BIOMAGNETIC CHARACTERIZATION OF GASTRIC DYSRHYTHMIAS

胃节律失常的生物磁学特征

• 批准号: 6856958
• 负责人: LEONARD A BRADSHAW
• 金额: $ 4.99万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6856958
• 关键词: biomagnetism; biomagnetism measurement; clinical research; diabetes mellitus; diagnosis design /evaluation; electrical measurement; electrophysiology; human subject; laboratory rabbit; magnetic field; noninvasive diagnosis; paralysis; stomach; stomach motility /pressure; biomagnetism; biomagnetism measurement; clinical research; diabetes mellitus; diagnosis design /evaluation; electrical measurement; electrophysiology; human subject; laboratory rabbit; magnetic field; noninvasive diagnosis; paralysis; stomach; stomach motility /pressure

DESCRIPTION (Verbatim from Applicant's Abstract): In normal subjects, the gastric electrical activity (GEA) consists of a 3 cycle-per-minute slow wave known as the , electrical control activity (ECA). While cutaneous electrodes placed on the surface of the abdomen can record GEA, determination of frequency is the only reliable parameter available from the cutaneous electrogastrogram (EGG). The magnetogastrogram (MGG), the measurement of magnetic fields from GEA, may have greater clinical value than the EGG since gastric magnetic fields reflect the smooth muscle ECA more accurately than the EGG. Low-conductivity tissue layers present in the abdomen serve to smooth and attenuate the electric potential from GEA sources, resulting in a cutaneous EGG that is a spatial summation of many different bioelectric sources. The purpose of this project is to characterize normal and abnormal gastric electrical activity by noninvasive examination of the externally-recorded MGG. We hypothesize that GEA produces regular| spatiotemporal magnetic field patterns that characterize the health status of gastric smooth muscle. Whereas healthy gastric smooth muscle is electrically coupled and allows GEA to propagate from the antral pacemaker site toward the pylorus, we hypothesize that disorders that uncouple gastric smooth muscle disrupt the regular GEA propagation patterns. We hypothesize that spatiotemporal patterns in multi-channel MGG recordings will correlate strongly with the underlying GEA and that they will change under abnormal conditions, reflecting the underlying GEA. We will measure normal serosal potentials and magnetic fields and compare these with data from (1) the mechanically divided stomach, (2) GEA released from autonomic vagal influence, (3) pharmacologically-induced gastric dysrhythmias, and (4) patients with diabetic gastroparesis. If successful, our studies will represent the first characterization of biomagnetic signatures of abnormal gastric function. In addition to improving our understanding of the basic science of gastric electrophysiology, these studies will significantly advance our goal to introduce this method as a routine clinical tool, providing physicians with a noninvasive assessment of the function of the stomach.

描述（逐字研究申请人的摘要）：在普通受试者中， 胃电活动（GEA）由每分钟3周期的慢波组成 称为电控制活性（ECA）。同时皮肤电极 放置在腹部表面可以记录GEA，确定频率 是唯一可从皮肤电及术可用的可靠参数 （蛋）。磁术（MGG），测量磁场 GEA，可能比卵子具有更大的临床价值，因为胃磁场 比鸡蛋更准确地反映平滑肌ECA。低导率 腹部存在的组织层可使电平滑和衰减 GEA来源的潜力，导致皮肤卵是空间的 总结许多不同的生物电源。这个项目的目的是 表征非侵入性的正常和异常胃电活动 检查外部录制的MGG。我们假设GEA产生 常规|特征健康的时空磁场模式 胃平滑肌的状态。健康的胃平滑肌是 电耦合，并允许GEA从Antral Pacemaker站点传播 朝着幽门 肌肉破坏常规的GEA繁殖模式。我们假设这一点 多通道MGG录音中的时空模式将密切相关 借助基础GEA，它们将在异常条件下改变， 反映基础的GEA。我们将衡量正常的浆膜电位，并且 磁场并将其与（1）机械划分的数据进行比较 胃，（2）GEA从自主神经影响中释放出来，（3） 药理学诱导的胃动性障碍和（4）糖尿病患者 胃轻瘫。如果成功，我们的研究将代表第一个 异常胃功能的生物磁信号的表征。在 除了提高我们对胃基础科学的理解 电生理学，这些研究将大大提高我们的目标 将此方法作为常规临床工具介绍，为医生提供 对胃功能的无创评估。