BIOMAGNETIC CHARACTERIZATION OF GASTRIC DYSRHYTHMIAS

胃节律失常的生物磁学特征

• 批准号: 6856958
• 负责人: LEONARD A BRADSHAW
• 金额: $ 4.99万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6856958
• 关键词: biomagnetism; biomagnetism measurement; clinical research; diabetes mellitus; diagnosis design /evaluation; electrical measurement; electrophysiology; human subject; laboratory rabbit; magnetic field; noninvasive diagnosis; paralysis; stomach; stomach motility /pressure

DESCRIPTION (Verbatim from Applicant's Abstract): In normal subjects, the gastric electrical activity (GEA) consists of a 3 cycle-per-minute slow wave known as the , electrical control activity (ECA). While cutaneous electrodes placed on the surface of the abdomen can record GEA, determination of frequency is the only reliable parameter available from the cutaneous electrogastrogram (EGG). The magnetogastrogram (MGG), the measurement of magnetic fields from GEA, may have greater clinical value than the EGG since gastric magnetic fields reflect the smooth muscle ECA more accurately than the EGG. Low-conductivity tissue layers present in the abdomen serve to smooth and attenuate the electric potential from GEA sources, resulting in a cutaneous EGG that is a spatial summation of many different bioelectric sources. The purpose of this project is to characterize normal and abnormal gastric electrical activity by noninvasive examination of the externally-recorded MGG. We hypothesize that GEA produces regular| spatiotemporal magnetic field patterns that characterize the health status of gastric smooth muscle. Whereas healthy gastric smooth muscle is electrically coupled and allows GEA to propagate from the antral pacemaker site toward the pylorus, we hypothesize that disorders that uncouple gastric smooth muscle disrupt the regular GEA propagation patterns. We hypothesize that spatiotemporal patterns in multi-channel MGG recordings will correlate strongly with the underlying GEA and that they will change under abnormal conditions, reflecting the underlying GEA. We will measure normal serosal potentials and magnetic fields and compare these with data from (1) the mechanically divided stomach, (2) GEA released from autonomic vagal influence, (3) pharmacologically-induced gastric dysrhythmias, and (4) patients with diabetic gastroparesis. If successful, our studies will represent the first characterization of biomagnetic signatures of abnormal gastric function. In addition to improving our understanding of the basic science of gastric electrophysiology, these studies will significantly advance our goal to introduce this method as a routine clinical tool, providing physicians with a noninvasive assessment of the function of the stomach.

描述（逐字摘自申请人摘要）：在正常受试者中， 胃电活动 (GEA) 由每分钟 3 个周期的慢波组成 称为电气控制活动 (ECA)。当皮肤电极 放置于腹部表面可记录GEA、测定频率 是皮肤胃电图唯一可用的可靠参数 （蛋）。胃磁图 (MGG)，测量磁场 由于胃磁场，GEA 可能比 EGG 具有更大的临床价值 比 EGG 更准确地反映平滑肌 ECA。低电导率 腹部的组织层有助于平滑和减弱电 来自 GEA 来源的潜力，产生的皮肤 EGG 是一个空间 许多不同生物电源的总和。该项目的目的是 通过无创性表征正常和异常胃电活动 检查外部记录的 MGG。我们假设 GEA 生产 常规|表征健康的时空磁场模式 胃平滑肌的状态。而健康的胃平滑肌是 电耦合并允许 GEA 从胃窦起搏器位置传播 朝向幽门，我们假设，导致胃平滑肌分离的疾病 肌肉破坏了常规的 GEA 传播模式。我们假设 多通道 MGG 记录中的时空模式将密切相关 与底层 GEA 相关，并且它们会在异常情况下发生变化， 反映基础 GEA。我们将测量正常的浆膜电位并 磁场并将其与来自 (1) 机械划分的数据进行比较 胃，(2) GEA 从自主迷走神经影响中释放出来，(3) 药物引起的胃节律失常，以及（4）糖尿病患者 胃轻瘫。如果成功的话，我们的研究将成为第一个 胃功能异常的生物磁特征的表征。在 除了提高我们对胃的基础科学的了解 电生理学，这些研究将显着推进我们的目标 将该方法作为常规临床工具引入，为医生提供了 对胃功能进行无创评估。