎没有已知的可修改风险因素。我们将使用唯一的同类研究中的数据，专门针对饮食补充剂具有癌症风险的病因关系，这些补充剂仔细测量了补充使用和混杂因素。重要的是，鉴于美国饮食补充剂使用的高度流行，我们的发现将具有重要的公共卫生影响，无论我们是否发现保护作用，风险增加或补充剂对胰腺癌风险的影响没有影响。