A multichannel vector biomagnetometer to characterize gastrointestinal slow waves

表征胃肠慢波的多通道矢量生物磁力计

• 批准号: 7794058
• 负责人: LEONARD A BRADSHAW
• 金额: $ 34.2万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-04 至 2012-03-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794058
• 关键词: Detection; Devices; Disease; Exhibits; Intestines; Magnetism; Modeling; Relative (related person); Resolution; Small Intestines; Source; Stomach; Variant; fetal; gastrointestinal; improved; instrument; instrumentation; interest; noninvasive diagnosis; sensor; spatiotemporal; success; superconducting quantum interference device; vector

DESCRIPTION (provided by applicant): We propose an upgrade to our existing Superconducting QUantum Interference Device (SQUID) biomagnetometer (Tristan Model 637i) that will allow us (1) to increase the spatial resolution by installing additional channels; and (2) to add additional magnetic vector sensors in the center of the recording array. The upgraded instrument will have a greater ability to detect underlying bioelectrical activity with higher spatial resolution, to discriminate multiple sources of bioelectric activity and to identify subtle spatiotemporal variations in bioelectrical activity. The biomagnetic detection of gastrointestinal electrical activity offers the possibility of noninvasive diagnosis and characterization of disease states. The primary application of the upgraded device will be the detection of gastric and intestinal slow waves. In gastric studies in Project 1, the current instrumentation provides for the determination of an average propagation velocity, whereas the gastric propagation velocity exhibits a known spatial gradient. The increased spatial resolution of the modified instrument will allow us to compute the propagation velocity in different gastric regions. The detection of intestinal slow waves requires higher spatial resolution owing to (1) the relative size of the source compared with the gastric slow wave and (2) the presence of multiple adjacent small bowel segments in the vicinity of the segment of interest. The increased spatial resolution along with the new vector sensors will better enable us to distinguish these multiple sources, critical to the success of Project 2. Additionally, increased spatial resolution will improve our modeling abilities in Project 3. Finally, we will use the upgraded device to study the fetal magnetocardiogram.

描述（由申请人提供）：我们建议对现有的超导量子干扰装置（Squid）生物磁性计（Tristan Model 637i）进行升级，以使我们（1）通过安装其他通道来增加空间分辨率； （2）在记录阵列的中心添加其他磁性矢量传感器。升级的仪器将具有更大的能力，可以检测具有较高空间分辨率的基本生物电活动，以区分多种生物电活动来源并确定生物电活动中的细微时空变异。胃肠道电活动的生物磁检测提供了疾病状态无创诊断和表征的可能性。升级设备的主要应用将是检测胃和肠慢波。在项目1的胃研究中，当前的仪器提供了平均传播速度的确定，而胃繁殖速度则表现出已知的空间梯度。修改仪器的空间分辨率增加将使我们能够计算不同胃区域的传播速度。由于（1）与胃慢波相比，肠道慢波的检测需要更高的空间分辨率，并且（2）在感兴趣段附近存在多个相邻的小肠段。增加的空间分辨率以及新的向量传感器将更好地使我们能够区分这些多个来源，这对于项目2的成功至关重要。此外，增加的空间分辨率将提高项目3中的建模能力。最后，我们将使用升级的设备。研究胎儿心动图。