STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS

使用树枝状脂质扩展膜电荷密度的极限

• 批准号: 7956428
• 负责人: CYRUS R SAFINYA
• 金额: $ 1.29万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956428
• 关键词: Charge; Computer Retrieval of Information on Scientific Projects Database; Controlled Study; DNA delivery; Funding; Grant; Head; Institution; Lipids; Membrane; Microscopy; Molecular; Research; Research Personnel; Resources; Source; Stretching; Transfection; United States National Institutes of Health; density; design; vector

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Newly designed multivalent lipids ranging in head group charge from 4+ to 16+ have been synthesized and investigated as DNA delivery vectors. These dendritic lipids (DLs) allow a controlled study of the relationship between membrane charge density and transfection efficiency (TE).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 新设计的多价脂质的头基电荷范围为 4+ 至 16+，已被合成并作为 DNA 递送载体进行研究。这些树突状脂质 (DL) 允许对膜电荷密度和转染效率 (TE) 之间的关系进行受控研究。