Serum fatty acids and ischemic stroke in women

女性血清脂肪酸与缺血性中风

• 批准号: 7470251
• 负责人: Ka Kahe
• 金额: $ 26.33万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470251
• 关键词: Acids; Animals; Arachidonic Acids; Arteries; Arteriosclerosis; Atherosclerosis; Biological; Biological Markers; Blood Pressure; Blood specimen; Clinical; Coronary heart disease; Data; Databases; Development; Dietary Fats; Eicosapentaenoic Acid; Epidemiologic Studies; Etiology; Fatty Acids; Fatty acid glycerol esters; Funding; Goals; Infarction; Intake; Ischemic Stroke; Knowledge; Life Style; Linoleic Acids; Linolenic Acids; Lipoproteins; Measurement; Myristic Acids; Nested Case-Control Study; Nutrient; Observational Study; Omega-3 Fatty Acids; Omega-6 Fatty Acids; Palmitic Acids; Pathogenesis; Patient Self-Report; Pattern; Play; Postmenopause; Public Health; Rate; Risk; Risk Factors; Role; Saturated Fatty Acids; Serum; Stroke; Testing; Trans Fatty Acids; Vascular Diseases; Woman; Women' s Health; blood lipid; case control; cerebral artery; disorder risk; elaidic acid; prospective; tool; Acids; Animals; Arachidonic Acids; Arteries; Arteriosclerosis; Atherosclerosis; Biological; Biological Markers; Blood Pressure; Blood specimen; Clinical; Coronary heart disease; Data; Databases; Development; Dietary Fats; Eicosapentaenoic Acid; Epidemiologic Studies; Etiology; Fatty Acids; Fatty acid glycerol esters; Funding; Goals; Infarction; Intake; Ischemic Stroke; Knowledge; Life Style; Linoleic Acids; Linolenic Acids; Lipoproteins; Measurement; Myristic Acids; Nested Case-Control Study; Nutrient; Observational Study; Omega-3 Fatty Acids; Omega-6 Fatty Acids; Palmitic Acids; Pathogenesis; Patient Self-Report; Pattern; Play; Postmenopause; Public Health; Rate; Risk; Risk Factors; Role; Saturated Fatty Acids; Serum; Stroke; Testing; Trans Fatty Acids; Vascular Diseases; Woman; Women' s Health; blood lipid; case control; cerebral artery; disorder risk; elaidic acid; prospective; tool

DESCRIPTION (provided by applicant): While coronary heart disease (CHD) and ischemic stroke share some major risk factors, limited epidemiological data on dietary fats and vascular disease risk indicate that fatty acids have different associations with ischemic stroke than with CHD. The established associations between types of fat and CHD do not appear to apply to ischemic stroke. One explanatory hypothesis for the paradoxical observations is that arteriosclerosis in different types of cerebral arteries has different causal patterns. Particularly, atherosclerosis may only be involved in large artery infarction, and other risk factors such as blood pressure may play more important role in stroke development However, data on the associations of fatty acids and ischemic stroke and its subtypes including lacunar (small artery), atherosclerotic (large artery) and cardioembolic infarction are lacking. The general goal of this study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women. A prospective nested case-control study of 971 ischemic stroke cases and 971 matched controls in the Women's Health Initiative (WHI) Observational Study is proposed to achieve the objectives. Two major endeavors are planned for the proposed project: 1) assess serum fatty acids composition with previously collected and stored blood specimens; and 2) perform the statistical analyses, which undertake the specific aims and hypothesis. The proposed study will fill the gap in knowledge regarding associations of fatty acids and subtypes of ischemic stroke. Findings from this project will potentially help identify people at high risk of ischemic stroke as well as clarify possible differences between fatty acids and risk of ischemic stroke versus risk of CHD. The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes. PUBLIC HEALTH RELEVANCE: The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes.

描述（由申请人提供）：而冠状动脉疾病（CHD）和缺血性中风具有一些主要危险因素，关于饮食脂肪和血管疾病风险的流行病学数据有限，表明脂肪酸与缺血性中风的关联与与CHD的关联不同。脂肪类型和冠心病之间的已建立关联似乎不适用于缺血性中风。悖论观察的一种解释性假设是，不同类型的脑动脉的动脉硬化具有不同的因果模式。特别是，动脉粥样硬化可能仅参与大动脉梗塞，而其他危险因素（例如血压）可能在中风发育中起更重要的作用，但是，缺乏有关脂肪酸和缺血性中风的关联及其亚型（包括lace骨（小动脉），动脉粥样硬化（大动脉）和卡无动脉）和肉毒杆菌梗死的数据。这项研究的一般目标是检查精华脂肪酸与缺血性中风的风险及其在绝经后妇女中的亚型之间的关联。提出了一项针对妇女健康计划（WHI）观察性研究中971例缺血性中风病例和971个匹配对照的前瞻性嵌套病例对照研究，以实现目标。计划针对拟议项目进行了两个主要的努力：1）评估先前收集和储存的血样的血清脂肪酸组成； 2）执行统计分析，该分析进行了具体的目的和假设。拟议的研究将填补有关脂肪酸和缺血性中风亚型关联的知识的空白。该项目的发现可能有助于确定有缺血性中风的高风险的人，并澄清脂肪酸与缺血性中风风险与冠心病风险之间的可能差异。拟议的研究是检查血清脂肪酸与缺血性中风的风险及其亚型之间的关联，而在绝经后妇女中，中风风险增加。这是调查绝经后妇女中风风险的及时且经济的方法。这项研究产生的数据应提供有关缺血性中风的病因和数据的新信息，以探索饮食原因的新探索。公共卫生相关性：拟议的研究是检查血清脂肪酸与缺血性中风的风险及其在中风风险增加的绝经后妇女中的相关性。这是调查绝经后妇女中风风险的及时且经济的方法。这项研究产生的数据应提供有关缺血性中风的病因和数据的新信息，以探索饮食原因的新探索。