International
国际的
基本信息
- 批准号:7685026
- 负责人:
- 金额:$ 30.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-06-15 至 2014-05-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS/HIV problemAchievementAcquired Immunodeficiency SyndromeAdvisory CommitteesAffectAfricaAfrica South of the SaharaApplications GrantsAreaAttentionBasic ScienceBiostatistics CoreChargeChinaClinicClinicalClinical ResearchClinical Trials NetworkCollaborationsCommunitiesCountryDNA SequenceDataData SetDatabasesDevelopmentDiagnostic ProcedureElementsEmergency SituationEpidemicEpidemiologic StudiesExplosionFacultyFellowshipFlow CytometryFundingGrowthHIVHealthHeartInfantInfectious Diseases ResearchInstitutionInternationalJamaicaKnowledgeLaboratoriesLeadershipLifeLife ExpectancyMeasuresMentorshipMissionOutcomePathogenesisPatientsPeer ReviewPeruPhysiciansPlayPregnant WomenPreventionProcessProductivityProtocols documentationPublicationsReapplicationRecruitment ActivityResearchResearch InfrastructureResearch PersonnelResearch TrainingResistanceResourcesRetrievalRoleRwandaSamplingScientistServicesShippingShipsSideSiteSpecimenStrategic PlanningSystemTestingTherapeuticTimeTrainingUNICEFVertical Disease TransmissionViral Load resultWorkZambiabaseclinical carecombatdata managementimprovedinterestinvestigator trainingmemberpandemic diseasepreventprogramsrepositoryresearch studysample collectionskillssuccesstranslational studytreatment programvirology
项目摘要
The International Core (1C) has been a major element of the UAB CFAR since 1997. With the change in CFAR and 1C
leadership in this last project period, the 1C has sharply focused on Zambia and the remarkable achievements
occurring there, principally through a direct partnership with the Center for Infectious Diseases Research in Zambia
(CIDRZ). The CFAR helped establish CIDRZ in the late 1990s with a mission to provide infrastructure support for HIV
related research and treatment programs in Zambia. Over the last funding period, the CFAR has enabled CIDRZ to
create laboratory capacity in high-through put clinical laboratory testing, high quality flow cytometry for accurate CD4
determinations, viral load testing, TB culture and rapid diagnostic techniques, and HIV resistance capabilities. The
most important role CFAR has played is in creating the clinical care protocols and infrastructure to support the rollout
of the PEPFAR program via CIDRZ and the Zambian Ministry of Health. Using this remarkable system, the PEPFAR
program in Lusaka now operates in 46 community clinics and has evaluated over 165,000 HIV infected patients,
placing over 100,000 of them on ARV treatment. The CIDRZ team, since 1999, has evaluated over 500,000 pregnant
women for prevention of mother-to-child transmission and prevented tens of thousands of infants from becoming HIV
infected. The CFAR helped create the proper infrastructure to support DAIDS-sponsored Network clinical trials and a
specimen repository that is used to support the clinical-translational studies in Lusaka, helping to establish
bidirectional research and training opportunities between Zambian and UAB investigators. The Specific Aims of the
1C for this next project period are:
1) To develop further the CFAR/CIDRZ specimen repository in order to provide patient samples to investigators with
high-quality research ideas, with a focus on projects most relevant to Zambia;
2) To develop further the CFAR/CIDRZ data repository in order to provide analysis datasets and analytic support to
investigators with high-quality research ideas, paying special attention to junior investigators and Zambian
investigators;
3) To provide bidirectional training in clinical and basic science research for Birmingham-based CFAR Members and
Zambian Investigators;
4) To provide leadership and strategic planning for CIDRZ and other CFAR collaborators in Zambia through support
of the CIDRZ Scientific Advisory Committee.
The measures for success for the 1C will be the number of new programs initiated and supported, numbers of new
grant proposals submitted including Developmental Grant proposals, numbers of publications from ongoing projects,
the number of new Zambian investigators trained by the Core and their productivity, and the contributions by other
UAB groups or centers to the overall 1C effort.
自 1997 年以来,国际核心 (1C) 一直是 UAB CFAR 的主要组成部分。随着 CFAR 和 1C 的变化
在最后一个项目期间,1C 的领导重点关注赞比亚并取得了显著成就
在那里发生,主要是通过与赞比亚传染病研究中心的直接合作伙伴关系
(CIDRZ)。 CFAR 在 20 世纪 90 年代末帮助建立了 CIDRZ,其使命是为艾滋病毒提供基础设施支持
赞比亚的相关研究和治疗项目。在上一个资助期内,CFAR 使 CIDRZ 能够
建立高通量临床实验室检测、高质量流式细胞术的实验室能力,以实现准确的 CD4
测定、病毒载量检测、结核病培养和快速诊断技术以及艾滋病毒抵抗能力。这
CFAR 发挥的最重要作用是创建临床护理协议和基础设施以支持推广
通过 CIDRZ 和赞比亚卫生部参与 PEPFAR 计划。利用这个卓越的系统,PEPFAR
卢萨卡的项目现已在 46 个社区诊所开展,并已评估了超过 165,000 名艾滋病毒感染者,
其中超过 100,000 人接受了抗逆转录病毒治疗。自 1999 年以来,CIDRZ 团队已评估了超过 500,000 名孕妇
妇女预防母婴传播,防止数万名婴儿感染艾滋病毒
已感染。 CFAR 帮助创建了适当的基础设施来支持 DAIDS 赞助的网络临床试验和
用于支持卢萨卡临床转化研究的样本库,帮助建立
赞比亚和 UAB 调查人员之间的双向研究和培训机会。具体目标
下一个项目周期的 1C 是:
1) 进一步开发 CFAR/CIDRZ 样本库,以便为研究人员提供患者样本
高质量的研究想法,重点关注与赞比亚最相关的项目;
2)进一步开发CFAR/CIDRZ数据存储库,为数据分析提供分析数据和支持
具有高质量研究思路的研究者,特别关注初级研究者和赞比亚人
调查员;
3) 为伯明翰的CFAR会员提供临床和基础科学研究方面的双向培训
赞比亚调查人员;
4) 通过支持为 CIDRZ 和赞比亚的其他 CFAR 合作者提供领导和战略规划
CIDRZ 科学咨询委员会的成员。
1C 成功的衡量标准将是发起和支持的新计划的数量、新项目的数量
提交的拨款提案包括发展拨款提案、正在进行的项目的出版物数量、
核心培训的赞比亚新调查员的数量及其生产力,以及其他方面的贡献
UAB 负责整体 1C 工作的分组或中心。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JEFFREY Samuel Allen STRINGER其他文献
JEFFREY Samuel Allen STRINGER的其他文献
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{{ truncateString('JEFFREY Samuel Allen STRINGER', 18)}}的其他基金
A Randomized Trial of 17-Hydroxyprogesterone Caproate (17P) to Reduce Preterm Birth Among Women Receiving Antiretroviral Therapy in Pregnancy
17-羟基孕酮己酸酯 (17P) 减少妊娠期接受抗逆转录病毒治疗的妇女早产的随机试验
- 批准号:
9360140 - 财政年份:2016
- 资助金额:
$ 30.34万 - 项目类别:
A Randomized Trial of 17-Hydroxyprogesterone Caproate (17P) to Reduce Preterm Birth Among Women Receiving Antiretroviral Therapy in Pregnancy
17-羟基孕酮己酸酯 (17P) 减少妊娠期接受抗逆转录病毒治疗的妇女早产的随机试验
- 批准号:
9769543 - 财政年份:2016
- 资助金额:
$ 30.34万 - 项目类别:
A Randomized Trial of 17-Hydroxyprogesterone Caproate (17P) to Reduce Preterm Birth Among Women Receiving Antiretroviral Therapy in Pregnancy
17-羟基孕酮己酸酯 (17P) 减少妊娠期接受抗逆转录病毒治疗的妇女早产的随机试验
- 批准号:
9271471 - 财政年份:2016
- 资助金额:
$ 30.34万 - 项目类别:
Point-of-care virologic testing to improve outcomes of HIV-infected children
护理点病毒学检测可改善艾滋病毒感染儿童的预后
- 批准号:
8691716 - 财政年份:2012
- 资助金额:
$ 30.34万 - 项目类别:
Point-of-care virologic testing to improve outcomes of HIV-infected children
护理点病毒学检测可改善艾滋病毒感染儿童的预后
- 批准号:
8298814 - 财政年份:2012
- 资助金额:
$ 30.34万 - 项目类别:
Point-of-care virologic testing to improve outcomes of HIV-infected children
护理点病毒学检测可改善艾滋病毒感染儿童的预后
- 批准号:
8500183 - 财政年份:2012
- 资助金额:
$ 30.34万 - 项目类别:
Centre for Infectious Diseases Research in Zambia HIV/AIDS Clinical Trials Unit
赞比亚传染病研究中心艾滋病毒/艾滋病临床试验单位
- 批准号:
7995968 - 财政年份:2007
- 资助金额:
$ 30.34万 - 项目类别:
Centre for Infectious Diseases Research in Zambia HIV/AIDS Clinical Trials Unit
赞比亚传染病研究中心艾滋病毒/艾滋病临床试验单位
- 批准号:
8197844 - 财政年份:2007
- 资助金额:
$ 30.34万 - 项目类别:
Centre for Infectious Diseases Research in Zambia HIV/AIDS Clinical Trials Unit
赞比亚传染病研究中心艾滋病毒/艾滋病临床试验单位
- 批准号:
8451508 - 财政年份:2007
- 资助金额:
$ 30.34万 - 项目类别:
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