BIOMAGNETIC CHARACTERIZATION OF GASTRIC DYSRHYTHMIAS

胃节律失常的生物磁学特征

基本信息

批准号：
7375579
负责人：
LEONARD A BRADSHAW
金额：
$ 0.08万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-12-01 至 2006-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7375579
关键词：
BIOMAGNETIC CHARACTERIZATION GASTRIC DYSRHYTHMIAS

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS(ES): 1) Gastric electrical activity (GEA) propagates in the smooth muscle syncytium of the stomach in regular spatiotemporal patterns. 2) Internal gastric electrical patterns in normal tissue produce regular external gastric magnetic field patterns. 3) Gastric electrical patterns in normal humans produce regular spatiotemporal patterns in multichannel external magnetic field recordings. 4) Gastric dysrhythmias resulting from mechanical uncoupling of the gastric syncytium produce irregular spatiotemporal patterns in recordings of both internal serosal potentials and external magnetic fields. 5) Autonomic disorders known to cause gastric dysrhythmias result in abnormal gastric magnetic field spatiotemporal patterns. 6) Patients w/diabetic gastroparesis exhibit abonormal postprandial gastric magnetic field patterns compared to normal volunteers. SPECIFIC AIMS: 1) Characterize magnetic patterns of GEA in normal human volunteers. 2) Characterize the effect of autonomic disorders on gastric magnetic field patterns. 3) Characterize the magnetic signature of diabetic gastroparesis.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。假设（ES）：1）胃电活动（GEA）以常规时空模式在胃的平滑肌合成中传播。 2）正常组织中的内部胃电气模式会产生常规的外部胃磁场模式。 3）正常人中的胃电气模式在多通道外部磁场记录中产生常规时空图案。 4）由胃合胞菌的机械解偶联引起的胃异常，在内部浆膜电位和外部磁场的记录中产生不规则的时空模式。 5）已知会导致胃异常的自主疾病导致异常的胃磁场时空模式。 6）与正常志愿者相比，患有糖尿病性胃轻瘫的患者表现出餐后胃磁场的异常状态。具体目的：1）表征正常人类志愿者中GEA的磁性模式。 2）表征自主疾病对胃磁场模式的影响。 3）表征糖尿病性胃轻瘫的磁性特征。