Low-Dose MRI-Compatible Molecular Breast Imaging Device

低剂量 MRI 兼容分子乳腺成像设备

基本信息

批准号：
7800343
负责人：
Irving Weinberg
金额：
$ 38.59万
依托单位：
WEINBERG MEDICAL PHYSICS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7800343
关键词：
Address Agreement Anxiety Architecture Area Back Benchmarking Biopsy Breast Breast Cancer Detection Cancer Patient Characteristics Clinical Clinical Research Clinical Trials Data Detection Deterioration Devices Digital Mammography Dose Economics Excision FDA approved Funding Gamma Rays Goals Health Benefit High Risk Woman Human Human Resources Image Imaging Device Imaging technology Invasive Lesion Letters Life Magnetic Resonance Imaging Malignant Neoplasms Marketing Modeling Molecular Patients Performance Phase Physiologic pulse Positron-Emission Tomography Prevention Price Process Production Publications Publishing Radiation Regulatory Affairs Research Institute Research Personnel Resolution Resources Running Sales Screening procedure Services Site Small Business Innovation Research Grant Suggestion System Technology Testing Time United States National Institutes of Health Update Vendor Women&apos s Health Work base cancer prevention clinical research site cost data acquisition design detector diagnostic accuracy experience high risk improved innovation instrument interest malignant breast neoplasm nanosecond novel patient registry phantom model prototype public health relevance radiotracer simulation success tumor volunteer

项目摘要

DESCRIPTION (provided by applicant): Molecular breast imaging with tumor-seeking radiotracers has been shown to be highly accurate in the detection of breast cancer, particularly for pre-invasive lesion. Removal of pre-invasive lesions represents an ideal target for invasive cancer prevention. In order to conduct cancer prevention studies, we must significantly reduce the radiation dose associated with molecular breast imaging and implement MRI compatibility, without sacrificing spatial and energy resolution. MRI compatibility with co-registration would likely increase sensitivity for detecting small invasive cancers and improve overall diagnostic accuracy. PUBLIC HEALTH RELEVANCE: Use of our proposed system will yield economic benefits that result from detection (and treatment) of pre-invasive breast cancers, so as to avoid the more expensive treatment of patients with potentially metastatic invasive breast cancer. Prevention of invasive breast cancer is expected to prolong life and reduce anxiety for a large number of high-risk women.

描述（由申请人提供）：使用肿瘤追踪放射性示踪剂的分子乳腺成像已被证明在乳腺癌检测中高度准确，特别是对于浸润前病变。去除浸润前病变是预防浸润性癌症的理想目标。为了进行癌症预防研究，我们必须在不牺牲空间和能量分辨率的情况下，显着降低与分子乳腺成像相关的辐射剂量并实现 MRI 兼容性。 MRI 与联合配准的兼容性可能会提高检测小型浸润性癌症的灵敏度并提高整体诊断准确性。公共健康相关性：使用我们提出的系统将产生因浸润前乳腺癌的检测（和治疗）而产生的经济效益，从而避免对潜在转移性浸润性乳腺癌患者进行更昂贵的治疗。预防浸润性乳腺癌有望延长大量高危女性的生命并减少焦虑。