Low-Dose MRI-Compatible Molecular Breast Imaging Device

低剂量 MRI 兼容分子乳腺成像设备

• 批准号: 8669785
• 负责人: Irving Weinberg
• 金额: $ 76.74万
• 依托单位: WEINBERG MEDICAL PHYSICS, LLC
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8669785
• 关键词: Address; American Cancer Society; Anatomy; Appearance; Biochemical; Biomedical Engineering; Breast; Breast Cancer Detection; Cancer Detection; Cancer Patient; Caring; Clinical; Clinical Trials; Community Clinical Oncology Program; Development; Devices; Dose; Duct (organ) structure; Early Diagnosis; Educational process of instructing; Goals; High Risk Woman; Housing; Human; Image; Imaging Device; Individual; Lead; Magnetic Resonance Imaging; Malignant Neoplasms; Mammography; Marketing; Modality; Molecular; Morphologic artifacts; PET/CT scan; Patients; Pharmaceutical Preparations; Phase; Positron; Positron-Emission Tomography; Predictive Value; Prevention therapy; Price; Publishing; Reporting; Resolution; Sales; Silicon; Site; Small Business Innovation Research Grant; Specificity; System; Testing; United States National Institutes of Health; Unnecessary Procedures; Woman; Work; cancer prevention; commercialization; design and construction; diagnostic accuracy; improved; innovation; lifetime risk; malignant breast neoplasm; molecular imaging; photomultiplier; public health relevance; screening; study characteristics; success; young woman

DESCRIPTION (provided by applicant): Contrast-enhanced MRI has been proven to be a very sensitive modality for the early diagnosis of breast cancer in young women and/or in women with radiographically-dense breasts. The American Cancer Society recommends that high-risk women with lifetime risk greater than 20% should receive annual breast MRI screening. Depending on the practitioner and study characteristics, MRI may have a high false positive rate (with specificity reported as low as 81%), which can lead to many unnecessary procedures or even over-treatment. Positron emission mammography ("PEM"), the breast-specific high-resolution molecular imaging system originally invented by the PI of the submitted proposal, has been demonstrated to have a high negative predictive value. Integrating a PEM system into MRI for combined imaging is therefore likely to increase diagnostic accuracy. Furthermore, the recent commercialization of PET/CT and PET/MR clinical systems has led to wide acceptance in the oncology community for combined anatomic and molecular imaging. The goal of this application is therefore to design and construct a PEM system that could be used in conjunction with an MRI scanner. The developed PEM/MRI system in this project could be used in cancer detection, in personalizing care for breast cancer patients, and in the development of new drugs for prevention and therapy.

描述（由申请人提供）：事实证明，对比度增强的MRI是年轻女性和/或放射线密集乳房的乳腺癌早期诊断的一种非常敏感的方式。美国癌症协会建议，终生风险大于20％的高风险女性应接受年度乳房MRI筛查。根据从业人员和研究特征，MRI可能具有很高的假阳性率（据报道低至81％），这可能会导致许多不必要的程序甚至过度治疗。正电子发射乳房X线摄影（“ PEM”）是最初由提交建议的PI发明的乳房特异性高分辨率分子成像系统，已被证明具有很高的负预测值。因此，将PEM系统整合到MRI中进行组合成像可能会提高诊断准确性。此外，最近对PET/CT和PET/MR临床系统的商业化已导致肿瘤学界的全面解剖学和分子成像的广泛接受。因此，该应用的目的是设计和构建可以与MRI扫描仪结合使用的PEM系统。该项目中开发的PEM/MRI系统可用于癌症检测，对乳腺癌患者的个性化护理以及开发用于预防和治疗的新药。